Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: The Framingham study

Zhang, Yuqing; McAlindon, Timothy E.; Hannan, Marian T.; Chaisson, Christine E.; Klein, Ray; Wilson, Peter W.F.; Felson, David T.

doi:10.1002/1529-0131(199810)41:10<1867::aid-art20>3.3.co;2-n

Cited by 45 publications

(56 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zhang et al (26) investigated the relationship between estrogen use and radiologic progression of knee OA. No significant association was found between current use, past use, or never use of estrogen and progression of knee OA.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

133

View full text Add to dashboard Cite

Objective. To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods. We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis. Results. Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only highquality studies were included (n ‫؍‬ 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA. Conclusion. Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.

show abstract

Section: Resultsmentioning

confidence: 99%

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

133

View full text Add to dashboard Cite

show abstract

“…In a more clinically related study, Zhang et al demonstrated that postmenopausal women who take estrogen replacement therapy have a decreased chance of developing radiographic evidence of knee arthritis. In addition, the protective effect of estrogen replacement therapy was increased with the duration of the therapy [24]. It appears that estrogen may have a beneficial effect on cartilage; however, the exact mechanism of this protection has yet to be elucidated.…”

Section: Causes Of Knee Osteoarthritis In Womenmentioning

confidence: 99%

Knee osteoarthritis in women

Hame

Alexander

2013

Curr Rev Musculoskelet Med

163

111

View full text Add to dashboard Cite

Osteoarthritis is a disease that progresses over time and culminates in the destruction of articular cartilage and joints. Thus, with an increasing elderly population the treatment of knee osteoarthritis has become a major healthcare issue. It has been shown that women are more severely impacted by knee osteoarthritis. Differences in knee anatomy, kinematics, previous knee injury, and hormonal influences may play a role. Sex difference with respect to osteoarthritis presentation, treatment, and the allocation of resources also exists. In general, women present for treatment in more advanced stages of osteoarthritis and have more debilitating pain than their male counterparts. In addition, healthcare providers are more likely to recommend total joint arthroplasty for their male patients. Understanding how and why these gender differences occur is instrumental in formulating an inclusive strategy for combating osteoarthritis in the future.

show abstract

“…Estrogen replacement therapy (ERT) is effective in reducing or reversing postmenopausal bone loss [3] . In addition to its use for the treatment of postmenopausal symptoms, potential benefits of ERT include a reduction in the risk of osteoarthritis [4][5][6] and prevention of cardiovascular disease and dementia [7] . However, recent studies have shown that ERT is associated with a higher risk for breast, endometrial and ovarian cancer as well as cardiovascular disease and stroke [8,9] .…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

Xing

Wang

et al. 2011

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: To investigate the effect of genistein on bone homeostasis in mandibular subchondral bone of rats. Methods: Female SD rats were administered with genistein (10 and 50 mg/kg) or placebo by oral gavage for 6 weeks. Then the animals were sacrificed, and histomorphology and micro-structure of mandibular condyle were examined using HE staining and micro-CT analysis, respectively. The expression levels of alkaline phosphatase (ALP), osteocalcin (OC), osteoprotegerin (OPG), the receptor activator of nuclear factor κB ligand (RANKL) and estrogen receptors (ERs) in mandibular condyle were detected using real-time PCR. Cultured osteoblasts were prepared from rat mandibular condyle for in in vitro study. The cells were treated with genistein (10 -7 or 10 -4 mol/L) for 48 h. The expression of the bone homeostasis-associated factors and estrogen receptors (ERs) was detected using realtime PCR, and ER silencing was performed. Results: At both the low-and high-doses, genistein significantly increased the bone mineral density (BMD) and bone volume, and resulted in thicker subchondral trabecular bone in vivo. In both in vivo and in vitro study, the low-dose genistein significantly increased the expression of ALP, OC and OPG, but decreased the expression of RANKL and the RANKL/OPG ratio. The high-dose genistein decreased the expression of all these bone homeostasis-associated factors. Both the low and high doses of genistein significantly increased the expression of ERβ, while ERα expression was increased by the low dose genistein and decreased by the high dose genistein. ERβ silencing abrogated most of the effects of genistein treatment. Conclusion: In rat mandibular condylar subchondral bone, low-dose genistein increases bone formation and inhibit bone resorption, while excess genistein inhibits both bone formation and resorption. The effects of genistein were predominantly mediated through ERβ.

show abstract

Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: The Framingham study

Cited by 45 publications

References 3 publications

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Knee osteoarthritis in women

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

Contact Info

Product

Resources

About