Estrogen Induction of LH Release in the Rhesus Monkey12

Yamaji, Taiki; Dierschke, Donald J.; Hotchkiss, J.; Bhattacharya, A.N.; Surve, A. H.; Knobil, E.

doi:10.1210/endo-89-4-1034

Cited by 148 publications

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“…measurements did not change, possibly because of maximal stimulation by LH throughout the E, course. The results of the study in this physiologically castrate man are qualitatively similar to those reported by Yamaji et al (18) in the postpubertal, castrate, male rhesus monkey.…”

Section: A D U L T Mensupporting

confidence: 90%

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Gonadotropin and Testosterone Measurements after Estrogen Administration to Adult Men, Prepubertal and Pubertal Boys, and Men with Hypogonadotropism: Evidence for Maturation of Positive Feedback in the Male

Kulin

Reiter

1976

Pediatr Res

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ExtractNineteen male subjects were given five daily injections of 17P-estradiol and circulating levels of estradiol (E,), testosterone (T), and gonadotropins were determined by radioimmunoassay before, during, and after the steroid course. Peak levels of E, attained during the 5 days of treatment ranged from 173-577 pg/ml. Four of seven normal adult men and one castrate man demonstrated suppression of follicle-stimulating hormone ( FSH ) and luteinizing hormone (LHI with a subseauent rise in LH (oositive feedback) while E, levels remained elevated. A rise in T ;is associated with the L H increment in the four normal men. Nine pre-, early, or midpubertal boys and two men with hypogonadotropic hypogonadism displayed only gonadotropin soppressiorl after E, administration. The difference in LH response to estrogen (i.e., positive feedback) between the adult men with normal or elevated gonadotropin levels as compared with the endocrinologically normal boys is significant ( P < 0.01 ). SpeculationPositive feedback between estrogen and 1.H is present in intact adult men, although the magnitude and consistency of this response is less than in women. Testosterone in men may act like progesterone in the female rhesus monkey to blunt the magnitude of the L H rise during estrogen administration. The potential for positive feedback appears to be a maturational event occurring during puberty in men as well as in women.Sexual differentiation of the brain and the consequent ability of the female of the species to exhibit regular ovulatory cycles exists in certain rodents and can be influenced by neonatal exposure to a number of steroid hormones. In contrast, fetal and neonatal exposure of the brain of the rhesus monkey to gonadal steroids does not appear to influence the basic hypothalamic mechanisms controlling reproduction (4).The ability of estrogen to induce the release of LH, termed positive feedback, has been demonstrated in the intact, adult female and in the postpubertal, castrate male, and female rhesus monkey (18). Such effects of estrogen have not been found in the intact, adult male rhesus. LH re!ease after estrogen administration has also been demonstrated in adult women (9, 11) but not in sexually immature girls ( I I). The onset of positive feedback appears to be a late pubertal event in the female (I I). We should like to present evidence that a stimulatory luteinizing hormone response to exogenous estrogen is also a maturational event in men. M A T E R I A L S A N D M E T H O D S SUBJECTSSeven normal, adult men (ages 20-22) and one male (age 21) with the syndrome of vanishing testes (1) were hospitalized for study at the Clinical Center of the National Institutes of Health. Each patient was given five daily intramuscular injections of 10 or 15 pg/kg body weight of 17P-estradiol (E,) (20) and blood samples were obtained every 12-24 hr before, during, and after the estrogen course (see Table 1).Nine endocrinologically normal boys between the ages of 7 and 18 were studied in the course of evaluation for short stat...

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Section: A D U L T Mensupporting

confidence: 90%

“…The ability of estrogen to induce the release of LH, termed positive feedback, has been demonstrated in the intact, adult female and in the postpubertal, castrate male, and female rhesus monkey (18). Such effects of estrogen have not been found in the intact, adult male rhesus.…”

mentioning

confidence: 99%

Gonadotropin and Testosterone Measurements after Estrogen Administration to Adult Men, Prepubertal and Pubertal Boys, and Men with Hypogonadotropism: Evidence for Maturation of Positive Feedback in the Male

