Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Kang, Seok-Min; Lee, D.-G.; Jh, Choi; Kim, S.T.; Kim, Y.-K.; Ahn, Hyung‐Joon

doi:10.1016/j.ijom.2006.12.004

Cited by 89 publications

(74 citation statements)

References 19 publications

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“…With the anatomical studies of the location of ERs in mind, one may speculate that ERs are involved not only in ER-dependent cancers but also in cardiovascular disease, osteoporosis, neurological disorders and disorders of the immune system (Nilsson et al, 2004). Mutations, deletions and polymorphisms have been reported in the ER genes and they have also, to some extent, been related to different disorders including certain pain conditions (Kang et al, 2007;Nilsson et al, 2004;Ribeiro-Dasilva et al, 2009;Roh et al, 2012;Ushiyama et al, 1998). Since the naturally occurring ligands of the ER are agonists, the actions of co-repressors are also important in the prevention of a chronically high expression of ER-inducible genes.…”

Section: Are the Effects Of Estrogens On Pain Transmission Of Any Sigmentioning

confidence: 99%

Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

104

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Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

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Section: Are the Effects Of Estrogens On Pain Transmission Of Any Sigmentioning

confidence: 99%

Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

104

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“…For molecular studies, whole blood samples were collected in sterile tripotassium ethylene diamine tetraacetic acid 3 (K + EDTA) vacutainer tubes [29,30]. DNA was extracted from peripheral blood leucocytes from the freshly withdrawn whole blood, using GeneJET™ Genomic DNA Purification Kit, Fermentas [31].…”

Section: Molecular Studies For the Detection Of I/d Polymorphism Of Amentioning

confidence: 99%

Polymorphisms of Renin Angiotensin System Genes in Uterine Leiomyomas Among Egyptian Females

Gomaa¹,

Zaki²,

El-Attar³

et al. 2015

J Clin Gynecol Obstet

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Background: Uterine leiomyomas are the most common gynecological benign myometrial neoplasms. They have been associated with infertility and recurrent abortion as well as obstructed labor and post-partum hemorrhage. They are the most important indication for hysterectomy. The renin angiotensin system (RAS), in particular angiotensin type 1 receptor (AT1R) and to a lesser extent angiotensin II, angiotensin converting enzyme (ACE) and angiotensin type 2 receptor (AT2R), are often upregulated during the progression from normal to malignant phenotypes indicating a possible correlation between RAS and tumor progression. The present study investigated the association of A1166C single nucleotide polymorphism (SNP) of AT1R gene and insertion deletion (I/D) polymorphism of ACE gene with uterine leiomyomas in Egyptian females.

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“…Zatim, istraživanja koja su se odnosila na izučavanje gena su ukazala da određeni genski polimorfizam estrogenskih receptora ( Erα) je povezan sa vremenski ranijom pojavom reumatoidnog artritisa kod žena nego kod muškaraca, zatim da je veći rizik od pojave osteoartritis TMZ koji je praćen intenzivnijim bolom kod žena u odnosu na muškarce [16].…”

Section: Epidemiološka Istraživanjaunclassified

“…Naknadno uvođenje estrogena je značajno uticalo na histomorfometrijske parametre ranije registrovane, odnosno registrovane kada je nivo estrogena bio niži [24]. Uloga estrogena u remodelaciji koštanih struktura TMZ se potvrđuje i činjenicom da je češće prisustvo simptoma osteoartritisa TMZ kod žena u odnosu na muškarce [5,6,16]. Mehanizam rasta i remodelacije kosti pomoću estrogena na molekularnom nivou se dijelom objašnjava uticajem estrogen na diferencijaciju osteoblasta u smislu smanjenja ćelijske proliferacije kao i na ekstracelularni matriks [26].…”

Section: Estrogen I Njegov Uticaj Na Morfologiju I Funkciju Temporomaunclassified

Uticaj estrogena na pojavu temporomandibularnih disfunkcija

Ivković

Božović

Popović-Grubač

et al. 2012

Biomedicinska istraž.

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Kratak sadržajTemporomandibularne disfunkcije (TMD) su grupa kliničkih stanja koja su praćena bolom i poremećajem funkcija orofacijalnog sistema. Nastaju kao posljedica narušavanja normalnog funkcionisanja i/ili oštećenja strukture, najčešće, temporomandibularnih zglobova i/ili mastikatornih mišića, glavnih komponenata orofacijalnog sistema. Smatra se da su žene izložene većem riziku od pojave TMD u poređenju sa muškarcima, a razlog za žensku predominaciju još uvijek nije u potpunosti razjašnjen. Uticaj pola i starosne dobi na distribuciju TMD upućuju na moguću vezu između patogeneze TMD i hormonske osovine kod žena sa posebnim osvrtom na uticaj estrogena.U ovom preglednom radu sagledana je uloga estrogena u patofiziologiji TMD. Prvo je na osnovu epidemioloških istraživanja ukazano na povezanost između nivoa estrogena i učestalosti TMD. Zatim je prikazan uticaj estrogena na morfologiju i funkciju temporomandibularnog zgloba, kao i uticaj estrogena na mehanizme kontrole bola.Ključne riječi: temporomandibularne disfukcije, temporomandibularni zglob, estrogen, bol UvodTerminom "temporomandibularne disfunkcije" (TMD) je obuhvaćena grupa različitih kliničkih stanja koja su praćena bolom i poremećajem funkcija orofacijalnog sistema. TMD nastaju kao posljedica narušavanja normalnog funkcionisanja i/ili oštećenja strukture, najčešće, temporomandibularnih zglobova (TMZ) i/ ili mastikatornih mišića, glavnih komponenata orofacijalnog sistema. Kardinalni znaci i simptomi TMD su: bol u mastikatornim mišićima, preaurikularnoj regiji i/ili u predjelu TMZ koji se pogoršava funkcijama orofacijalnog sistema, zatim palpatorna osjetljivost ovih regiona, ograničena i/ili asimetrična kretnja donje vilice, kao i prisusutvo karakterističnih zvučnih efekata u TMZ u vidu pucketanja ili krepitacija [1][2][3]. Kako je muskuloskeletni bol kod TMD hroničnog toka, ova bolna stanja su često praćena psihičkim Adresa autora: Doc. dr Nedeljka Ivković

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Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

Cited by 89 publications

References 19 publications

Estrogenic influences in pain processing

Estrogenic influences in pain processing

Polymorphisms of Renin Angiotensin System Genes in Uterine Leiomyomas Among Egyptian Females

Uticaj estrogena na pojavu temporomandibularnih disfunkcija

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