Estrogenic mediation of serotonergic and neurotrophic systems: Implications for female mood disorders

Borrow, Amanda P.; Cameron, Nicole M.

doi:10.1016/j.pnpbp.2014.05.009

Cited by 98 publications

(70 citation statements)

References 209 publications

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“…As is shown in animal models, estrogens in the brain may have antipsychotic effects by inhibiting the actions of dopamine (Häfner et al, 1991) and increasing the expression of serotonin (Fink et al, 1998). In addition, many neuroprotective effects of estrogens are observed, including attenuation of neuroinflammation and neurodegeneration (Chakrabarti et al, 2014), protection against cerebral ischemia (Schreihofer and Ma, 2013), increasing levels of brain derived neurotrophic factors (BDNF) (Borrow and Cameron, 2014), and reducing oxidative stress and glutamatergic cell death (Garcia-Segura et al, 2001). The efficacy of testosterone in male patients on negative symptoms is promising as these symptoms are notoriously difficult to treat.…”

Section: Discussionmentioning

confidence: 99%

Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Heringa

Begemann

Goverde

et al. 2015

Schizophrenia Research

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Section: Discussionmentioning

confidence: 99%

Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Heringa

Begemann

Goverde

et al. 2015

Schizophrenia Research

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“…Combined with the current data, these studies suggest that caffeine influences feelings of pleasure and arousal in a sex-dependent manner. Indeed, oestrogen has been shown to both affect caffeine metabolism (Lane et al, 1992) and play a role in the increased prevalence of mood disorders in females compared with males (Borrow & Cameron, 2014). Further work is needed to understand the complexities and mechanisms involved.…”

Section: Discussionmentioning

confidence: 99%

Caffeine ingestion enhances perceptual responses during intermittent exercise in female team-game players

Ali

O’Donnell

Hurst

et al. 2015

Journal of Sports Sciences

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We examined the influence of caffeine supplementation on cognitive performance and perceptual responses in female team-game players taking low-dose monophasic oral contraceptives of the same hormonal composition. Ten females (24 ± 4 years; 59.7 ± 3.5 kg body mass; 2-6 training sessions per week) took part in a randomised, double-blind, placebo-controlled crossover-design trial. A 90-min intermittent treadmill-running protocol was completed 60 min following ingestion of a capsule containing either 6 mg • kg(-1) anhydrous caffeine or artificial sweetener (placebo). Perceptual responses (ratings of perceived exertion (RPE), feeling scale (FS), felt arousal scale (FAS)), mood (profile of mood states (POMS)) and cognitive performance (Stroop test, choice reaction time (CRT)) were completed before, during and after the exercise protocol, as well as after ~12 h post exercise. Caffeine ingestion significantly enhanced the ratings of pleasure (P = 0.008) and arousal (P = 0.002) during the exercise protocol, as well as increased vigour (POMS; P = 0.007), while there was a tendency for reduced fatigue (POMS; P = 0.068). Caffeine ingestion showed a tendency to decrease RPE (P = 0.068) and improve reaction times in the Stroop (P = 0.072) and CRT (P = 0.087) tests. Caffeine supplementation showed a positive effect on perceptual parameters by increasing vigour and a tendency to decrease fatigue during intermittent running activity in female games players taking low-dose monophasic oral contraceptive steroids (OCS).

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“…16 Likewise, with few exceptions, the prevalence, incidence, and morbidity risk of depressive disorders are higher in women than in men, beginning at mid-puberty and persisting through adult life. 17 There appeared to be a higher frequency of cardiovascular risk factors in patients who underwent ECT. It remains to be seen whether vascular depression, an entity prominent in patients with cardiovascular diseases, may lead to a greater need of ECT.…”

Section: Discussionmentioning

confidence: 97%

Indicators for Electroconvulsive Therapy among Patients Hospitalized for Depression

Suri¹,

Adil²,

Qureshi³

et al. 2015

Psychiatric Annals

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This article compares various characteristics, including demographics, comorbid conditions, hospital status, and outcomes, in patients with major depression who received electroconvulsive therapy (ECT) versus those who did not. It seeks to determine if dyslipidemia is an indicator for ECT among patients hospitalized for depression. Data from all patients admitted to US hospitals between 2009 and 2010 with a primary discharge diagnosis of depression were included. We compared patients with depression who received ECT with those who did not. A logistic regression analysis was used to identify the association between patient and hospital characteristics and odds of receiving ECT. All variables that were significant in the univariate analysis were added as predictor variables to the stepwise logistic regression model. A total of 925,060 patients with depression were included. Of these, 20,251 (2.2%) underwent ECT. In the stepwise logistic regression, female gender (odds ratio [OR] 1.3, 95% confidence interval [CI] 1.2-1.5), white ethnicity (OR 1.8, 95% CI 1.2-2.5), and dyslipidemia (OR 1.3, 95% CI 1.0-1.6) were associated with receiving ECT among the patients with major depression. Large-sized hospitals (OR 1.9, 95% CI 1.2-2.9) and teaching hospitals (OR 3.2, 95% CI 2.1-4.8) were more likely to use ECT.

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Estrogenic mediation of serotonergic and neurotrophic systems: Implications for female mood disorders

Cited by 98 publications

References 209 publications

Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Caffeine ingestion enhances perceptual responses during intermittent exercise in female team-game players

Indicators for Electroconvulsive Therapy among Patients Hospitalized for Depression

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