Estrogen raises the sweating threshold in postmenopausal women with hot flashes

Freedman, Robert R.; Blacker, C. P.

doi:10.1016/s0015-0282(01)03009-6

Cited by 100 publications

(59 citation statements)

References 22 publications

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“…The development of sweating as a side effect of SER (11% of the SER-treated sample) may also have minimized the likelihood of demonstrating benefit in some subjects. The central mechanisms controlling idiopathic or emotional sweating are not well understood, but may be influenced by both monoaminergic inputs [Altman and Schwartz, 2002;Holzle, 2002] and estrogen levels [in women;Freedman and Blacker, 2002]. Benzodiazepines have been shown to be more effective than SSRIs and tricyclic antidepressants in reducing somatic anxiety symptoms in GSAD, although their effect on sweating in particular has not been evaluated.…”

Section: Discussionmentioning

confidence: 99%

Multidimensional effects of sertraline in social anxiety disorder

et al. 2006

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Clinical trials of social anxiety disorder (SAD) have largely focused on the effect of treatment on symptoms of fear and avoidance, while neglecting the third clinically relevant dimension, physiological arousal. Data were combined from two previously reported placebo-controlled trials of sertraline in the treatment of moderate-to-severe generalized SAD. Efficacy was evaluated using the Brief Social Phobia Scale (BSPS). Three hundred forty-six subjects were randomized to 12-13 weeks of treatment with sertraline and 273 subjects to placebo. Following treatment, significant improvement was noted in favor of sertraline on the full BSPS (P < .001), as well as on each of the individual BSPS subscales: fear (P = .001); avoidance (P < .0001); and physiological arousal (P < .0001). Of the physiological symptoms assessed, the treatment advantage with sertraline was maintained for blushing (P < .003) and palpitations (P < .03), but not for trembling and sweating. These results confirm the efficacy of treatment with a selective serotonin reuptake inhibitor (SSRI), sertraline, across the spectrum of fear, avoidance, and physiological arousal in generalized SAD (GSAD). Among common physiological symptoms in this population, blushing and palpitations appear more treatment responsive than trembling and sweating to acute treatment with sertraline.

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Section: Discussionmentioning

confidence: 99%

Multidimensional effects of sertraline in social anxiety disorder

et al. 2006

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“…Whilst HT reduces hot flushes it also affects thermoregulatory control mechanisms via lowering core body temperature and altering the threshold at which cutaneous vasodilation and sweating responses are initiated 21,22 . If the thermoregulatory control system can be altered with exercise training in symptomatic post-menopausal women, this may also reduce the frequency of hot flushes.…”

Section: Introductionmentioning

confidence: 99%

Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control

et al. 2016

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Objectives: Post-menopausal hot flushes occur due to a reduction in oestrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. We aimed to determine if improving thermoregulatory control and vascular function with exercise training alleviated hot flushes.Methods: Twenty one symptomatic females completed a 7-day hot flush questionnaire and underwent brachial artery flow-mediated dilation and a cardiorespiratory fitness test. Sweat rate and skin blood flow temperature thresholds and sensitivities, and middle cerebral artery velocity (MCAv) was measured during passive heating. Females performed 16-weeks of supervised exercise training or control, and measurements were repeated. Conclusions: Exercise training that improves cardiorespiratory fitness reduces self-reported hot flushes. Improvements are likely mediated through greater thermoregulatory control in response to increases in core temperature and enhanced vascular function in the cutaneous and cerebral circulations. Results

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“…Biologically, hot flashes are associated with declining levels of endogenous estrogens which result in a lower internal temperature threshold for the onset of sweating (Freedman and Blacker, 2002). Hypothalamic a-2-adrenergic receptors appear to be responsible for the heat dis-sipation responses associated with hot flashes (Freedman et al, 1990) in conjunction with a narrowed thermoneutral zone (Freedman, 2005;Freedman and Krell, 1999).…”

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confidence: 99%

Patterns of occurrence and concordance between subjective and objective hot flashes among Muslim and Hindu women in Sylhet, Bangladesh

Sievert

Begum

Sharmeen

et al. 2008

American J Hum Biol

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This study examined the pattern of occurrence and the rate of concordance between objective hot flashes measured by sternal skin conductance and the subjective experience of "gorom vap laga" (feeling steaming hot) among Muslim and Hindu women living in Sylhet, Bangladesh. Participants were aged 40-55, not pregnant or lactating, not using hormone therapy, and with no history of hysterectomy. Thirty women wore an ambulatory hot flash monitor for 8 h on average, from mid-morning to early evening. True positive, false negative, and false positive measures of hot flashes were examined in relation to demographic, reproductive, and lifestyle variables. On body diagrams, women were most likely to indicate hot flashes on the top of their head (64%) and upper chest (68%). The greatest number of objective hot flashes occurred during the hour of 17:00, perhaps due to the heat of the day, and the clothing and activity associated with prayer. Muslim participants demonstrated more objective hot flashes per woman than Hindu participants (1.5 vs. 0.1, P < 0.05), and Muslims had more false positive measures (86%) compared with Hindu participants (0%, P = 0.06). Among all women who reported subjective hot flashes (n = 19), the proportion of true positive scores was 19%. Overall, the frequency of objective hot flashes was low compared with reports from studies in the United States. The pattern of sweating assessed by body diagrams was not associated with variation in hot flash experience.

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Estrogen raises the sweating threshold in postmenopausal women with hot flashes

Cited by 100 publications

References 22 publications

Multidimensional effects of sertraline in social anxiety disorder

Multidimensional effects of sertraline in social anxiety disorder

Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control

Patterns of occurrence and concordance between subjective and objective hot flashes among Muslim and Hindu women in Sylhet, Bangladesh

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