Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays

Morohoshi, Kaori; Yamamoto, Hiroshi; Kamata, Ryo; Shiraishi, Fujio; Koda, Tomoko; Morita, Masatoshi

doi:10.1016/j.tiv.2005.01.004

Cited by 185 publications

(118 citation statements)

References 30 publications

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“…Nevertheless, we suggest that phytoestrogens like equol may have a useful role as potential supplementary ingredients in topical sun-protective cosmetic products for humans particularly susceptible to nonmelanoma skin cancer. It is recognized that several UV-absorbing sunscreen ingredients have demonstrable estrogenic properties in cultured cells and rodents (44,45), but whether they disrupt normal endocrinology in humans is not yet clear (46,47). There may be a need for gender-specific photoprotective therapy in males, who can be anticipated to be deficient in this newly identified protective pathway.…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Widyarini

Domanski

Painter

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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The phytoestrogenic isoflavonoid equol is known to protect against solar-simulated UV radiation-induced inflammation, immunosuppression, and skin carcinogenesis. The mechanism may involve antioxidant actions, because equol not only is a radical scavenger but also enhances the induction of a relevant cutaneous antioxidant, metallothionein. However, this study in female hairless mice examined whether the estrogenicity of the isoflavonoid might be responsible. Protection by topically applied equol against photoimmune suppression was found to be strongly and dosedependently inhibited by the estrogen receptor (ER) antagonist ICI 182,780. Furthermore, ICI 182,780 alone was found to significantly exacerbate immunosuppression resulting from solar-simulated UV radiation irradiation, suggesting a natural role for the ER in photoimmune protection. In support of this role, topical application of the physiological ligand 17-␤-estradiol also provided dosedependent photoimmune protection, inhibitable by ICI 182,780, that was attributed largely to the inactivation of the downstream actions of cis-urocanic acid, an important endogenous immunosuppressive photoproduct. Thus, a hitherto unrecognized function of the ER as a normal photoprotective immune regulator in the skin was revealed. The relationship between equol and cutaneous metallothionein suggests an association of the ER with this inducible antioxidant in constraining the photoimmune-suppressed state and therefore in the prevention of the facilitation of photocarcinogenesis by this immunological defect. This role for the ER may underlie important gender-specific differences in UV-responsiveness that would reflect different needs for environmental photoprotection in males and females.cis-urocanic acid ͉ equol ͉ hairless mouse ͉ ICI 182,780 ͉ steroid hormone R ecent studies in mice with topically applied isoflavonoids derived from the red clover, Trifolium pratense, have shown that these phytochemicals may protect effectively against UV radiation-induced skin damage. Particular interest has centered on equol ([S]-4Ј7-dihydroxyisoflavane), an isoflavonoid metabolite produced from the dietary isoflavone daidzein by the gut microflora in mammals. Equol has been found to protect mice not only against UV radiation-induced cutaneous inflammation, observed as the sunburn reaction, but also against photoimmune suppression, which is evident as a defective contact hypersensitivity (CHS) reaction (1). Consistent with this observation, it was found that topical application to humans of an equol-related synthetic isoflavonoid, NV-07␣, also protected against the UV radiation-induced suppression of the elicited Mantoux reaction (2). In mice it was shown that the immunoprotective mechanism of topically applied equol involved inactivation of the downstream actions of cis-urocanic acid, a major UV-induced immunosuppressive photoproduct produced in the skin (1). Because chronic photoimmune suppression is a prerequisite for the promotion of UV radiation-initiated tumors (3), and because topica...

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Section: Discussionmentioning

confidence: 99%

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Widyarini

Domanski

Painter

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…13 This in vivo study suggests that UV-327 is likely to be linked to alterations in sex hormones, 14 although these compounds did not exhibit estrogenic activities in in vitro studies. 13 Because of their wide presence and potential toxic impact, BUVSs have been considered as emerging contaminants.…”

Section: Introductionmentioning

confidence: 84%

Field dissipation and plant uptake of benzotriazole ultraviolet stabilizers in biosolid-amended soils

Lai

Ying

et al. 2014

Environ. Sci.: Processes Impacts

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a Benzotriazole ultraviolet stabilizers (BUVSs) have been commonly used in industrial and household product formulations, and have been detected in biosolids from wastewater treatment plants. However, little is known about their occurrence and dissipation behavior in the soil environment associated with biosolid application. This study investigated the occurrence and dissipation of five typical BUVSs (UV-326, UV-327, UV-328, UV-329 and UV-P) in biosolid-amended soils, and the uptake of these biocides by plants.The field trial includes two treatment groups: old groups with biosolid application at rates of 5, 10, 20 and 40 t ha À1 every year within 5 years, and new groups with only one biosolid application. The resultsshowed that the five BUVSs could be detected in most biosolid-amended soils at a few to tens of ng g Environmental impactBenzotriazole ultraviolet stabilizers (BUVSs) are widely used as additives in paints, coatings, adhesives, polymeric surfaces, food packing lms and construction materials. They have been detected in biosolids from wastewater treatment plants. With application of biosolid to agricultural land, these chemicals may contaminate the agricultural soils and thus affecting the terrestrial ecosystem and human health. BUVSs (UV-326, UV-327, UV-328, UV-329 and UV-P) could be detected in the biosolid-amended soils at a few to tens of ng g À1 levels. This one year monitoring study demonstrated slow dissipation of the BUVSs in soil environments.

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“…Recently, some research started to estimate estrogenic properties of UV filters [129][130][131]. As shown in the literature, UV filters, even at low concentrations, may interfere with the endocrine system of mollusks.…”

Section: Uv Filtersmentioning

confidence: 99%

Research trends on emerging environment pollutants – a review

Rykowska

Wasiak

2015

Open Chemistry

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Concern for the natural environment increasingly devotes more attention to growing potential hazards resulting from the release of various substances. Currently, one of the main problems associated with environmental pollution is the derivation of organic compounds from wastewater. Substances derived from sewage leaks into the environment in the form of a multicomponent mixtures often enhances the toxic effects caused by these compounds. While analyzing the reports in the literature of the last two decades it can be seen that substantial efforts are devoted to the determination of selected trace contaminants present in wastewater. Among the most marked there are endocrine disrupting compounds, residues of pharmaceuticals and personal care products, plastics and sunscreens. Recently, a new group of compounds joined the aforementioned contaminants, namely drugs, whose legality and availability is increasing every year. Exposure to these type of compounds, named in the literature as emerging contaminants (ECs), involves, among others, such effects as hormonal imbalance, reduction of the survivability of aquatic organisms and reproductive problems.This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the natural environment in many countries all around the world.

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Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays

Cited by 185 publications

References 30 publications

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Field dissipation and plant uptake of benzotriazole ultraviolet stabilizers in biosolid-amended soils

Research trends on emerging environment pollutants – a review

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