Estrogen receptor polymorphism, estrogen content and idiopathic scoliosis in human: A possible genetic linkage

Esposito, Teresa; Uccello, Rossella; Caliendo, R.; Martino, Gabriele; Carnevale, U.A. Gironi; Cuomo, Sergio; Ronca, Dante; Varriale, Bruno

doi:10.1016/j.jsbmb.2009.04.010

Cited by 40 publications

(44 citation statements)

References 39 publications

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“…Estrogen, due to its tight association with menarche, definitely has a role in interpreting the current study results. Lower levels of 17b-estradiol in blood have been revealed in Esposito's study in AIS population [6], which could interpret the late menarche generally detected in our study. Unfortunately, lower levels of sex steroid are not a constant finding [17].…”

Section: Discussionsupporting

confidence: 69%

“…Thus, girls with late onset of menarche may be susceptible to scoliosis progression, accounting for easier diagnosis and higher observed prevalence. Hormones contributing to the adjustment of menarche onset are potentially just modifying factors due to the fact that scoliosis prevalence shows a ratio of 1:1 between females and males in prepubertal periods, and the ratio is subsequently adjusted to 8.4/1 (female/male) during puberty, indicating a clear-cut sex-conditioned manifestation of AIS [6,16].…”

Section: Discussionmentioning

confidence: 99%

“…Age at menarche was also proposed to be related to prevalence of scoliosis. As Grivas et al reported, late age at menarche is parallel with higher prevalence of adolescent idiopathic scoliosis [5,6]. Thus, it is hypothesized that adjustment of menarche age may contribute to predisposition and curve progression potential of idiopathic scoliosis.…”

Section: Introductionmentioning

confidence: 97%

“…Thus, it is hypothesized that adjustment of menarche age may contribute to predisposition and curve progression potential of idiopathic scoliosis. In addition, potential difference of menarche age compared with normal control population may be correlated with hormonal disturbance involving estrogen, melatonin, and leptin [5][6][7][8][9][10], thus contributing to abnormal pubertal growth, which may be responsible for curve onset and progression of AIS. Such hypothesis, first and foremost, warrants menstrual status data supportive of abnormal menarche age with respect to general population.…”

Section: Introductionmentioning

confidence: 99%

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Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

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Age at menarche is closely related to scoliosis progression during adolescence. Current data concerning the timing of menarche between scoliotic and non-scoliotic girls in the literature are conflicting, with inconclusive results. The aim of this study was to investigate the distribution difference of age at menarche for adolescent idiopathic scoliosis (AIS) girls and normal control population and to subsequently elucidate the menarche age difference through literature reviewing. Moreover, menarche age of AIS girls with Cobb angle \40°, 40-60°, [60°were compared to estimate its association with curve severity. Menstrual status data were available for 6,376 healthy female adolescents and 2,196 AIS girls. We notice that less than 10% of healthy Chinese girls experienced onset of menses before 11.38 years, and approximately 90% of healthy Chinese girls were menstruating by 13.88 years, with a median age of 12.63 years. As for AIS girls, less than 10% started to menstruate before 11.27 years, and approximately 90% were menstruating by 14.38 years, with a median age of 12.83 years. Average menarche age in AIS (12.83 ± 1.22 years) was significantly later than that of normal control girls (12.63 ± 0.98 years) (p \ 0.001). Age at menarche for AIS affected girls was significantly greater than that of normal control girls at 75%, 90% of whom had attained menarche (p = 0.001, p \ 0.001). Proportion of girls starting to menstruate after 14 years was significantly higher in AIS population compared with normal controls (16.3 vs. 8.1%, p \ 0.001). In addition, AIS girls with Cobb angle [60°experienced onset of menses at an average age of 13.25 years, which was significantly later than AIS girls with Cobb angle \40°(12.81 years, p \ 0.05) and marginally significantly later than AIS girls with Cobb angle between 40 and 60°(12.86 years, p = 0.053). In conclusion, a tendency of delayed onset of menarche was observed in Chinese idiopathic scoliotic girls in this large sample study, especially for girls with Cobb angle [60°, which is supported by multiple previously established positive linkages on AIS etiology studies. Accordingly it is believed that late menarche may contribute importantly to abnormal pubertal growth and subsequently modulate curve behavior in AIS.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

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“…Furthermore, we hypothesized that the consequences of estrogen deficiency can be observed in both premenarcheal and postmenarcheal girls. Therefore, understanding the role of oestrogens seems vital for explaining the evolution of AIS associated with skeletal growth [24,29,[34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Kulis

Goździalska

Drąg

et al. 2015

International Orthopaedics (SICOT)

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Purpose In order to verify the potential association between the aetiopathogenesis of adolescent idiopathic scoliosis (AIS) and the process of sexual maturation, we determined the concentrations of oestrogens in pre-and postmenarcheal girls affected by this condition. AIS, occurring mostly in pubescent girls, is one of the most frequent forms of faulty posture. Therefore, it was assumed that the multifactorial pathomechanism of AIS involves significant deficiency of oestrogens. Methods The diagnosis of AIS was established on the basis of physical examination and analyses of radiograms. Concentrations of FSH, LH, oestrogens, progesterone, osteocalcin and RANKL were determined by ELISA. The activity of alkaline phosphatase (AP) was measured by kinetic method. The study included pre-and postmenarcheal girls with AIS and corresponding groups of scoliosis-free controls. Results In premenarcheal scoliotic girls, the levels of FSH, LH and oestradiol were lower; the levels of progesterone, oestrone and oestriol were higher; and the concentrations of oestrone and oestriol were similar compared to premenarcheal controls. Higher levels of RANKL, osteocalcin and AP were observed in premenarcheal adolescents with AIS compared to controls. The concentrations of FSH, LH, oestradiol, and progesterone in postmenarcheal girls with scoliosis were lower, oestrone were slightly lower and oestriol did not differ compared with the control group. Significantly higher levels of RANKL, osteoc alcin an d A P w ere o bserv ed i n postmenarcheal scoliotic adolescents compared with controls. Conclusions There is an interdependence between the concentration of oestradiol and development of scoliosis. Determination of estradiol may have diagnostic value in the screening of spinal pathologies associated with AIS.

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Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

Nada

Moreau

2017

Pathogenesis of Idiopathic Scoliosis

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Estrogen receptor polymorphism, estrogen content and idiopathic scoliosis in human: A possible genetic linkage

Cited by 40 publications

References 39 publications

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

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