Estrogen effects on object memory and cholinergic receptors in young and old female mice

Vaucher, Elvire; Reymond, Isabelle; Najaffe, Robert; Kar, Satyabrata; Quirion, Rémi; Miller, M.M.; Franklin, Keith B.J.

doi:10.1016/s0197-4580(01)00250-0

Cited by 87 publications

(70 citation statements)

References 40 publications

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“…It is also consistent with a report in young female mice in which pre-training estradiol treatment improved object recognition (Vaucher et al, 2002). Interestingly, the Enriched-E 2 group did not exhibit a preference for the novel object at the 48-hr delay, suggesting that enrichment reduces the estradiol-induced enhancement of object recognition seen in standardhoused females.…”

Section: Young Femalessupporting

confidence: 91%

“…Indeed, the loss of estrous cycling in middle-age has been associated with the onset of spatial memory decline studies in female rats (Markowska, 1999) and mice (Frick, Burlingame, Arters & Berger-Sweeney, 2000). Accordingly, chronic estrogen treatment administered prior to training can improve various types of learning and memory in middleaged (Daniel, Hulst & Berbling, 2006;Foster, Sharrow, Kumar & Masse, 2003;Markham, Pych & Juraska, 2002) and aged (Frick, Fernandez & Bulinski, 2002;Gibbs, 2000;Heikkinen et al, 2002;Markowska & Savonenko, 2002;Vaucher, Reymond, Najaffe, Kar, Quirion, Miller & Franklin, 2002) female rodents.…”

Section: Introductionmentioning

confidence: 99%

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Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

Gresack

Kerr

Frick

2007

Neurobiology of Learning and Memory

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The present study was designed to examine whether life-long exposure to standard or enriched housing affects the ability of estrogen to improve spatial and object memory throughout the lifespan. Three week-old female mice were maintained in standard or enriched housing up to and through ovariectomy and behavioral testing at 5, 17, or 22 months of age. Spatial memory was tested in the Morris water maze and object memory was tested using an object recognition task. Immediately after training each day, mice were injected intraperitoneally with vehicle or 0.2 mg/kg 17β-estradiol. Among young females, object recognition was enhanced by estradiol alone, an effect that was reduced by enrichment. In contrast, spatial water maze performance was impaired by estradiol alone, but improved by the combination of both estradiol and enrichment. At middle-age, object recognition was enhanced by estradiol or enrichment alone, and the combination of both treatments. Spatial memory in the water maze was also improved by both treatments at middle-age, but the beneficial effects of estradiol were limited to standard-housed females. Finally, whereas enrichment in aged females significantly enhanced performance in both tasks, estradiol had no effect at this age in either task. In total, the data indicate that life-long enrichment can significantly alter the extent to which estradiol affects memory in mice throughout the lifespan. Importantly, the interaction between these treatments is highly dependent on age and type of memory tested.

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Section: Young Femalessupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

Gresack

Kerr

Frick

2007

Neurobiology of Learning and Memory

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“…This finding is similar to previous estrogeninduced improvements in these tasks (Bimonte and Denenberg, 1999;Vaucher et al, 2002). However, these studies differ in that the present study administered estrogen post-training rather than prior to training.…”

Section: Effects Of Estrogen In Sc-housed Micesupporting

confidence: 90%

“…Frick et al, 2002;Gibbs, 2000;Luine and Rodriguez, 1994;Vaucher et al, 2002; although see Chesler and Juraska, 2000;Fugger et al, 1998;Holmes et al, 2002). However, because studies such as these administer estrogen prior to training, they cannot distinguish between the effects of estrogen on mnemonic processes versus the effects on other performance factors present during training.…”

mentioning

confidence: 99%

Environmental enrichment reduces the mnemonic and neural benefits of estrogen

Gresack

Frick

2004

Neuroscience

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The degree to which memory is enhanced by estrogen replacement in postmenopausal women may depend on environmental factors such as education. The present study utilized an animal model of environmental enrichment to determine whether environmental factors influence the mnemonic and neural response to estrogen. Female mice were raised in standard (SC) or enriched (EC) conditions from weaning until adulthood (7 months). All mice were ovariectomized at 10 weeks, and tested in object recognition and water-escape motivated radial arm maze (WRAM) tasks at 6 months. Each day at the completion of training, mice received injections of 0.1 mg/kg cyclodextrin-encapsulated

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“…In general, this decline occurs earlier in female (~17 months), as compared to male (~24 months), mice and among females decline seems to coincide with cessation of ovarian function [24,51,60,61]. Second, E 2 to senescent female or male rats improves spatial performance [32,48] and E 2 to aged female mice enhances spatial and non-spatial performance [23,25,53,91]. However, whether the aforementioned effects of E 2 were attributable to mnemonic-or performance-enhancing effects of E 2 was not dissociated because E 2 was present during training and testing.…”

Section: Introductionmentioning

confidence: 95%

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

2005

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Although 17β-Estradiol (E 2 ) improves cognitive performance of aged female mice, its mnemonic effects when administered post-training to aged male mice have not been examined. E 2 (10 µg, SC) or oil vehicle was administered to intact, 24-month-old female or male congenic (primarily C57BL/6 background) mice immediately after training in the inhibitory avoidance or water maze tasks. Following behavioral testing, effects of 1 or 24 h of E 2 exposure on hippocampal levels of E 2 and brain-derived neurotrophic factor (BDNF) were examined. Female and male mice administered E 2 showed significantly better performance in the inhibitory avoidance task than did vehicle-administered mice. When tested 24 h after training, mice that received E 2 had significantly longer latencies to cross-over to the shock-associated side of the chamber than did vehicleadministered mice. Female or male mice administered E 2 showed significantly better performance in the reference memory aspect of the spatial water maze task. When tested 30 min after training, mice administered E 2 had shorter latencies to, and spent longer swimming in, the quadrant that the hidden platform had previously been located in. E 2 administration produced physiological levels of E 2 in the hippocampus 1 and 24 h after E 2 . BDNF levels in the hippocampus were decreased following 1 h of E 2 exposure compared to vehicle. These findings suggest that E 2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task.

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Estrogen effects on object memory and cholinergic receptors in young and old female mice

Cited by 87 publications

References 40 publications

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

Environmental enrichment reduces the mnemonic and neural benefits of estrogen

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

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