Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats1

Qin, Xue; Xiao, Daliao; Zhang, Li

doi:10.1095/biolreprod.115.129619

Cited by 30 publications

(25 citation statements)

References 54 publications

(45 reference statements)

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“…In addition, Ang II receptor (AT1R and AT2R) signaling can be modulated by ER expression. For instance, decreased AT1R and increased AT2R expression have been observed in hearts of ovariectomized and/or estrogen-replaced mice to improve responses to ischemia and reperfusion injury (Xue et al 2015). Furthermore, estrogen signaling and its activity are strongly influenced by obesity-associated inflammatory markers (Zahid et al 2016).…”

Section: Estrogen Signalingmentioning

confidence: 99%

Mechanisms linking the renin-angiotensin system, obesity, and breast cancer

Rasha

Ramalingam

Gollahon

et al. 2019

Endocrine-Related Cancer

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Obesity is a complex disease and a global epidemic. It is a risk factor for other chronic diseases including breast cancer, especially in women after menopause. Diverse etiologies underlie the relationship between obesity and breast cancer. Adipose tissue is in part responsible for these interactions. In obesity, adipose tissue undergoes several metabolic dysregulations resulting in the secretion of many pro-inflammatory cytokines, growth factors, and hormones which in turn, can promote tumor microenvironment (TME) formation and cancer progression within the breast tissue. Angiotensin II (Ang II) is a well-known hypertensive hormone produced systemically and locally by the renin-angiotensin system (RAS). Activation of this system in obesity is a potential contributor to local and systemic inflammation in breast adipose tissue. Ang II actions are primarily mediated through binding to its two receptors, type 1 (AT1R) and type 2 (AT2R). RAS inhibitors include angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) which are currently prescribed as safe antihypertensive therapies. Recent studies have explored the potential use of ACE-I and ARBs in breast cancer patients as anti-tumor agents. Therefore, it is vital to understand the role of RAS in breast cancer and identify mechanisms of Ang II and RAS inhibitors in the TME and in obesity and breast cancer crosstalk. In this review, we performed a detailed analysis and discussed mechanisms of Ang II-AT1R interactions in breast cancer with emphasis on obesity-associated breast cancer. We further summarized recent in vitro, in vivo and human studies that used ACE-I/ARB interventions to improve breast cancer outcomes.

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Section: Estrogen Signalingmentioning

confidence: 99%

Mechanisms linking the renin-angiotensin system, obesity, and breast cancer

Rasha

Ramalingam

Gollahon

et al. 2019

Endocrine-Related Cancer

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“…Ovariectomy Yong Jin Kim and Kyung Eui Park contributed equally to this work. results in a decrease in AT receptors [8]. It increases AT production [9], and its increased secretion is associated with increased expression levels of AT receptor mRNA and protein [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Estradiol on the Paracrine Regulator Expression of In Vitro Maturated Murine Ovarian Follicles

Kim

Park

Kim

et al. 2017

Tissue Eng Regen Med

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The preservation of female germ cells is important in the individuals with ovarian dysfunction and failure. For this purpose, ovarian follicle in vitro maturation (OFIVM) is an important technology for the retrieval of mature oocytes. In the in vivo follicular development, paracrine factors such as angiotensin (AT) and anti-Müllerian hormone (AMH) play important roles. We attempted to add estrogen during the OFIVM and to assess their expression on the follicular cells. The ovaries and pre-antral follicles were collected from 13-day C57BL/6 mice and cultured in vitro with estradiol (E 2 ) treatment for up to two weeks. In the whole ovaries, the expression of AT II was decreased and the expression of AMH was similar between control and E 2 -treated ovaries after in vitro culture. Although there was no difference in the survival, ovulation, maturation and fertilization rates between control and E 2 -treated groups, the expression of AT II in the follicular cells was down-regulated after E 2 treatment at mRNA level, and AMH showed similar expression. In conclusion, adding E 2 in OFIVM may regulate paracrine factors and their receptors that are related to follicular development. Further investigations are necessary to elucidate the roles of various sex hormones in the regulation of AT and AMH expression during the OFIVM.

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“…We analyzed all neonates and stratified the data by sex based on increasing evidence that responses to neonatal encephalopathy are sex-specific. ( 15 – 20 )…”

Section: Introductionmentioning

confidence: 99%

Sex-specific associations between cerebrovascular blood pressure autoregulation and cardiopulmonary injury in neonatal encephalopathy and therapeutic hypothermia

Chavez‐Valdez¹,

O’Connor²,

Perin³

et al. 2017

Pediatr Res

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BackgroundCardiopulmonary injury is common in neonatal encephalopathy, but the link with cerebrovascular dysfunction is unknown. We hypothesized that cerebral autoregulation is associated with cardiopulmonary injury in neonates treated with therapeutic hypothermia (TH) for neonatal encephalopathy.MethodsThe cerebral hemoglobin volume index (HVx) from near-infrared spectroscopy was used to identify the mean arterial blood pressure (MAP) with optimal autoregulatory vasoreactivity (MAPOPT). We measured associations between MAP relative to MAPOPT and indicators of cardiopulmonary injury (duration of mechanical respiratory support and administration of inhaled nitric oxide (iNO), milrinone, or steroids).ResultsWe identified associations between cerebrovascular autoregulation and cardiopulmonary injury that were often sex-specific. Greater MAP deviation above MAPOPT was associated with shorter duration of intubation in boys but longer ventilatory support in girls. Greater MAP deviation below MAPOPT related to longer intensive care stay in boys. Milrinone was associated with greater MAP deviation below MAPOPT in girls.ConclusionMAP deviation from MAPOPT may relate to cardiopulmonary injury after neonatal encephalopathy, and sex may modulate this relationship. Whereas MAP above MAPOPT may protect the brain and lungs in boys, it may be related to cardiopulmonary injury in girls. Future studies are needed to characterize the role of sex in these associations.

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Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats1

Cited by 30 publications

References 54 publications

Mechanisms linking the renin-angiotensin system, obesity, and breast cancer

Mechanisms linking the renin-angiotensin system, obesity, and breast cancer

Effects of Estradiol on the Paracrine Regulator Expression of In Vitro Maturated Murine Ovarian Follicles

Sex-specific associations between cerebrovascular blood pressure autoregulation and cardiopulmonary injury in neonatal encephalopathy and therapeutic hypothermia

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