Estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (Eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells

Klann, Anja E.; Levy, G Fernández; Lutz, Ilka; Müller, Christian; Kloas, Werner; Hildebrandt, Jan‐Peter

doi:10.1016/j.envres.2004.07.004

Cited by 41 publications

(20 citation statements)

References 15 publications

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“…In a previous study, we have suggested that X. laevis, a well-developed animal model for developmental biology, might be an alternative animal model for studying endocrine disruptors because of their sensitivity to endocrine effects and a rich literature on reproduction and development (Qin et al, 2003). The sensitivity of X. laevis to endocrine disruptors has attracted attention (Kloas, 2002;Klann et al, 2005), and increasingly, researchers are beginning to use X. laevis to study endocrine disruptors (Hayes et al, 2002;Pickford and Morris, 2003;van Wyk et al, 2003). Based on our results, here, we suggest X. laevis might be alternative model animal to study reproductive toxicity of phytoestrogens involving endocrine disruption.…”

Section: Discussionmentioning

confidence: 99%

Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens

et al. 2006

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“…These compounds are not only extensively used in PCPs but also commonly used in a wide variety of industrial goods as textiles, paints or plastics to prevent photodegradation of polymers and pigments [103]. However, recent concern has risen due to their potential for endocrine disruption and development of toxicity [104][105][106][107]. UV filters enter the aquatic environment directly as a result of recreational activities when they are washed off from the skin or indirectly through wastewater resulting from the use of PCPs, washing clothes and industrial discharges.…”

Section: Uv Filters (Sunscreens)mentioning

confidence: 99%

Introduction: Personal Care Products in the Aquatic Environment

Molins-Delgado

Díaz˗Cruz

Barceló

2014

The Handbook of Environmental Chemistry

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This chapter presents an overview of the main aspects relating to the occurrence and impact of ingredients in personal care products to the aquatic environment: methodologies of analysis, prevalence data, elimination processes, threats to the aquatic ecosystem, effects on biota and legislation with a special focus in European regulation. Water is a valuable resource for the environment as well as for human activities. Although it covers most of the Earth's surface, the amount of usable water is finite. Since ancient times until now, the use of water in human activities has been rapidly increasing along with the increase of the population, producing a continuous release of pollutants into the aquatic environment. Personal care products are a widely used group of substances that have been raising concerns during the last decades due to its continuous release into the environment and its proven effects (mostly on in vitro and in vivo assays) as a threat to all kinds of living organisms. Recent studies suggest that its continuous application on the skin or the intake of contaminated food may cause some concerning hazardous effects in human beings. In order to ensure the protection of this key ecosystem, a series of worldwide initiatives have been taking place during the last two decades, impelling monitoring programmes and governmental regulations worldwide. The common grounds of the European Union establish a series of regulations, such as the Water

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“…Hamann et al, (2006) observed that 4-MBC was a potent inhibitor of the pituitary-thyroid-axis due to the fact that TSH serum levels were significantly elevated and the weight of the thyroid glands that was remarkably increased. Beside these facts, the 4-MBC may be a potentially harmful substance for water-dwelling animals when present in the environment at micromolar concentrations (Klann et al, 2005). The present study examined the influence of two different cosmetic vehicles in cutaneous permeation of 4-Methylbenzylidenecamphor by in vitro experiment using Franz cells.…”

Section: Introductionmentioning

confidence: 99%

Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro

Sasson

Sato

Beletti³

et al. 2009

Braz. arch. biol. technol.

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The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was

show abstract

Estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (Eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells

Cited by 41 publications

References 15 publications

Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens

Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phytoestrogens

Introduction: Personal Care Products in the Aquatic Environment

Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro

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