Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

Nada, Dina; Moreau, Alain

doi:10.1007/978-4-431-56541-3_5

Cited by 1 publication

(2 citation statements)

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“…The occurrence of scoliosis in women is almost twice that of men, and this ratio reaches 10:1 for a Cobb angle of 30°. Considering the high prevalence of this disorder in women and the development of scoliosis along with sexual maturation, suggesting an involvement of estrogen and its receptors in the pathophysiology of AIS [ 41 ]. Low levels of circulating estrogen also led to decreased osteoblast differentiation, which impacts the stiffness, elasticity, and strength properties of bones, including mineralization [ 42 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

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Etiopathogenesis of adolescent idiopathic scoliosis (AIS): Role of genetic and environmental factors

Aulia,

Djufri,

Gatam

et al. 2023

Narra J

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Adolescent idiopathic scoliosis (AIS) has been known to be related closely to genetic factors. Higher prevalence of AIS among individuals with family history of scoliosis suggesting critical roles of genetic in the pathogenesis of AIS. However, evidence also suggested that environmental factors such as latitude and sun exposure also play a critical role in the pathogenesis of the disease. While genetic factors played an important role in the occurrence of AIS, environmental factors are more likely to affect the progression of the disease. Although the pathogenesis of AIS remains elusive, current knowledge suggests that genetic factors and its interaction with environmental factors are crucial in the development of the disease, explaining differences in clinical characteristics of AIS across the globe. The aim of this review is to summarize the current knowledge of genetic and environmental factors contributing to AIS and their interactions.

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Section: Etiopathogenesismentioning

confidence: 99%

“…Low levels of circulating estrogen also led to decreased osteoblast differentiation, which impacts the stiffness, elasticity, and strength properties of bones, including mineralization [ 42 ]. Decreased serum leptin levels in AIS patients has also been suggested to be associated with decreased bone mass [ 41 ].…”

Section: Etiopathogenesismentioning

confidence: 99%