Estrogen receptor levels and lipid peroxidation in hepatocellular carcinoma with hepatitis C virus infection

Shimizu, Ichiro; Inoue, Hiroshi; Yano, Mitsuyasu; Shinomiya, H; Wada, Satoshi; Tsuji, Yasuhiro; Tsutsui, Akemi; Okamura, Seisuke; Shibata, Hiroshi; Ito, Susumu

doi:10.1034/j.1600-0676.2001.210507.x

Cited by 35 publications

(21 citation statements)

References 29 publications

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“…But based on natural lifespan, long‐term survival rates were expected to be lower in elderly patients than in non‐elderly patients. It could be conceivable that this result was influenced by differences in baseline characteristics, including sex, alcohol habits, serum ALT levels and GGT levels, because these factors are associated with progression of hepatic fibrosis or carcinogenesis 26–30 …”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients

Takahashi

Mizuta

Kawazoe

et al. 2010

Hepatology Research

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Aim: This study was conducted to evaluate the efficacy and safety of radiofrequency ablation (RFA) therapy in elderly patients with hepatocellular carcinoma (HCC).Methods: Four hundred and sixty-one patients with naïve HCC, including 107 elderly (aged 375 years) patients, who were treated with RFA between 2000 and 2007, were enrolled. Baseline characteristics, survival/recurrence rates and complications after RFA were compared between elderly and non-elderly patients.Results: In the elderly group, the proportion of men, alcohol consumption, serum alanine aminotransferase and g-glutamyl transpeptidase levels were significantly lower compared with those in the non-elderly group. There were no differences in Child-Pugh grade and tumor characteristics between the two groups. The cumulative survival rates in the elderly group were 82% at 3 years and 61% at 5 years, which was equivalent to the non-elderly group. Similarly, no differences were observed in recurrence rates. In multivariate analysis, ChildPugh grade and tumor-related factors were significant factors associated with survival, but age was not. Although elderly patients had more extrahepatic comorbidities, their presence was not a factor associated with survival prognosis or complication after RFA.Conclusion: RFA treatment might be safe and effective in elderly patients, as well as non-elderly patients, with HCC.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients

Takahashi

Mizuta

Kawazoe

et al. 2010

Hepatology Research

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“…Immunohistochemical studies of SOD activity revealed that hepatocarcinogenesis induced by viral infection is closely related to the depletion of SOD in liver tissues (23). Further, HCC mediated by hepatitis C virus infection is associated with increased lipid peroxidation (24). Short term exposure to BaP has also been shown to increase lipid peroxidation in both serum and liver in an animal model (25).…”

Section: Discussionmentioning

confidence: 99%

Effects of Benzo(a)pyrene on the Expression of Heat Shock Proteins, Pro-inflammatory Cytokines and Antioxidant Enzymes in Hepatic Tumors Induced by Rat Hepatoma N1-S1 Cells

et al. 2011

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Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat. BaP causes harmful oxidative effects on cell development, growth and survival through an increase in membrane lipid peroxidation, oxidative DNA damage and mutagenesis. Therefore, the present study was conducted to evaluate the synergistic effects of BaP on oxidative stress in hepatic tumors. In this study, we established a hepatic tumor model by injecting rat hepatoma N1-S1 cells into healthy rats. Changes in the abundance of heat shock proteins (HSPs), antioxidant enzymes and pro-inflammatory cytokines were then investigated by western blot analysis. In addition, we examined changes in oxidative stress levels. Injection of N1-S1 cells or concomitant injection of BaP and N1-S1 cells resulted in the formation of hepatic tumors at the injection site. Evaluation of rat plasma reveals that hepatic tumors induced by BaP and N1-S1 cells expresses higher levels of Hsp27, superoxide dismutase (SOD), and tumor necrosis factor-α (TNF-α) when compared to those induced by N1-S1 cells only. The collective results of this study suggest that BaP exerts synergistic effects on the expression of HSP, cytokines and antioxidant enzymes in hepatic tumors induced by rat hepatoma N1-S1 cells.

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“…Logistic regression identified an age greater than the menopausal age, male gender, a decreased ER level, and an increase in lipid peroxidation products as variables that were independently associated with the development of HCC in HCV-related cirrhotics. 8 Moreover, it has been reported that variant ERs are expressed in HCC patients and to a greater extent in male patients with chronic liver disease than in female subjects, even at an early stage of chronic liver disease. 83,84 The occurrence of variant ERs leads to the loss of estrogen responsiveness.…”

Section: Er Status In Hccmentioning

confidence: 99%

“…4,5 Among patients with cirrhosis and HCC, the male : female ratio is in the range of 2.3:1-2.6:1. [6][7][8] Moreover, there is a growing concern for the development of non-alcoholic fatty liver disease (NAFLD) in clinical hepatology. Although in most cases fatty liver does not progress to more severe liver diseases, approximately 15-20% of patients have histological signs of fibrosis and necroinflammation, indicating the presence of non-alcoholic steatohepatitis (NASH).…”

Section: Introductionmentioning

confidence: 99%

Protection of estrogens against the progression of chronic liver disease

Shimizu

Ito

2007

Hepatology Research

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Hepatitis C virus infections are recognized as a major causative factor of chronic liver disease. A characteristic feature of chronic hepatitis C, alcoholic liver disease and non-alcoholic fatty liver disease is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes, which, in turn, activates hepatic stellate cells (HSCs). HSCs are also thought to be the primary target cells for inflammatory and oxidative stimuli, and to produce extracellular matrix components. Based on available clinical information, chronic hepatitis C appears to progress more rapidly in men than in women, and cirrhosis is predominately a disease of men and postmenopausal women. Estradiol is a potent endogenous antioxidant. Hepatic steatosis was reported to become evident in an aromatase-deficient mouse and was diminished in animals after treatment with estradiol. Our previous studies showed that estradiol suppressed hepatic fibrosis in animal models, and attenuated HSC activation by suppressing the generation of reactive oxygen species in primary cultures. Variant estrogen receptors were found to be expressed to a greater extent in male patients with chronic liver disease than in female subjects. A better understanding of the basic mechanisms underlying the gender-associated differences observed in the progression of chronic liver disease would provide valuable information relative to the search for effective antifibrogenic therapies.

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Estrogen receptor levels and lipid peroxidation in hepatocellular carcinoma with hepatitis C virus infection

Cited by 35 publications

References 29 publications

Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients

Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients

Effects of Benzo(a)pyrene on the Expression of Heat Shock Proteins, Pro-inflammatory Cytokines and Antioxidant Enzymes in Hepatic Tumors Induced by Rat Hepatoma N1-S1 Cells

Protection of estrogens against the progression of chronic liver disease

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