Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents

Lim, Sun-Hye; Ha, Tae‐Youl; Ahn, Jiyun; Kim, Suna

doi:10.1016/j.phymed.2011.02.002

Cited by 86 publications

(41 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these compounds exhibit antioxidant [1], antiplatelet [2], estrogenic [3], immunomodulatory, and antitumor properties [4]. Antibacterial effects of several constituents on Staphylococcus aureus and S. epidermidis [5] have been reported.…”

Section: Open Accessmentioning

confidence: 99%

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

et al. 2015

View full text Add to dashboard Cite

Abstract:Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.

show abstract

Section: Open Accessmentioning

confidence: 99%

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Recent studies have demonstrated that active fractions of the PCL seeds possess antimicrobial (Yin et al, 2004), immunomodulatory (Latha et al, 2000), antioxidative (Guo et al, 2005), antitumor (Sun et al, 1998), bone-strengthening (Lim et al, 2009;Tsai et al, 2007) and estrogenic activities (Lim et al, 2011). There are also reports suggesting that PCL extracts or constituents may be effective in the prevention and treatment of dementia (Hsieh et al, 2000), Parkinson's disease (Zhao et al, 2009) and ischemic stroke (Kim, 2005).…”

Section: Introductionmentioning

confidence: 99%

Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways

Lee

Kim

Baik

et al. 2015

European Journal of Pharmacology

View full text Add to dashboard Cite

“…Recent studies demonstrated that psoralen and isopsoralen specifically showed estrogen-like activity [11, 12], osteoblastic proliferation accelerating activity [13, 14], anticancer activity [15], antibacterial activity [16], and so forth. However, to the best of authors' knowledge, no information was available about the tissue distribution character of the 2 compounds, and no investigation was reported comparing the fore-and-aft salt-process effect on scurfpea fruit.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting

Zhao

Yan

et al. 2016

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats' tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p < 0.05), ovary, and testes (p < 0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p < 0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.

show abstract

Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents

Cited by 86 publications

References 24 publications

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways

The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting

Contact Info

Product

Resources

About