Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients

Lee, D.-G.; Kim, T.-W.; Kang, Seok-Min; Kim, S.T.

doi:10.1016/j.ijom.2005.06.009

Cited by 38 publications

(24 citation statements)

References 20 publications

(19 reference statements)

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“…No significant differences were observed between the patient and control groups in terms of haplotype and genotype frequencies (p > .05, Table 1). The fourth possible haplotype, pX, was not observed, as has been reported previously 5,12,21 .…”

Section: Resultssupporting

confidence: 75%

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Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Kang

Lee

et al. 2007

International Journal of Oral and Maxillofacial Surgery

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Section: Resultssupporting

confidence: 75%

“…In the previous study 12 , the Px haplotype was found to be associated with an altered mandibular dimension. It would appear that ERa polymorphisms contribute to mandibular dimension and pain susceptibility in female symptomatic TMJ OA patients, but different haplotypes are involved.…”

Section: Discussionmentioning

confidence: 78%

Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Kang

Lee

et al. 2007

International Journal of Oral and Maxillofacial Surgery

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“…Lee ve ark. 'nın (11) yaptıkları çalışmada östrojenin fibrokartilaj sentezi üze-rine olumsuz etkilerinden dolayı TME şikâyetlerinin kadınlarda daha sık görüldüğünü bildirmişlerdir. Ça-lışmamızdaki hastalar yalnızca artrosentez yapılan hastalar olsa da literatüre benzer kadın/erkek oranın-daydı.…”

Section: Discussionunclassified

Evaluation Of The Efficacy Of Temporomandibular Joint Arthrocentesis With Clinical And Radiological Findings

Akdağ¹,

Koplay²,

Tosun³

2018

Okmeydani Medical Journal

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“…50 The rs1643821 intron SNP contributes to the susceptibility for osteoporotic fracture in postmenopausal Chinese women. 51 Since the incidence of TMD in asymmetry group 4 is relatively low, rs1643821 may be contributing to development of this type of asymmetry through variations in bone mineral density with growth, rather than by specific problems in the TMJ.…”

Section: Discussionmentioning

confidence: 99%

ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders

Chung

Richards

Nicot

et al. 2017

American Journal of Orthodontics and Dentofacial Orthopedics

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Introduction We investigated if ACTN3, ENPP1, ESR1, PITX1 and PITX2 genes which contribute to sagittal and vertical malocclusion also contribute to facial asymmetries and TMD before and after orthodontic and orthognathic surgery treatment. Methods One hundred seventy four dentofacial deformity patients were diagnosed as symmetric or subdivided into four asymmetric groups according to PA cephalometric measurements. TMD exam diagnosis and Jaw Pain and Function-(JPF) questionnaires assessed presence and severity of TMD. Results Fifty two % of patients were symmetric and forty eight % asymmetric. The asymmetry classification demonstrated significant cephalometric differences between symmetric and asymmetric groups, and across the four asymmetric subtypes: Group 1 - mandibular body asymmetry, Group 2 - ramus asymmetry, Group 3 - atypical asymmetry and Group 4 - “C-shaped” asymmetry. ENPP1 SNP-rs6569759 associated with asymmetry Group 1(p=0.004), and rs858339 with asymmetry Group 3 (p=0.002). ESR1 SNP-rs164321 associated with asymmetry Group 4 (p=0.019). These results are confirmed by Principal Component Analysis (PCA) that showed three principal components explaining almost 80% of the variation seen in the studied group. PC1 and PC2 were associated with ESR1 SNP-rs3020318 (p<0.05). Diagnoses of disc displacement with reduction, masticatory muscle myalgia and arthralgia were highly prevalent in the asymmetry groups and all had strong statistical association to ENPP1 rs858339. The average JPF scores for asymmetric subjects before surgery (JPF=7), were significantly higher than symmetric subjects (JPF=2). Patients with asymmetry Group 3 reported the highest preoperative JPF scores and Group 2 and 3 were most likely to be cured of TMD one year after treatment. Conclusions PA cephalometrics can classify asymmetry into distinct groups; identify probability of TMD and genotype associations. Orthodontic and orthognathic treatment of facial asymmetry is very effective at eliminating TMD in most patients.

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Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients

Cited by 38 publications

References 20 publications

Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Evaluation Of The Efficacy Of Temporomandibular Joint Arthrocentesis With Clinical And Radiological Findings

ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders

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