Estrogen-induced relaxation of the rat tail artery is attenuated in rats with pulmonary hypertension

Kocić, Ivan; Szczepańska, Renata; Wapniarska, Iga

doi:10.1016/s1734-1140(10)70246-2

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…The cause of this gender discrepancy may be associated with the protective effects of estrogen in females, as well as the potential for males to experience a greater enlargement of the right ventricle during the development of PAH. This is consistent with previously published data on the strong cardioprotective effects of estrogen in different clinical situations [26,38].…”

Section: Discussionsupporting

confidence: 93%

“…Additionally, the contractility of the right ventricle and the reaction to a catecholamine (noradrenaline) was preserved and restored to the normal, control level. We used a well-established model of PAH induced by monocrotaline (MCT) in rats [26]. MCT is a macrocyclic pyrrolizidine alkaloid obtained from seeds of a Crotalaria spectabilis plant.…”

Section: Discussionmentioning

confidence: 99%

“…We used a well-established model of PAH induced by monocrotaline (MCT) in rats [ 26 ]. MCT is a macrocyclic pyrrolizidine alkaloid obtained from seeds of a Crotalaria spectabilis plant.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of nicotinamide and l-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence

Sztormowska-Achranowicz

Jankowski

Kocić

2020

Pharmacol. Rep

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Background The purpose of this paper was to examine the effects of nicotinamide (ND) and l-arginine (l-ARG) on pulmonary vascular and heart changes induced by pulmonary hypertension in rats in a gender-dependent way. Methods Experiments were performed on male (M) and female (F) rats. PAH was induced via monocrotaline injection (sc, 60/kg B.W.) on day one of the 23-day observational period. After that, the animals were sacrificed, hearts removed and weighed and the papillary muscles isolated to measure force of contraction (Fc). Morphological changes of pulmonary vessels were also examined. Results Mixed diet supplementation with l-ARG + ND prevented highly significant right ventricle enlargement induced by PAH in both, male and female rats. Weight ratios between the right ventricle (RV) on one side and the left ventricle with septum on the other (LV + S) decreased from 0.46 ± 0.016 g to 0.29 ± 0.006 g in males and from 0.63 ± 0.03 g to 0.24 ± 0.008 g in females, n = 6, p < 0.001. Additionally, PAH increased basal contractility in female groups, and each of the diet allocations (l-ARG, ND, and mixed) were found to restore contractility to control values. All diet protocols in male and female restored decreased responsiveness of the myocardium to norepinephrine in hearts obtained from rats with PAH and prevented vascular changes observed in pulmonary hypertension (thickness of blood vessels and cell infiltration). Conclusion Our study suggests that l-arginine, nicotinamide or both play a positive role in right ventricle function or the process reducing pulmonary vascular remodeling especially in a gender-independent way.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Protective effect of nicotinamide and l-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence

Sztormowska-Achranowicz

Jankowski

Kocić

2020

Pharmacol. Rep

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“…However, these steroids can also relax arterial smooth muscle via endothelium-independent mechanisms, mainly involving modulation of membrane ionic flux [10,11] . This direct vasodilator effect of PRG and βES has been observed in different arteries from different species such as aorta [12,13] , coronary arteries [8,10,14] , cerebral arteries [15] , omental artery [16] , tail artery [17] and mesenteric artery [9,18,19] . The inhibition of Ca 2+ channels and the activation of K + channels was suggested as a leading cause of the sex horNon-genomic vasorelaxant effects of 17β-estradiol and progesterone on rat aorta are mediated by Ltype Ca…”

Section: Introductionmentioning

confidence: 79%

Non-genomic vasorelaxant effects of 17β-estradiol and progesterone in rat aorta are mediated by L-type Ca2+ current inhibition

et al. 2012

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“…The dosages were chosen according to recent studies on rodents (Lund et al 2005). Assuming an even distribution of β-oestradiol due to its chemical nature, the doses we used yield concentrations of 0.1 to 1 μM and therefore are on the lower end of the scale of doses used for in vivo testing (Lund et al 2005; Rocha et al 2005; Kocic et al 2010; Intapad et al 2011). This is in line with our intention to simulate the rising period of oestrogen and we assume mainly oestrogen receptor mediated effects.…”

Section: Methodsmentioning

confidence: 99%

Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol

2011

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RationaleThe influence of ovarian hormones on behaviour is well accepted, and oestrogen replacement therapy has proven to be beneficial in several cases of menopausal mood disorders. However, there are also some adverse effects of such a therapy, like anxiety and dysphoria. In fact, some women feel better at low levels of oestrogen and worse when levels fluctuate. Still, it is unclear which receptors might mediate negative emotional effects.ObjectivesThe aim of this study was to identify which oestrogen receptor(s) are capable of mediating negative emotional effects and, therefore, may represent candidates responsible for the adverse side effects observed in oestrogen replacement therapy.ResultsWe provide evidence from mouse behavioural tests that oestrogen-induced anxiogenic-like effects might be mediated, at least in part, by the G protein-coupled receptor GPR30. The short-term application of specific agonists against the alpha and beta oestrogen receptors did not result in marked behavioural changes. In contrast, the specific stimulation of GPR30 in male and ovariectomized female mice induced anxiogenic effects. The anxiogenic effects induced by the specific GPR30 agonist G-1 were comparable (and non-accumulative) to those observed after low doses of the general oestrogen receptor agonist 17b-oestradiol in male mice, thereby reflecting the behavioural changes observed in intact female mice during early pro-oestrus.ConclusionsOur data suggest that GPR30 induces acute anxiogenic effects of oestrogen in rodents. It is tempting to speculate that a potential imbalance in the expression of the anxiolytic beta oestrogen receptor and the anxiogenic GPR30 may also be involved in the negative symptoms of oestrogen replacement therapy in humans.

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Estrogen-induced relaxation of the rat tail artery is attenuated in rats with pulmonary hypertension

Cited by 6 publications

References 17 publications

Protective effect of nicotinamide and l-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence

Protective effect of nicotinamide and l-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence

Non-genomic vasorelaxant effects of 17β-estradiol and progesterone in rat aorta are mediated by L-type Ca2+ current inhibition

Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol

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