Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis

Feng, Chun; Xu, Zhisheng; Tang, Xiaojie; Cao, Haifei; Zhang, Guilong; Tan, Jian

doi:10.3390/molecules27133976

Cited by 8 publications

(6 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is due to the influence of the estrogen. The estrogen plays an important role in osteoclast replication so that mutations in the estrogen receptor can disrupt the balance of bone formation and absorption [7].…”

Section: Discussionmentioning

confidence: 99%

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Arnaya

Suyasa

Wiratnaya

et al. 2023

EJMED

View full text Add to dashboard Cite

Introduction: Malignant bone tumors have a global prevalence of 1% of the overall malignancy case, with a very low 5-year survival rate and high local recurrence. The limb-salvage surgery with bone recycling is widely developed in the management of malignant bone tumors. Hydrogen peroxide and liquid nitrogen are bone recycling mediator agents destroying the malignant tumor cells while preserving healthy bones as much as possible. The purpose of this study was to compare the effectiveness of hydrogen peroxide and liquid nitrogen with the number of tumor cell deaths using the Huvos score and BMP-2 expression in malignant bone tumors. Materials and Method: In vitro experimental research was performed on 30 core needle biopsy samples of bone malignant tumors divided into 2 groups of hydrogen peroxide and liquid nitrogen. The parameters measured are Huvos score and BMP-2 level. Results: Based on this study, the characteristics of malignant bone tumors were dominated by primary tumors (83.9%), in female patients (53.3%) with an average age of 30 years. Liquid nitrogen gave better results than hydrogen peroxide, marked by a lower Huvos score (average 12.13 vs. 18.87, p=0.033) and a higher BMP-2 (average 39.53 ± 26.59 vs. 63.87 ± 27.61, p=0.020). Conclusion: Liquid nitrogen is an effective bone recycling agent for the management of malignant bone tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Arnaya

Suyasa

Wiratnaya

et al. 2023

EJMED

View full text Add to dashboard Cite

show abstract

“…E2, as the major estrogen secreted by the female ovaries, can improve bone microstructure and BMD of the femur in PMOP rats, increase the content of bone formation indexes in serum and play a part in bone preservation [ 45 ]. As mentioned above, ERs play an important role in bone formation and bone resorption [ 34 , 46 ]. Many researchers have reported that ERs influence BMD and PMOP [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Secoisolariciresinol diglucoside regulates estrogen receptor expression to ameliorate OVX-induced osteoporosis

Chen,

Hong

et al. 2023

J Orthop Surg Res

View full text Add to dashboard Cite

Objective Secoisolariciresinol diglucoside (SDG) is a phytoestrogen that has been reported to improve postmenopausal osteoporosis (PMOP) caused by estrogen deficiency. In our work, we aimed to investigate the mechanism of SDG in regulating the expressions of ERs on PMOP model rats. Methods Ovariectomization (OVX) was used to establish PMOP model in rats. The experiment was allocated to Sham, OVX, SDG and raloxifene (RLX) groups. After 12-week treatment, micro-CT was used to detect the transverse section of bone. Hematoxylin and Eosin staining and Safranine O-Fast Green staining were supplied to detect the femur pathological morphology of rats. Estradiol (E2), interleukin-6 (IL-6), bone formation and bone catabolism indexes in serum were detected using ELISA. Alkaline phosphatase (ALP) staining was used to detect the osteogenic ability of chondrocytes. Immunohistochemistry and Western blot were applied to detect the protein expressions of estrogen receptors (ERs) in the femur of rats. Results Compared with the OVX group, micro-CT results showed SDG could lessen the injury of bone and improve femoral parameters, including bone mineral content (BMC) and bone mineral density (BMD). Pathological results showed SDG could reduce pathological injury of femur in OVX rats. Meanwhile, SDG decreased the level of IL-6 and regulated bone formation and bone catabolism indexes. Besides, SDG increased the level of E2 and conversed OVX-induced decreased the expression of ERα and ERβ. Conclusion The treatment elicited by SDG in OVX rats was due to the reduction of injury and inflammation and improvement of bone formation index, via regulating the expression of E2 and ERs.

show abstract

“…Recently, ESRRA has been a focus of research owing to its roles in the regulation of cell metabolism and function as well as its potential for the treatment of bone metabolism and bone homeostasis disorders [ 71 , 72 ]. The orphan nuclear estrogen receptor-related receptor alpha is expressed by osteoblasts and has clearly established functions in osteoprogenitor proliferation and differentiation [ 9 ].…”

Section: Postmenopausal Bone Marrow Adiposity and Fatty Acid Metaboli...mentioning

confidence: 99%

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Kim¹,

Ko²

2023

Pharmaceuticals

View full text Add to dashboard Cite

A variety of metabolic disorders are associated with a decrease in estradiol (E2) during natural or surgical menopause. Postmenopausal women are prone to excessive fat accumulation in skeletal muscle and adipose tissue due to the loss of E2 via abnormalities in lipid metabolism and serum lipid levels. In skeletal muscle and adipose tissue, genes related to energy metabolism and fatty acid oxidation, such as those encoding peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and estrogen-related receptor alpha (ERRα), are downregulated, leading to increased fat synthesis and lipid metabolite accumulation. The same genes regulate lipid metabolism abnormalities in the bone marrow. In this review, abnormalities in lipid metabolism caused by E2 deficiency were investigated, with a focus on genes able to simultaneously regulate not only skeletal muscle and adipose tissue but also bone metabolism (e.g., genes encoding PGC-1α and ERRα). In addition, the mechanisms through which mesenchymal stem cells lead to adipocyte differentiation in the bone marrow as well as metabolic processes related to bone marrow adiposity, bone loss, and osteoporosis were evaluated, focusing on the loss of E2 and lipid metabolic alterations. The work reviewed here suggests that genes underlying lipid metabolism and bone marrow adiposity are candidate therapeutic targets for bone loss and osteoporosis in postmenopausal women.

show abstract

Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis

Cited by 8 publications

References 68 publications

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Secoisolariciresinol diglucoside regulates estrogen receptor expression to ameliorate OVX-induced osteoporosis

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Contact Info

Product

Resources

About