Estudio de Factibilidad para Evaluar la Proporción de Cáncer Atribuible a Factores Modificables en el Perú y Latinoamérica

Cruz-Vargas, Jhony A. De La; Ramos, Willy; Chanduví, Willer; Espinoza-Rojas, Rubén; Guerrero, Nadia; Loayza-Castro, Joan A.; Carpio, Ronald; Alarico, Manuel Loayza

doi:10.25176/rfmh.v20i1.2657

Cited by 3 publications

(4 citation statements)

References 23 publications

(51 reference statements)

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“…Prioritizing optimal vaccination coverage against oncogenic infections such as HPV and HBV [ 39 , 40 ]. Simultaneously, implementing effective strategies to promote healthy lifestyles in the population, including reducing tobacco consumption, increasing physical activity, and fostering healthy dietary habits is essential [ 8 , 37 ]. On the other hand, evidence from various researches, such as the analysis of mortality trends related to gastric cancer, demonstrates that improving access to safe water can significantly reduce the burden of gastric cancer attributed to Helicobacter pylori [ 34 , 40 – 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Potentially modifiable risk factors significantly contribute to numerous cancers, and the current estimation of this proportion within a population, known as the PAF, constitutes a valuable tool for prioritizing cancer prevention and control programs and interventions [ 8 ] and, in turn, allows us to estimate the percentage of cases that could have been avoided if exposure to associated risk factors had been minimized compared to the reference level [ 9 ]. There has been PAF studies assessing modifiable cancer risk factors in various regions such as North America (United States and Canada) [ 10 , 11 ], Europe (England) [ 12 ], Asia (China, Japan) [ 13 , 14 ] and the Middle East [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

De La Cruz-Vargas,

Ramos,

Chanduví

et al. 2024

BMC Cancer

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Background Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and their associated diseases. The objective of this study was to estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, before the COVID-19 pandemic in the population of 15 years old and older. Methods An ecological study was conducted using the prevalence of exposure of the Peruvian population to modifiable risk factors for cancer, the relative risk associated with each factor, and the number of cancer cases and deaths in 2018 as inputs. We used the Parkin formula with a Montecarlo statistical simulation model to calculate the PAF and confidence intervals. The number of new cancer cases and deaths attributed to each risk factor was determined by multiplying the number of cases and deaths in each gender by the PAF of each risk factor. Findings In Peru, 38.5% of new cases (34.5% in men and 42% in women) and 43.4% of cancer-related deaths (43.4% in men and 43.4% in women) were attributable to modifiable risk factors. The number of cancers attributable was 25,308 (10,439 in men and 14,869 in women) and the number of deaths attributable to cancer was 14,839 (6,953 in men and 7,886 in women). The predominant modifiable risk factors contributing to the highest number of cases and deaths were HPV infection (4,563 cases, 2,409 deaths), current tobacco use (3,348 cases, 2,180 deaths), and helicobacter pylori infection (2,677 cases, 1,873 deaths). Among the risk factors, oncogenic infections constituted the group with the highest PAF (16.6% for cases, 19.2% for deaths) followed by other unhealthy lifestyle factors (14.2% for cases, 16.7% for deaths), tobacco (7.2% for cases, 7.2% for deaths) and ultraviolet radiation (0.5% for cases, 0.3% for deaths). Conclusions Prior to the COVID-19 pandemic, 38.5% of cancer cases and 43.4% of cancer-related deaths in Peru were linked to modifiable risk factors in the population of 15 years old and older. Most preventable cancer cases and deaths were related to oncogenic infections, primarily caused by HPV and helicobacter pylori, followed by tobacco and obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

De La Cruz-Vargas,

Ramos,

Chanduví

et al. 2024

BMC Cancer

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“…Our data supports the need to strengthen the national plan for integral attention of Peruvian cancer with cost effective interventions such as vaccination against oncogenic infections such as HPV and HBV (29,30) that, while they are being considered, it is necessary to increase its coverage in the population. It is also necessary to implement practical strategies for the promotion and implementation of a healthy lifestyle in the population, particularly in factors related to avoiding tobacco use, physical activity, and healthy eating (8,27) . On the other hand, we need to consider the possibility of an aggressive policy of access to drinking water to reduce the burden of stomach cancer attributable to Helicobacter pylori (31)(32)(33)(34) .…”

