Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation

Lagattuta, Kaitlyn A.; Nigrović, Peter A.

doi:10.1007/978-3-030-76912-3_11

Cited by 7 publications

(7 citation statements)

References 122 publications

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“…The total Fc glycan profile in pregnant women, which included fucosylation and sialylation, was oriented toward reduced inflammation (Alter et al, 2018;Lagattuta and Nigrovic, 2021). In contrast, the total Fab glycans, which involved increased fucosylation, agalactosylation, and bisection, had been associated with increased inflammation (Alter et al, 2018;Lagattuta and Nigrovic, 2021). Non-inflammatory Fc galactosylation and sialylation as well as Fab N-acetylglucosamine bisection of bulk antibodies during pregnancy have been reported elsewhere (Bondt et al, 2014(Bondt et al, , 2016Jansen et al, 2016;Ruhaak et al, 2014;Van De et al, 2009;Selman et al, 2012).…”

Section: Multivariate Signatures Of Antibodies During Pregnancymentioning

confidence: 98%

“…Vastly different glycosylation of total and influenza-specific antibodies was observed in pregnant women compared to non-pregnant controls. The total Fc glycan profile in pregnant women, which included fucosylation and sialylation, was oriented toward reduced inflammation (Alter et al, 2018;Lagattuta and Nigrovic, 2021). In contrast, the total Fab glycans, which involved increased fucosylation, agalactosylation, and bisection, had been associated with increased inflammation (Alter et al, 2018;Lagattuta and Nigrovic, 2021).…”

Section: Multivariate Signatures Of Antibodies During Pregnancymentioning

confidence: 99%

“…In addition, antibodies produced during pregnancy display unique glycosylation patterns (Bondt et al, 2013(Bondt et al, , 2014Einarsdottir et al, 2013). Collectively, these changes favor a non-inflammatory and tolerogenic environment (Alter et al, 2018;Lagattuta and Nigrovic, 2021). As a result, autoimmune conditions, such as rheumatoid arthritis, may transiently resolve during pregnancy (Fo ¨rger and Fo ¨rger, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional and structural modifications of influenza antibodies during pregnancy

et al. 2022

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Section: Multivariate Signatures Of Antibodies During Pregnancymentioning

confidence: 98%

Section: Multivariate Signatures Of Antibodies During Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional and structural modifications of influenza antibodies during pregnancy

et al. 2022

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“… 81 , 82 ). These findings may provide a mechanistic explanation for the elevation of the risk of rheumatic disease among menopausal women, and possibly define a pathway by which age and sex modulate immunity 83 . However, even with these important insights into the regulation of antibody Fc glycosylation, the precise pathways regulating N-glycosylation of IgG in health and disease remain largely unexplored, and further studies are needed to improve our understanding of how glycosylation changes occur and whether they are relevant to the disease course.…”

Section: Glycosylation Of Proteinsmentioning

confidence: 81%

Glycobiology of rheumatic diseases

et al. 2022

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Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor interactions and signal transduction. In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes and disease progression. For example, the Fc-glycan composition on (auto)antibodies is associated with disease activity, and the presence of additional glycans in the antigen-binding domains of some autoreactive B cell receptors can affect B cell activation. In addition, changes in synovial fibroblast cell-surface glycosylation can alter the synovial microenvironment and are associated with an altered inflammatory state and disease activity in rheumatoid arthritis. The development of our understanding of the role of glycosylation of plasma proteins (particularly (auto)antibodies), cells and tissues in rheumatic pathological conditions suggests that glycosylation-based interventions could be used in the treatment of these diseases.

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“…Because previous studies in the general population indicated that menopause and sex hormones have an impact on IgG glycosylation, 33–36 we performed a secondary analysis of the women samples based on self-reported menopause status: pre-menopause (n=60 HIV-negative and n=35 WWH), peri-menopause (n=21 HIV-negative and n=20 WWH), or post-menopause (n=152 HIV-negative and n=198 WWH). We compared the IgG glycomic groups ( Supplementary Figure 2 ) or individual glycan traits ( Supplementary Table 1 ) among these menopause groups.…”

Section: Resultsmentioning

confidence: 99%

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

Giron

Liu

Adeniji

et al. 2023

Preprint

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People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute to or are associated with this vulnerability remain uncertain. In the general population, alterations in the glycomes of circulating IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG glycomes of cross-sectional and longitudinal samples from 1216 women and men, living with virally-suppressed HIV or without HIV. Our glycan-based machine learning models indicate that chronic HIV infection accelerates the accumulation of pro-aging-associated glycomic alterations by an average of 3 years in women and 3.5 years in men. Consistently, PWH exhibit heightened expression of senescence-associated glycan-degrading enzymes compared to their controls. HIV/ART-mediated glycomic alterations correlate with elevated markers of inflammatory aging and the severity of comorbidities, may precede the development of such comorbidities, and are linked to compromised anti-viral IgG-mediated innate immune functions. These findings hold significant potential for the development of glycomic-based biomarkers and tools to identify and prevent premature aging and comorbidities in people living with chronic viral infections.

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Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation

Cited by 7 publications

References 122 publications

Functional and structural modifications of influenza antibodies during pregnancy

Functional and structural modifications of influenza antibodies during pregnancy

Glycobiology of rheumatic diseases

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

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