Kulin

Reiter

1976

Pediatr Res

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“…Moreover, high estradiol levels during the early luteal phase could result in a short luteal phase and compromise fertility (Hutchison et al, 1987). Since estradiol can stimulate an LH surge in ovariectomized monkeys (Terasawa, 1985;Mello et al, 1992), and in gonadally intact females during the follicular phase of the menstrual cycle (Yamaji et al, 1971;Ordog et al, 1998), we hypothesized that cocaine-induced increases in estradiol levels might account, in part, for the increase in LH release that has been consistently observed (Mello et al, 2000). Consistent with this notion, an antecedent increase in estradiol levels is essential for the periovulatory LH surge in gonadally intact females at mid-cycle (Hotchkiss and Knobil, 1994).…”

Section: Introductionmentioning

confidence: 92%

The Effects of Cocaine on Gonadal Steroid Hormones and LH in Male and Female Rhesus Monkeys

Mello

Mendelson

Negus

et al. 2004

Neuropsychopharmacol

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Cocaine stimulates significant increases in estradiol, testosterone (T), and luteinizing hormone (LH) in rhesus monkeys, but the temporal interactions between the gonadal steroid hormones and LH have not been determined. The effects of i.v. cocaine (0.8 mg/kg) or saline placebo administration on estradiol, T, and LH were compared in follicular phase female and male rhesus monkeys. Samples for hormone analysis were collected at 2-min intervals for 20 min, then at 10-min intervals for 50 min. Peak plasma cocaine levels were detected at 4 min and pharmacokinetic analyses showed no significant gender differences. Baseline hormone levels were equivalent before saline and cocaine administration, and saline did not alter LH or estradiol levels. In females, when baseline estradiol levels were low (o100 pg/ml), LH increased significantly within 8 min after cocaine administration (Po0.05), but when baseline estradiol levels were high (4100 pg/ml), LH levels did not change significantly after cocaine administration. Estradiol and T increased significantly after LH, within 16 min after cocaine administration (Po0.01-0.001). In males, significant LH increases were detected at 16 min after cocaine administration (Po0.05-0.001), but estradiol and T did not change significantly. Thus, cocaine may stimulate significant increases in estradiol and T in females but not in males. These rapid hormonal changes may contribute to cocaine's abuse-related effects, as well as to disruptions of the menstrual cycle during chronic cocaine administration.

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“…Failure of the positive feedback effect of oestrogens on LH release has been associated with ovarian acyclicity in post-partum ewes (Wright and Findlay 1977), women (Baird et al 1979), monkeys (Yamaji et al 1971) and cows (Radford et al 1978), and in non-parturient amenorrhoeic women (Glass et al 1975;Aono et al 1976).…”

Section: Introductionmentioning

confidence: 99%

Pituitary Responsiveness to LH-RH in Post-partum Ewes Treated With Oestradiol-17ß and Failing to Show a Plasma LH Surge

Wright¹,

Stelmasiak²,

Wa³

1980

Aust. Jnl. Of Bio. Sci.

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Oestradiol-17 p (40 fig intravenously) failed to elicit a surge in plasma LH levels by 13 h after administration in 64 % (16 out of 25) Merino ewes about 30 days post partum in the anoestrous season.LH-RH responsiveness and LH-RH priming effect were significantly greater in these ewes than in similar post-partum (n = 9) and non-parturient ewes (n = 3) not treated with oestradiol. This suggests that the failure of the oestrogen-positive feedback effect on LH release in post-partum ewes is not due to a failure of oestradiol action on the pituitary increasing pituitary responsiveness to LH-RH and LH-RH priming effect, but could be due to inadequate release of LH-RH from the hypothalamus.

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Estrogen Induction of LH Release in the Rhesus Monkey12

Cited by 148 publications

References 0 publications

Gonadotropin and Testosterone Measurements after Estrogen Administration to Adult Men, Prepubertal and Pubertal Boys, and Men with Hypogonadotropism: Evidence for Maturation of Positive Feedback in the Male

Gonadotropin and Testosterone Measurements after Estrogen Administration to Adult Men, Prepubertal and Pubertal Boys, and Men with Hypogonadotropism: Evidence for Maturation of Positive Feedback in the Male

The Effects of Cocaine on Gonadal Steroid Hormones and LH in Male and Female Rhesus Monkeys

Pituitary Responsiveness to LH-RH in Post-partum Ewes Treated With Oestradiol-17ß and Failing to Show a Plasma LH Surge

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