Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae)

Oliveira, Ana Paula Siqueira de; Sousa, Juliana Ferreira de; Silva, Marcelo Aparecido da; Hilário, Felipe; Resende, Flávia Aparecida; Camargo, Margarete; Vilegas, Wagner; Santos, Lourdes Campaner dos; Varanda, Eliana Aparecida

doi:10.1016/j.steroids.2013.07.002

Cited by 19 publications

(10 citation statements)

References 56 publications

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“…Selective estrogen receptor modulators (SERMs) have been developed to preserve the benefits of traditional hormone therapy while avoiding unwanted side effects. Phytoestrogens may be added to the list of SERMs, given their agonist/ antagonist properties at estrogen sensitive tissues (Oliveira et al, 2013). However, the obtained results in this study showed the presence of compounds capable of interacting with the ER, as observed in RYA and induce damage in the genetic material by the Ames test.…”

Section: Discussionmentioning

confidence: 65%

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

Resende

Nogueira

Espanha

et al. 2017

Regulatory Toxicology and Pharmacology

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Arrabidaea brachypoda (DC.) Bureau is a shrub native Cerrado, known as "cipó-una", "tintureiro" or "cervejinha do campo" and popularly used in Southeastern and Northeastern Brazil to treatment of kidney stones and painful joints (arthritis). Nevertheless, scientific information regarding this species is scarce, and there are no reports related to its possible estrogenic and mutagenic effects. Thus, the principal objective of this study was to assess the mutagenic and estrogenic activities of the hydroalcoholic extracts of the leaves, stalks, roots, their respective fractions and isolated compounds of A. brachypoda. The mutagenic activity was evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, in the absence (-S9) and presence (+S9) of metabolic activation system. In the RYA was used Saccharomyces cerevisiae engineered strain BY4741 (MATaura3Δ0 leu2Δ0 his3Δ1 met15Δ0) which reproduce the natural pathway of genetic control by estrogens in vertebrate cells; it has the advantage of its simplicity and a high throughput. All extracts and aqueous fraction of leaves A. brachypoda were mutagenic. The crude extract is more active than the fraction, suggesting a synergic effect. Only hydroalcoholic extracts of leaves and roots of A. brachypoda showed significant estrogenic activity, with ERα-dependent transcriptional activation activity. The obtained results in this study showed the presence of compounds capable of interacting with the estrogen receptor and to induce damage in the genetic material. Thus, we demonstrated the risk which the population is subjected due to indiscriminate use of extracts without detailed study.

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Section: Discussionmentioning

confidence: 65%

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

Resende

Nogueira

Espanha

et al. 2017

Regulatory Toxicology and Pharmacology

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“…The antimutagenic potential of xanthones and flavones of Syngonanthus ( Eriocaulaceae ) was stated with recombinant yeast assay (RYA) and the Ames test (de Oliveira et al 2013). This beneficial activity may be attributed to different mechanisms, such as the rapid elimination of mutagens from bacteria; the interaction between antimutagens and the reactive intermediates of mutagens; and the influence on microsomal enzymes.…”

Section: Antimutagens With Multiple Mechanisms Of Actionmentioning

confidence: 99%

Antimutagenic compounds and their possible mechanisms of action

et al. 2014

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Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.

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“…As postmenopausal hormone replacement has become an ever more complex issue, women have sought non estrogen alternatives to treat their menopausal symptoms and improve their overall health. Selective Estrogen Receptor Modulators (SERMs) have been developed to preserve the benefits of traditional hormone therapy while avoiding unwanted side effects (De Oliveira et al, 2013). SERMs are ER ligands that in some tissues act like estrogens, but block estrogen action in others through competitive inhibition of estrogen binding to Ers (Pinkerton and Thomas, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The ideal SERM would treat such symptoms as hot flashes, vaginal dryness and mood changes while protecting women from osteoporosis and heart disease. These benefits would be met without substantially increasing the risk of breast or endometrial cancer (De Oliveira et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Purnamasari

Bahtiar²

2018

OnLine Journal of Biological Sciences

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Menopause is a physiologic condition, in which women no longer experience menstruation. Decreased estrogen during and after menopause causes structural, physiological and biochemical changes that alter the health of women in general, both in organs and non-reproductive organs. Dayak onion contains eleuterinol, an naphtoqunone derivative that can be as SERM. Therefore, we evaluated the effects of dayak onions on lipid profiles and uterine wall. This study used female white rats of Sprague-Dawley. All groups, except the sham group, is ovariectomized to obtain the conditions of hypoestrogen. Rats were divided into 6 groups. SHAM (CMC Na 0,5%), OVX (CMC Na 0,5%), TAM (tamoxifen), DOE dose 1 (dayak onion extract 8 mg/200), DOE dose 2 (dayak onion extract 12 mg/200 g) and DOE dose 3 (dayak onion extract 18 mg/200 g). Mouse model of ovariectomy given 3 doses of extract, from giving each extract it was seen that the weight of uterine DOE dose 1, DOE dose 2 and DOE dose 3 respectively 55,24, 53,38 and 61,85 mg had lower uterine weight when compared with Positive control given tamoxifen 72.2 mg. The effects of onion on uterine weight reduction are greater than that of tamoxifen on the animal model menopause.

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Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae)

Cited by 19 publications

References 56 publications

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

Antimutagenic compounds and their possible mechanisms of action

Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

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