Estrogen and Progesterone Receptors in Melanocytic Lesions

Ellis, Darrel L.

doi:10.1001/archderm.1985.01660100062015

Cited by 28 publications

(8 citation statements)

References 29 publications

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“…In particular, breast nevi showed more tendency to have intraepidermal melanocytes above the basal layer, atypical cytologic features, and papillary fibroplasia. These differences could be ascribed to the estrogenic influences which, while exerting an important influence on breast tissue, play also a role in melanocytic proliferation 6 . However, our data did not confirm such a hypothesis, as we did not find any sexual difference and were also unable to confirm in the breast area the increased prevalence of papillomatous melanocytic nevi that have been claimed to depend on estrogenic influence 7 …”

Section: Discussioncontrasting

confidence: 74%

Melanocytic nevi of the breast: a histologic case‐control study

et al. 2003

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Section: Discussioncontrasting

confidence: 74%

Melanocytic nevi of the breast: a histologic case‐control study

et al. 2003

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“…Although many researchers have shown the ability of melanocyte to bind to the hormones, such as estrogen and progesterone, using a hormone-binding assay, true hormone receptors have not been molecularly identified in human melanocytes (5,6).…”

Section: Introductionmentioning

confidence: 99%

Donor Specific Response of Estrogen and Progesterone on Cultured Human Melanocytes

Lee

Kim

et al. 2002

J Korean Med Sci

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The mechanisms of estrogen and progesterone in human cutaneous pigmentation are largely unknown. The molecular identification of estrogen receptor (ER) and progesterone receptor (PR) in the human melanocytes is of great importance to understand the mechanisms. We performed immunocytochemistry analysis and demonstrated that ER and PR were expressed in the cytoplasms and nuclei of human melanocytes. Reverse transcriptase-polymerase chain reaction (RT-PCR) and sequence analysis confirmed the expression of ER and PR at the transcriptional level. Despite of the presence of ER and PR, the physiological and pregnant levels of estrogen and progesterone showed inconsistent effects on the proliferation and tyrosinase activity of cultured human melanocytes. These results suggest that human melanocytes express ER and PR, which have a donorspecific action in human pigmentation. Further studies are needed to elucidate the induction mechanism and functions of these receptors, and the role of estrogen and progesterone in melanocytes.

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“…In this particular anatomical setting these features are frequently described together with occasional intraepidermal melanocytes above the basal layer. All these features may be related to estrogenic stimulation, 3 and should not lead to an overdiagnosis of melanoma. 4 The histological diameter of this melanocytic lesion was 2 mm and contrasted with its clinical appearance which was of a broader and irregular macule 7 mm wide.…”

Section: Discussionmentioning

confidence: 99%