Estrogen replacement improves skeletal muscle performance by increasing parvalbumin levels in ovariectomized rats

Bunratsami, Suchirat; Udomuksorn, Wandee; Kumarnsit, Ekkasit; Vongvatcharanon, Surapong; Vongvatcharanon, Uraporn

doi:10.1016/j.acthis.2014.12.003

Cited by 15 publications

(31 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in humans, it is difficult to tease apart aging from estrogen deprivation. Several animal studies have demonstrated adverse neuromuscular adaptations and functional outcomes following menopause within the hindlimb muscles in both young and old animals (Bunratsami, Udomuksorn, Kumarnsit, Vongvatcharanon, & Vongvatcharanon, 2015;Kadi et al, 2002;Moran, Warren, & Lowe, 2006;Velders & Diel, 2013). Nevertheless, the effects of menopause on the intrinsic laryngeal muscles are unexplored.…”

Section: Hormones Are Associated With Sarcopeniamentioning

confidence: 99%

A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

Lenell

Sandage

Johnson

2019

J Speech Lang Hear Res

View full text Add to dashboard Cite

Purpose The purpose of this tutorial is to summarize how sex hormones affect both laryngeal senescence and neuromuscular response to exercise, highlighting the importance of considering sex differences in developing treatment for the senescent voice. Conclusion Men and women's voices are sexually dimorphic throughout the life span, including during the laryngeal adaptations observed during senescence. Therefore, presbyphonia (age-related dysphonia) likely clinically manifests differently for men and women due to differences in how the male and the female larynx change in response to aging. Because sexual dimorphism is evident in both laryngeal aging and response to exercise, voice therapy programs aimed at treating the typical and disordered aged voice should consider sex differences in their design.

show abstract

Section: Hormones Are Associated With Sarcopeniamentioning

confidence: 99%

A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

Lenell

Sandage

Johnson

2019

J Speech Lang Hear Res

View full text Add to dashboard Cite

show abstract

“…These findings suggest a link between sarcopenia, skeletal muscle weakness, and estrogen loss. Although animal studies show that estradiol (E2) replacement improves skeletal muscle function in ovariectomized (OVX) mice and rats [5,6], clinical trials of estrogen-based hormone therapy in postmenopausal women have been contradictory with respect to physical function [7]. Moreover, given the possible increased risk of cardiovascular disease and breast cancer associated with estrogen-based hormone therapy [8,9], further investigations on the molecular mechanisms that underlie sarcopenia and skeletal muscle weakness in aged females after the loss of ovarian function are critical in order to develop more specific treatments with lower side effects.…”

Section: Introductionmentioning

confidence: 99%

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Wang

Alencar

Lin

et al. 2016

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

The molecular mechanisms of muscle weakness and sarcopenia in postmenopausal women are largely unknown. To determine the effect of a new estrogen receptor, GPR30, in the maintenance of exercise capacity and skeletal muscle function in females, the selective GPR30 agonist, G1 (100 μg/kg/day), or vehicle (V, soybean oil) was administered subcutaneously daily (n=7 per group) to ovariectomized (OVX) 27-month-old Fischer 344×Brown Norway (F344BN) female rats. Following 8 weeks of treatment, the exercise capacity (treadmill walk time to exhaustion) was reduced in OVX vs. sham rats (5.1±1.4 vs. 11.0±0.9 min, P<0.05), and chronic G1 restored exercise capacity (12.9±1.2 min; P<0.05 vs. OVX-V). Similarly, the peak twitch of electrically stimulated soleus muscles was decreased by 22% in OVX vs. sham rats (P<0.05), and G1 attenuated this decline (P<0.05). Western blot analysis showed that chronic G1 treatment attenuated OVX-associated decreases in heat shock protein (HSP) 90, HSP70, and HSP27 expressions. In vitro studies using the L6 myoblast cell line demonstrated that G1 increased mRNA levels of HSPs in cultured cells. Collectively, these data demonstrate that the activation of GPR30 mitigates the adverse effects of estrogen loss on exercise capacity and skeletal muscle contractile function in old F344BN rats. The protective effects of GPR30 might be through its upregulation of heat shock proteins in skeletal muscle.

show abstract

“…It should be noted that the dose of estradiol used in this study (10 lg kg À1 day À1 ) corresponds to a dose reported in the literature (Marie et al 1993;Li et al 2003;Syed et al 2010). Bunratsami et al (2015) demonstrated that OVX rats receiving ET also presented increased muscle mass, suggesting a potential therapeutic effect of estrogen on muscular function.…”

Section: Discussionmentioning

confidence: 51%

“…Bunratsami et al. () demonstrated that OVX rats receiving ET also presented increased muscle mass, suggesting a potential therapeutic effect of estrogen on muscular function.…”

Section: Discussionmentioning

confidence: 99%

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

et al. 2018

View full text Add to dashboard Cite

We investigated the effects of estrogen therapy (ET) associated with low‐intensity and high‐frequency mechanical vibration (MV) on bone tissue in osteopenic female mice. Fifty 3‐month‐old female Swiss mice were ovariectomized (OVX) or sham‐operated, and distributed after 4 months into the following groups, with 10 animals per group: Sham; Control, OVX + vehicle solution; MV, OVX + MV; ET, OVX + 17β‐estradiol; and MV + ET, OVX + MV and 17β‐estradiol. Both vehicle solution and 17β‐estradiol (10 μg kg−1 day−1) were injected subcutaneously 7 days per week, and vibration (0.6 g, 60 Hz) was delivered 30 min per day, 5 days per week. Bone mineral density (BMD) and body composition were evaluated by densitometry at baseline and after 60 days of treatment when the animals were euthanized, and their femurs underwent histomorphometric and histochemical analyses. The Control group showed increased weight and fat percentage, while the ET and MV + ET groups showed increased lean mass but decreased fat percentage. At the end of the treatment period, the BMD decreased in Control, remained constant in Sham and MV, and increased in ET and MV + ET. The MV + ET group showed the greatest bone volume compared with Sham (129%), Control (350%), MV (304%) and ET (14%). No differences occurred in cortical thickness. The Control group showed the highest content of mature collagen fibers, while the MV + ET group showed the highest content of immature collagen fibers. In conclusion, ET plus MV was effective in improving bone quality in osteopenic female mice, and this improvement is associated with specific changes in trabecular but not cortical bone.

show abstract

Estrogen replacement improves skeletal muscle performance by increasing parvalbumin levels in ovariectomized rats

Cited by 15 publications

References 24 publications

A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

Contact Info

Product

Resources

About