Estrogens in the daily diet: In vitro analysis indicates that estrogenic activity is omnipresent in foodstuff and infant formula

Behr, Maximilian; Oehlmann, Jörg; Wagner, Martin

doi:10.1016/j.fct.2011.07.039

Cited by 41 publications

(23 citation statements)

References 65 publications

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“…Presently, a notable source of exogenous estrogen exposure to humans comes from dietary phytoestrogens [48], most commonly from soybean-derived foods rich in genistein and daidzein. Relatively high levels of these compounds are also found in soy-based infant formulas, consumed by an estimated 12% of infants in the United States (US) [49].…”

Section: Developmental Origins Of Adult Reproductive Dysfunction Amentioning

confidence: 99%

Environmental factors, epigenetics, and developmental origin of reproductive disorders

Cheong

Adgent

et al. 2017

Reproductive Toxicology

182

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Sex-specific differentiation, development, and function of the reproductive system are largely dependent on steroid hormones. For this reason, developmental exposure to estrogenic and anti-androgenic endocrine disrupting chemicals (EDCs) is associated with reproductive dysfunction in adulthood. Human data in support of “Developmental Origins of Health and Disease” (DOHaD) comes from multigenerational studies on offspring of diethylstilbestrol-exposed mothers/grandmothers. Animal data indicate that ovarian reserve, female cycling, adult uterine abnormalities, sperm quality, prostate disease, and mating behavior are susceptible to DOHaD effects induced by EDCs such as bisphenol A, genistein, diethylstilbestrol, p,p′-dichlorodiphenyl-dichloroethylene, phthalates, and polyaromatic hydrocarbons. Mechanisms underlying these EDC effects include direct mimicry of sex steroids or morphogens and interference with epigenomic sculpting during cell and tissue differentiation. Exposure to EDCs is associated with abnormal DNA methylation and other epigenetic modifications, as well as altered expression of genes important for development and function of reproductive tissues. Here we review the literature exploring the connections between developmental exposure to EDCs and adult reproductive dysfunction, and the mechanisms underlying these effects.

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Section: Developmental Origins Of Adult Reproductive Dysfunction Amentioning

confidence: 99%

Environmental factors, epigenetics, and developmental origin of reproductive disorders

Cheong

Adgent

et al. 2017

Reproductive Toxicology

182

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“…Biosolids had a minor effect on hormones content, whereas irrigation water, which contained significant amounts of hormones, had the most substantial effect for example on the EDCs content in lettuce (Shargil et al, 2015). In a separate study samples of food and milk infant formula were found to possess estrogenic activity, showing that estrogenic compounds were omnipresent in foodstuff and were not limited to soy-based food (Behr et al, 2011). Xenoestrogenic compounds may also be found among food preservatives.…”

Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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“…daidzein, Genistein, kaempferol, Luteolin, naringenin, resveratrol and quercetin). They are common components of food supplements, including baby milk, follow-ons, and soy formula [157][158][159]. They are generally regarded as potentially beneficial in a number of conditions including cancer, type 2 diabetes, obesity, coronary heart disease, metabolic syndrome, and neurodegenerative diseases.…”

Section: Persistent Organic Pollutants (Pop) and Polycyclic Aromatic mentioning

confidence: 99%

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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Estrogens in the daily diet: In vitro analysis indicates that estrogenic activity is omnipresent in foodstuff and infant formula

Cited by 41 publications

References 65 publications

Environmental factors, epigenetics, and developmental origin of reproductive disorders

Environmental factors, epigenetics, and developmental origin of reproductive disorders

Risks and benefits related to alimentary exposure to xenoestrogens

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

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