Estrogen receptor-alpha isoforms are the main estrogen receptors expressed in non-small cell lung carcinoma

Pelekanou, Vasiliki; Anastasiou, Eleftheria; Bakogeorgou, Efstathia; Notas, George; Kampa, Marilena; García-Milián, Rolando; Lavredaki, Katerina; Moustou, Eleni; Chinari, Georgia; Arapantoni, P.; O’Grady, Anthony; Georgoulias, V.; Tsapis, Andréas; Stathopoulos, Efstathios N.; Castanas, Elias

doi:10.1016/j.steroids.2018.01.008

Cited by 10 publications

(6 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 (top), the strongest edge with weight of 34 is found between breast cancer and lung cancer. The finding provides additional evidence to the literature: it has been recently reported that lung tumors express estrogen receptor alpha, which is a common trait in >70% of breast tumors, and whose activation expresses pathways related to cell proliferation and metastasis, 4 common elements shared with pathways identified in breast cancer. 5 Also, a connection between breast cancer and thyroid cancer appears (weight = 7), a relationship that has attracted substantial attention in the medical research community.…”

Section: Resultssupporting

confidence: 64%

A data driven approach reveals disease similarity on a molecular level

et al. 2019

Self Cite

View full text Add to dashboard Cite

Could there be unexpected similarities between different studies, diseases, or treatments, on a molecular level due to common biological mechanisms involved? To answer this question, we develop a method for computing similarities between empirical, statistical distributions of high-dimensional, low-sample datasets, and apply it on hundreds of -omics studies. The similarities lead to dataset-to-dataset networks visualizing the landscape of a large portion of biological data. Potentially interesting similarities connecting studies of different diseases are assembled in a disease-to-disease network. Exploring it, we discover numerous non-trivial connections between Alzheimer’s disease and schizophrenia, asthma and psoriasis, or liver cancer and obesity, to name a few. We then present a method that identifies the molecular quantities and pathways that contribute the most to the identified similarities and could point to novel drug targets or provide biological insights. The proposed method acts as a “statistical telescope” providing a global view of the constellation of biological data; readers can peek through it at: http://datascope.csd.uoc.gr:25000/.

show abstract

Section: Resultssupporting

confidence: 64%

A data driven approach reveals disease similarity on a molecular level

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…ERβ, an important member of the nuclear receptor protein family as well as a crucial transcription factor, is linked to the survival of breast cancer patients [ 73 – 75 ]. Recently, ERβ was shown to affect the progression of NSCLC by promoting the proliferation, invasion, and metastasis of NSCLC cells [ 38 , 40 , 48 ]. Many studies have focused on the pathological role of ERβ, which can be activated by estrogen or other ligands and coactivators, in the development of lung cancer, especially NSCLC [ 76 – 79 ].…”

Section: Discussionmentioning

confidence: 99%

“…As members of the nuclear receptor protein family, ERs are found mainly in the nucleus and can be activated by estrogen as well as other coactivators [34][35][36]. ERα and ERβ are detected in normal and tumor lung tissues [37][38][39], and affect survival in lung cancer patients through promoting the proliferation of cancer cells [40][41][42]. Recent evidence suggests that ERα and ERβ are expressed in NSCLC cell lines and tissues and play important roles during cancer development [37,[43][44][45][46].…”

Section: Introductionmentioning

confidence: 99%

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells

Chen

Jiang

et al. 2020

Cell Commun Signal

View full text Add to dashboard Cite

Introduction Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) is involved in the progression of non-small cell lung cancer (NSCLC), however, the role of ERβ in the response to radiotherapy in lung cancer remains elusive. In the present study, we investigated the mechanism underlying ERβ-mediated transcriptional activation and radioresistance of NSCLC cells. Methods Quantitative real-time PCR, western blot and immunohistochemistry were used to detect the expression of CLPTM1L, ERβ and other target genes. The mechanism of CLPTM1L in modulation of radiosensitivity was investigated by chromatin immunoprecipitation assay, luciferase reporter gene assay, immunofluorescence staining, confocal microscopy, coimmunoprecipitation and GST pull-down assays. The functional role of CLPTM1L was detected by function assays in vitro and in vivo. Results CLPTM1L expression was negatively correlated with the radiosensitivity of NSCLC cell lines, and irradiation upregulated CLPTM1L in radioresistant (A549) but not in radiosensitive (H460) NSCLC cells. Meanwhile, IR induced the translocation of CLPTM1L from the cytoplasm into the nucleus in NSCLC cells. Moreover, CLPTM1L induced radioresistance in NSCLC cells. iTRAQ-based analysis and cDNA microarray identified irradiation-related genes commonly targeted by CLPTM1L and ERβ, and CLPTM1L upregulated ERβ-induced genes CDC25A, c-Jun, and BCL2. Mechanistically, CLPTM1L coactivated ERβ by directly interacting with ERβ through the LXXLL NR (nuclear receptor)-binding motif. Functionally, ERβ silencing was sufficient to block CLPTM1L-enhanced radioresistance of NSCLC cells in vitro. CLPTM1L shRNA treatment in combination with irradiation significantly inhibited cancer cell growth in NSCLC xenograft tumors in vivo. Conclusions The present results indicate that CLPTM1L acts as a critical coactivator of ERβ to promote the transcription of its target genes and induce radioresistance of NSCLC cells, suggesting a new target for radiosensitization in NSCLC therapy.

show abstract

“…It is now recognized that ERa is a key regulator of energy homeostasis and glucose metabolism and that the ERa pathway might represent a potential therapeutic target for the prevention or treatment of insulin resistance, type 2 diabetes mellitus, and non-alcoholic fatty liver diseases [16,32]. On the other hand, ERa is linked with a variety of cancers and metastases, including breast cancer, cervical cancer, lung carcinoma, and prostate cancer [33][34][35][36].…”

Section: Eramentioning

confidence: 99%

Estrogen and estrogen receptors in kidney diseases

Chen

2021

Renal Failure

View full text Add to dashboard Cite

Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney. For instance, they are crucial in maintaining mitochondrial homeostasis and modulating endothelin-1 (ET-1) system in the kidney. Estrogen takes part in the kidney repair and regeneration via its receptors. Estrogen also participates in the regulation of phosphorus homeostasis via its receptors in the proximal tubule. The ERa polymorphisms have been associated with the susceptibilities and outcomes of several renal diseases. As a consequence, the altered or dysregulated estrogen/ERs signaling pathways may contribute to a variety of kidney diseases, including various causes-induced AKI, diabetic kidney disease (DKD), lupus nephritis (LN), IgA nephropathy (IgAN), CKD complications, etc. Experimental and clinical studies have shown that targeting estrogen/ERs signaling pathways might have protective effects against certain renal disorders. However, many unsolved problems still exist in knowledge regarding the roles of estrogen and ERs in distinct kidney diseases. Further research is needed to shed light on this area and to enable the discovery of pathwayspecific therapies for kidney diseases.

show abstract

Estrogen receptor-alpha isoforms are the main estrogen receptors expressed in non-small cell lung carcinoma

Cited by 10 publications

References 63 publications

A data driven approach reveals disease similarity on a molecular level

A data driven approach reveals disease similarity on a molecular level

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells

Estrogen and estrogen receptors in kidney diseases

Contact Info

Product

Resources

About