Section: Discussionmentioning

confidence: 99%

“…Many cancers are causally related to potentially modifiable risk factors and current estimates of this proportion in a population, meaning, the population attributable fraction (PAF) constitutes a valuable tool for prioritizing cancer prevention and control programs and interventions (8) . PAF studies based on assessing modifiable cancer risk factors are available in North America (United States and Canada) , Europe (England) (11) , Asia (China, Japan) (12,13) and the Middle East (14) with PAFs ranging from 23% to 45% for cancer cases and from 41% to 51% for cancer deaths.…”

Section: Introductionmentioning

confidence: 99%

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru prior to the COVID-19 pandemic

De La Cruz-Vargas,

Ramos,

Chanduví

et al. 2023

Preprint

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OBJECTIVE: To estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, prior to the COVID-19 pandemic. MATERIAL AND METHODS: An ecological study was carried out using the prevalence of exposure of the Peruvian population to modifiable risk factors for cancer, relative risk of each risk factor, and number of cancer cases and deaths in 2018 as inputs. We used the Parkin formula with a Montecarlo statistical simulation model to calculate the population attributable fraction (PAF) and confidence intervals. The number of new cancer cases and deaths attributable to each risk factor was calculated by multiplying the number of cases and deaths in each sex by the PAF of each risk factor. RESULTS: 38.4% of new cases (34.4% in men and 41.8% in women) and 43.2% of deaths by cancer in Peru (43.1% in men and 43.2% in women) were attributable to modifiable risk factors. The number of cancers attributable was 25,591 (10,616 in men and 14,975 in women) and the number of deaths attributable to cancer was 14,922 (6,996 in men and 7,926 in women). The modifiable risk factors that caused a greater number of cases and deaths were HPV infection (4563 cases, 2410 deaths), current tobacco use (3387 cases, 2198 deaths), and Helicobacter pylori infection (2686 cases, 1874 deaths). The oncogenic infections made up the group of risk factors that presented a greater PAF (16.6% for cases, 19.1% for deaths) followed by other unhealthy lifestyle factors (14.1% for cases, 16.5% for deaths), tobacco (7.2% for cases, 7.3% for deaths) and ultraviolet radiation (0.5% for cases, 0.3% for deaths). CONCLUSION: Prior to the COVID-19 pandemic, a proportion of 38.4% of cancer cases and 43.2% of cancer deaths in Peru during 2018 were attributable to modifiable risk factors. Most preventable cancer cases and deaths are linked to oncogenic infections, primarily caused by HPV and Helicobacter pylori.

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Calidad de vida en pacientes con cáncer atendidos en un hospital nacional de Lima

Castillo¹,

Orrillo²

2021

Cuidado y Salud Pública

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Objetivo: Determinar la calidad de vida en pacientes con cáncer atendidos en un Hospital Nacional de Lima. Materiales y métodos: El estudio fue de enfoque cuantitativo y de diseño descriptivo y transversal, la población estuvo conformada por 109 pacientes con cáncer atendidos en el Hospital Nacional. La técnica de recolección de datos fue la encuesta y el instrumento de recolección de datos fue el cuestionario de calidad de vida EORCT QLQ-C30, que está comprendido por 30 ítems agrupados en 3 dimensiones. Resultados: En cuanto a los datos sociodemográficos de los participantes encontramos que 56,9 (n=62) son de sexo femenino y 43,1% (n=47) de sexo masculino. En cuanto a la calidad de vida de los participantes el 51,4% (n=56) tienen un nivel bajo y 48,6% (n=53) tienen un nivel alto. En cuanto a sus dimensiones, en estado global de salud el 56% (n=61) tiene un nivel bajo y el 44% (n=48) un nivel alto, en cuanto al área de funcionamiento el 52,3% (n=57) tiene un nivel bajo y 47,7% (n=52) un nivel alto, finalmente en cuanto al área de síntomas el 49,5% (n=54) tiene un nivel bajo y el 50,5% (n=55) un nivel alto. Conclusiones: En cuanto a la calidad de vida predomino el nivel bajo, seguido del alto. En cuanto a sus dimensiones, en estado global de salud y área de funcionamiento predomino el nivel bajo; y en área de síntomas predomino el nivel alto.

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Estudio de Factibilidad para Evaluar la Proporción de Cáncer Atribuible a Factores Modificables en el Perú y Latinoamérica

Cited by 3 publications

References 23 publications

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru prior to the COVID-19 pandemic

Calidad de vida en pacientes con cáncer atendidos en un hospital nacional de Lima

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