Environmental enrichment reduces the mnemonic and neural benefits of estrogen

Gresack, Jodi; Frick, Karyn M.

doi:10.1016/j.neuroscience.2004.06.011

Cited by 71 publications

(91 citation statements)

References 95 publications

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“…The present study replicates our previous reports demonstrating that posttraining 0.2 mg/kg 17β-estradiol enhances object memory tested 48 hours after the sample phase (Gresack & Frick, 2004, 2006, and extends this work to show that this enhancement involves the activation of NMDA receptors and PKA within the dorsal hippocampus. To our knowledge, this is the first evidence that estradiol-induced enhancement of memory consolidation involves these pathways.…”

Section: Discussionsupporting

confidence: 92%

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.

Lewis¹,

Kerr²,

Orr³

et al. 2008

Behavioral Neuroscience

136

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This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17β-estradiol (E 2 )-induced enhancement of object memory consolidation. Mice explored two identical objects during training, after which they immediately received intraperitoneal injections of 0.2 mg/ kg E 2 , and bilateral dorsal hippocampal infusions of Vehicle, the NMDA receptor antagonist APV (2.5 μg/side), or the cAMP inhibitor Rp-cAMPS (18.0 μg/side). Retention was tested 48 hours later. The enhanced object memory and increased ERK phosphorylation observed with E 2 alone was reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA receptors and PKA activation within the dorsal hippocampus.

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Section: Discussionsupporting

confidence: 92%

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.

Lewis¹,

Kerr²,

Orr³

et al. 2008

Behavioral Neuroscience

136

View full text Add to dashboard Cite

show abstract

“…Perhaps our handling procedure may have negated estrogen's effects on the Y-maze because of the enriched setting. Environmental enrichment can increase spatial memory ability on several tasks (Fernandez-Teruel et al, 1997;Gresack and Frick, 2004). However, a recent finding demonstrated that while mice treated with estrogen had improved spatial memory, estrogen combined with previous exposure to an enriched environment did not alter object recognition and actually impaired work memory acquisition (Gresack and Frick, 2004).…”

Section: The Lack Of An Estrogen Influence On Hippocampal Morphology mentioning

confidence: 99%

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

et al. 2005

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Emerging data report sex differences in how the brain responds to chronic stress. Here, we investigated the effects of chronic restraint stress (6 h/day/21 days) on hippocampal morphology and function in ovariectomized female rats. Chronic restraint stress caused CA3 apical dendritic retraction in short-and long-shafted neurons, while it reduced basal dendritic arbors in long-shafted neurons only. Chronic restraint did not affect CA1 dendritic arborization, although it increased the proportion of CA1 spine heads compared with controls. Both stressed and control animals performed well on the Y-maze, a spatial memory task. However, chronic stress enhanced Y-maze performance compared with controls, which may reflect facilitated spatial memory or reduced habituation. Ymaze performance correlated with CA1 spine head proportion. This relationship suggests that spatial ability in females may be more tightly coupled with CA1 morphology, which may override the influence of CA3 dendritic retraction. Thus, this research provides additional evidence that CA3 morphology does not always parallel spatial memory.

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“…Estrogen is thought to be beneficial for memory because it enhances the structure and function of mnemonic brain regions such as the hippocampus that deteriorate in normal aging and Alzheimer's disease (Foy, Xu, Xie, Brinton, Thompson & Berger, 1999;Warren, Humphreys, Juraska & Greenough, 1995;Woolley & McEwen, 1992, and because hippocampal-dependent memory (e.g., spatial memory, object recognition) is typically improved by exogenous estrogen administration in young ovariectomized female rats (Bimonte & Denenberg, 1999;Daniel, Fader, Spencer & Dohanich, 1997;Gibbs, 1999;O'Neal, Means, Poole & Hamm, 1996;Sandstrom & Williams, 2001) and mice (Gresack & Frick, 2004, 2006bHeikkinen, Puoliväli, Liu, Rissanen & Tanila, 2002;Rissanen, Puoliväli, van Groen & Riekkinen, 1999). Estrogen is also a trophic factor for the adult hippocampus (Brinton, 2001), and therefore, estrogen deficiency during aging may render the hippocampus more vulnerable to deterioration and exacerbate emerging age-related memory deficits.…”

Section: Introductionmentioning

confidence: 99%

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

Gresack

Kerr

Frick

2007

Neurobiology of Learning and Memory

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The present study was designed to examine whether life-long exposure to standard or enriched housing affects the ability of estrogen to improve spatial and object memory throughout the lifespan. Three week-old female mice were maintained in standard or enriched housing up to and through ovariectomy and behavioral testing at 5, 17, or 22 months of age. Spatial memory was tested in the Morris water maze and object memory was tested using an object recognition task. Immediately after training each day, mice were injected intraperitoneally with vehicle or 0.2 mg/kg 17β-estradiol. Among young females, object recognition was enhanced by estradiol alone, an effect that was reduced by enrichment. In contrast, spatial water maze performance was impaired by estradiol alone, but improved by the combination of both estradiol and enrichment. At middle-age, object recognition was enhanced by estradiol or enrichment alone, and the combination of both treatments. Spatial memory in the water maze was also improved by both treatments at middle-age, but the beneficial effects of estradiol were limited to standard-housed females. Finally, whereas enrichment in aged females significantly enhanced performance in both tasks, estradiol had no effect at this age in either task. In total, the data indicate that life-long enrichment can significantly alter the extent to which estradiol affects memory in mice throughout the lifespan. Importantly, the interaction between these treatments is highly dependent on age and type of memory tested.

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Environmental enrichment reduces the mnemonic and neural benefits of estrogen

Cited by 71 publications

References 95 publications

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

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