Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA)

Fujimoto, Nariaki; Kohta, Ryuki; Kawa, Shigeyuki; Honda, Hiroaki

doi:10.1016/j.lfs.2003.08.012

Cited by 32 publications

(28 citation statements)

References 24 publications

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“…It has been used as an antioxidant to preserve oils and foods, and is a well-known anticancer agent [6]. NDGA has been studied for its inhibition of the conversion of some ferric-centered enzymes to their inactive ferrous form, e.g., soybean lipoxygenase [7,8].…”

Section: Ise Membermentioning

confidence: 99%

Electrocatalytic properties of NDGA and NDGA/FAD hybrid film modified electrodes for NADH/NAD+ redox reaction

Chen

Liu

2006

Electrochimica Acta

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Section: Ise Membermentioning

confidence: 99%

Electrocatalytic properties of NDGA and NDGA/FAD hybrid film modified electrodes for NADH/NAD+ redox reaction

Chen

Liu

2006

Electrochimica Acta

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“…It has also been shown that nordihydroguaiaretic acid, a lignan, has estrogenic activity (Fujimoto et al, 2004). Until now, no evidence has been reported of a correlation between ER and eNOS phosphorylation induced by nectandrin B.…”

Section: Involvement Of the Er␣-dependent Pi3k/akt Pathway In Phosphomentioning

confidence: 99%

Nectandrin B Activates Endothelial Nitric-Oxide Synthase Phosphorylation in Endothelial Cells: Role of the AMP-Activated Protein Kinase/Estrogen Receptor α/Phosphatidylinositol 3-kinase/Akt Pathway

Hien

Oh²,

Nguyen³

et al. 2011

Mol Pharmacol

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We revealed previously that nectandrin B isolated from Myristica fragrans (nutmeg, Myristicaceae) functions as a potent AMP-activated protein kinase (AMPK) activator and showed its antiobesity effect. In this study, we investigated whether nectandrin B affects phosphorylation of endothelial nitric-oxide synthase (eNOS) in human endothelial cells. Nectandrin B increased the phosphorylation of eNOS and nitric oxide (NO) production in a concentration-dependent manner and maximal effect was found at 10 g/ml. Nectandrin B activates AMPK, presumably via Ca 2ϩ /calmodulin kinase II activation and nectandrin B-stimulated eNOS phosphorylation was reversed by AMPK inhibition. Both the enzyme activity of phosphatidylinositol 3-kinase (PI3K) and the estrogen receptor (ER)-dependent reporter gene transcription were enhanced by nectandrin B. ER␣ inhibition by specific antagonist or small interfering siRNA (siRNA) suppressed nectandrin B-mediated eNOS phosphorylation. Moreover, AMPK inhibition significantly reversed the activation of ER-dependent transcription and PI3K activation in response to nectandrin B. Nectandrin B evoked endothelium-dependent relaxation in rat aortic rings, and this was blocked by inhibition of AMPK, ER, or PI3K. These results suggest that potent AMPK activator nectandrin B enhances NO production via eNOS phosphorylation in endothelial cells and ER␣-dependent PI3K activity is required.

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“…1) [1]. NDGA possesses a number of interesting biological properties which are of potential use to humans such as enzyme inhibition [2], antimicrobial properties [3], protection from neurotoxicity and bladder toxicity [4,5], stimulation of the corpus luteum for the secretion of progesterone [6], potential vaso-and bronchodilation [7], and anti-apoptotic [8], estrogenic [9], antimutagenic [10] and anti-cancer [11] properties. NDGA has also been reported to possess both genotoxic [12] and anti-genotoxic potential [13] in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

et al. 2007

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Nordihydroguaiaretic acid (NDGA), a phenolic lignan, was tested for its antigenotoxic potential against chlormadinone acetate (CMA)-induced genotoxic damage in mice bone-marrow cells. Doses of about 22.50 mg/kg body weight of CMA were given along with 1, 5 and 10 mg/kg body weight of NDGA intraperitoneally. The treatment resulted in the reduction of sister chromatid exchanges and chromosomal aberrations induced by CMA, suggesting an antigenotoxic potential of NDGA. Earlier studies show that CMA generates reactive oxygen species, responsible for genotoxic damage. The free radical-scavenging property of NDGA is responsible for the reduction of genotoxic damage induced by CMA in mice bone-marrow cells.

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Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA)

Cited by 32 publications

References 24 publications

Electrocatalytic properties of NDGA and NDGA/FAD hybrid film modified electrodes for NADH/NAD+ redox reaction

Electrocatalytic properties of NDGA and NDGA/FAD hybrid film modified electrodes for NADH/NAD+ redox reaction

Nectandrin B Activates Endothelial Nitric-Oxide Synthase Phosphorylation in Endothelial Cells: Role of the AMP-Activated Protein Kinase/Estrogen Receptor α/Phosphatidylinositol 3-kinase/Akt Pathway

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

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