Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Heringa, Sophie M.; Begemann, Marieke J H; Goverde, Angelique J.; Sommer, Iris E.

doi:10.1016/j.schres.2015.04.002

Cited by 73 publications

(60 citation statements)

References 98 publications

(164 reference statements)

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“…It was affirmed that menopause as a life event has no effect on quality of life but the presence and intensity of climacteric symptoms may have a negative impact on all the aspects of quality of life (Kim et al, 2013). Despite a submission that physical, social and psychological changes that occur during the menopausal stage of women have negative effects on their QoL (Teoman, Özcan, & Acar, 2004), there has been presumption that ethnic diversity may be responsible for differences in quality of life of individuals in different geographical locations (Heringa et al, 2015). Hence, one may tend to conclude that the insignificant difference in quality of life of participants in this study is a result of the inability of the UQoL to consider the ethnic diversity of postmenopausal women in Kumasi.…”

Section: Resultsmentioning

confidence: 99%

Lipid profile, cardiorespiratory function and quality of life of postmenopausal women improves with aerobic exercise

Akwa¹,

Moses²,

Emikpe³

et al. 2017

jhse

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Objective: Menopause is characterized by physiological changes with increased risk of obesity, dyslipidemia and decreased quality of life (QoL). Despite the plethora of reports on the alleviating effect of exercise on climacteric symptoms, there is little documentation of this lifestyle intervention among Ghanaian menopausal women. This study examined the effect of aerobic exercise on lipid profile, cardiorespiratory function and QoL among menopausal women. Methods: Eighteen sedentary postmenopausal women between 45 to 75 years were randomly assigned to experimental (EG, n=8) and control (CG, n=10) groups. The EG received moderate intensity aerobic exercise training for eight weeks, three times a week while the CG observed normal daily activities. Blood pressure, resting heart rate, BMI, and lipid profile were measured and QoL assessed using the Utian QoL questionnaire at weeks 0 and 9. Results: After 8 weeks, the EG demonstrated significant decrease in cardiovascular risk ratio by 6.5L% and a non-significant decrease in LDL by 11.9L%. The CG showed significant increase in systolic BP by 3.2%L and a non-significant increase in LDL and cardiovascular risk by 14.9L% and 9.4L% respectively. QoL significantly improved in the EG group compared to CG after the 8 weeks. Conclusion: The health and QoL of participants in EG was significantly better than

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Section: Resultsmentioning

confidence: 99%

Lipid profile, cardiorespiratory function and quality of life of postmenopausal women improves with aerobic exercise

Akwa¹,

Moses²,

Emikpe³

et al. 2017

jhse

View full text Add to dashboard Cite

show abstract

“…In addition, varying concentrations of endogenous sex hormones in male vs. female, and premenopausal vs. postmenopausal women may also influence the presence and severity of SCZ symptoms. For instance, in premenopausal SCZ women, estrogens are associated with improved positive and negative symptoms (Heringa et al, 2015), whereas testosterone is associated with improved negative symptoms in SCZ males (Heringa et al, 2015). Additional considerations in women include differential responsiveness of the OT system depending on the stage of a woman's menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

Effects of intranasal oxytocin on neural processing within a socially relevant neural circuit

Singh

Nunag

Muldoon

et al. 2016

European Neuropsychopharmacology

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Dysregulation of the Mirror Neuron System (MNS) in schizophrenia (SCZ) may underlie the cognitive and behavioral manifestations of social dysfunction associated with that disorder. In healthy subjects intranasal (IN) oxytocin (OT) improves neural processing in the MNS and is associated with improved social cognition. OT's brain effects can be measured through its modulation of the MNS by suppressing EEG mu-band electrical activity (8-13 Hz) in response to motion perception. Although IN OT's effects on social cognition have been tested in SCZ, OT's impact on the MNS has not been evaluated to date. Therefore, we designed a study to investigate the effects of two different OT doses on biological motion-induced mu suppression in SCZ and healthy subjects. EEG recordings were taken after each subject received a single IN administration of placebo, OT-24IU and OT-48IU in randomized order in a double-blind crossover design. The results provide support for OT's regulation of the MNS in both healthy and SCZ subjects, with the optimal dose dependent on diagnostic group and sex of subject. A statistically significant response was seen in SCZ males only, indicating a heightened sensitivity to those effects, although sex hormone related effects cannot be ruled out. In general, OT appears to have positive effects on neural circuitry that supports social cognition and socially adaptive behaviors. Published by Elsevier B.V. E-mail address: fsingh@ucsd.edu (F. Singh). European Neuropsychopharmacology (]]]]) ], ]]]-]]]Please cite this article as: Singh, F., et al., Effects of intranasal oxytocin on neural processing within a socially relevant neural circuit. European Neuropsychopharmacology (2015), http://dx

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“…Further, both clinical study and animal models of SZ show that estrogen treatments, including HRP or SERM, can reduce both positive and negative symptoms of SZ in females (Arad and Weiner, 2010, 2012; Begemann et al, 2012; Bergemann et al, 2007). Yet estrogen treatments for menopausal women appear to be effective only in reducing negative symptoms (Heringa et al, 2015). Since most animal models of SZ use adult males (for comprehensive review see Jones et al, 2011), few studies have identified biological and pharmacological mechanisms underlying estrogens’ effects on reducing SZ-like symptoms in aged females.…”

Section: Szmentioning

confidence: 99%

Sex-dependent mental illnesses and mitochondria

Shimamoto

Rappeneau

2017

Schizophrenia Research

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The prevalence of some mental illnesses, including major depression, anxiety-, trauma-, and stress-related disorders, some substance use disorders, and later onset of schizophrenia, is higher in women than men. While the higher prevalence in women could simply be explained by socioeconomic determinants, such as income, social status, or cultural background, extensive studies show sex differences in biological, pharmacokinetic, and pharmacological factors contribute to females’ vulnerability to these mental illnesses. In this review, we focus on estrogens, chronic stress, and neurotoxicity from behavioral, pharmacological, biological, and molecular perspectives to delineate the sex differences in these mental illnesses. Particularly, we investigate a possible role of mitochondrial function, including biosynthesis, bioenergetics, and signaling, on mediating the sex differences in psychiatric disorders.

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Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review

Cited by 73 publications

References 98 publications

Lipid profile, cardiorespiratory function and quality of life of postmenopausal women improves with aerobic exercise

Lipid profile, cardiorespiratory function and quality of life of postmenopausal women improves with aerobic exercise

Effects of intranasal oxytocin on neural processing within a socially relevant neural circuit

Sex-dependent mental illnesses and mitochondria

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