Estrogenic activity and estrogen receptor β binding of the UV filter 3-benzylidene camphor

Schlumpf, Margret; Jarry, H.; Wuttke, W.; Ma, Risheng; Lichtensteiger, W.

doi:10.1016/j.tox.2004.02.015

Cited by 86 publications

(26 citation statements)

References 19 publications

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“…ERb may play a dual role: as a competitor of ERa at normal or low E 2 levels and as an alternative for ERa, inhibiting bone turnover and preventing bone loss in the presence of high E 2 levels (Sims et al 2002). The preferential affinity of daidzein and 4-MBC to ERb (Anderson & Garner 1997, Schlumpf et al 2004) and altered hormonal status in Ovx rats may influence the responses of skeleton. Furthermore, BW and body fat composition are mainly influenced by ERa-specific signaling (Ohlsson et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…filters studied (Schlumpf et al 2001). 4-MBC binds competitively to ERs with distinct preference for ERb (Schlumpf et al 2004) and prevents ovariectomy-induced bone loss in rat . Though 4-MBC has been reported to be an endocrine disruptor (Carou et al 2009), it is approved for use in the European Union for cosmetic products and non-food products.…”

Section: Introductionmentioning

confidence: 99%

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Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

Komrakova¹,

Sehmisch²,

Tezval³

et al. 2011

Journal of Endocrinology

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The study investigated the influence of 4-methylbenzylidene camphor (4-MBC), daidzein, and estradiol-17b-benzoate (E 2 ) on either intact or osteotomized cancellous bone in ovariectomized (Ovx) rats. Three-month old Ovx rats were fed with soy-free (SF) diet over 8 weeks; thereafter, bilateral transverse metaphyseal osteotomy of tibia was performed and rats were divided into groups: rats fed with SF diet and SF diet supplemented with 4-MBC (200 mg), daidzein (50 mg), or E 2 (0 . 4 mg) per kilogram body weight. After 5 or 10 weeks, computed tomographical, biomechanical, histological, and ashing analyses were performed in lumbar spine and tibia of 12 rats from each group. 4-MBC and E 2 improved bone parameters in lumbar spine and tibia, were not favorable for osteotomy healing, and decreased serum osteocalcin level. However, daidzein improved bone parameters to a lesser extent and facilitated osteotomy healing. For lumbar spine, the bone mineral density was 338G9, 346G5, 361G6, and 360G5 mg/cm 3 in SF, daidzein, 4-MBC, and E 2 , respectively, after 10 weeks. For tibia, the yield load was 98G5, 114G3, 90G2, and 52G4 N in SF, daidzein, 4-MBC, and E 2 , respectively, after 10 weeks. Serum daidzein was 54G6 ng/ml in daidzein group and equol was not detected. Alp and Igf1 genes were down-regulated in callus after daidzein and E 2 compared with 4-MBC (week 5). The response of bone tissue and serum markers of bone metabolism could be ordered: daidzein!4-MBC!E 2 . Treatments were more effective after 5 vs 10 weeks. In SF group, bone structure was impaired after 5 weeks and improved after 10 weeks probably due to adaptation mechanisms to osteoporosis. In conclusion, it is conceivable that 4-MBC may improve bone tissue in osteoporotic organisms; osteoporotic patients with fractures could benefit from daidzein treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

Komrakova¹,

Sehmisch²,

Tezval³

et al. 2011

Journal of Endocrinology

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“…4-MBC and 3-BC showed anti-estrogenic activity in fish, mammals and cell-based bioassays [22,44,76]. Exposure to 3-BC during the early development and postnatal life of rat, could lead to significant changes of the expression of ERs and estrogen target genes [77].…”

Section: Endocrine Disrupting Effects Of Typical Uv Filtersmentioning

confidence: 99%

Recent Advances on Endocrine Disrupting Effects of UV Filters

Wang

Pan

et al. 2016

IJERPH

125

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Ultraviolet (UV) filters are used widely in cosmetics, plastics, adhesives and other industrial products to protect human skin or products against direct exposure to deleterious UV radiation. With growing usage and mis-disposition of UV filters, they currently represent a new class of contaminants of emerging concern with increasingly reported adverse effects to humans and other organisms. Exposure to UV filters induce various endocrine disrupting effects, as revealed by increasing number of toxicological studies performed in recent years. It is necessary to compile a systematic review on the current research status on endocrine disrupting effects of UV filters toward different organisms. We therefore summarized the recent advances on the evaluation of the potential endocrine disruptors and the mechanism of toxicity for many kinds of UV filters such as benzophenones, camphor derivatives and cinnamate derivatives.

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“…1) is used as a chemical sun protective agent and in cosmetic products at a maximum use concentration of 2% in the European Union [1]. Estrogenic effect of 3-BC has previously been reported in vivo in a fish assay [2], in an uterotrophic assay in immature rats as well as in MCF-7 cell proliferation in vitro cell assay [3,4]. In vivo developmental toxicity in rats has also been demonstrated for 3-BC [3].…”

Section: Introductionmentioning

confidence: 99%

Distribution of the UV filter 3-benzylidene camphor in rat following topical application

Søeborg

Ganderup

Kristensen

et al. 2006

Journal of Chromatography B

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Estrogenic activity and estrogen receptor β binding of the UV filter 3-benzylidene camphor

Cited by 86 publications

References 19 publications

Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

Recent Advances on Endocrine Disrupting Effects of UV Filters

Distribution of the UV filter 3-benzylidene camphor in rat following topical application

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