Melanocytic nevi of the breast: a histologic case‐control study

Rongioletti, Franco; Urso, Carmelo; Batolo, D; Chimenti, Sergio; Fanti, Pier ­Alessandro; Filotico, Raffaele; Gianotti, Raffaele; Innocenzi, D.; Lentini, Maria; Tomasini, Carlo Francesco; Pippione, M; Rebora, Alfredo

doi:10.1111/j.0303-6987.2004.00159.x

Cited by 53 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, there was no gender difference. 59 Whether this represents a finding related to site of occurrence of entirely banal nevi (as with genital nevi), or a proclivity for nevi with dysplastic features to favor breast skin is yet to be resolved. There is no doubt that authentic dysplastic nevi may also occur, perhaps preferentially, on the skin of the breast (Figure 3).…”

Section: Nevi Of the Breastmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

View full text Add to dashboard Cite

Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma.

show abstract

Section: Nevi Of the Breastmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

View full text Add to dashboard Cite

show abstract

“…In a recent study, 101 naevi from the breast were compared histologically with 97 naevi from other anatomic locations matched for age and sex. 23 Breast naevi demonstrated significantly more atypical features than the controls and tended to specifically show more prominent intraepidermal melanocytes above the basal layer, melanocytic atypia, and dermal fibroplasia. Asymmetry, poor circumscription, lentiginous growth, dyshesive nested pattern, involvement of adnexa, and presence of inflammation did not differ from naevi of other sites.…”

Section: Naevi Of Acral Skinmentioning

confidence: 89%

“…Naevi of the breast Recently, there have been observations of particular atypical features in naevi of the breast. 4,5,23 These lesions may occur in various locations about the chest and including the milk line. They may involve the nipple areolar complex or the skin in more peripheral locations.…”

Section: Naevi Of Acral Skinmentioning

confidence: 99%

Melanocytic naevi of special sites

Cook

2010

Diagnostic Histopathology

View full text Add to dashboard Cite

“…There is little to suggest that stable moles in these special sites progress to melanoma or are markers for increased melanoma risk. [35][36][37][38][39][40][41][42][43][44] OPTIMAL BIOPSY TECHNIQUE Atypical/dysplastic nevi with no features suspicious for melanoma do not require biopsy. In contrast, any lesion suspicious for malignant melanoma must be removed, and it is reasonable to remove ''ugly ducklings'' (lesions that differ from the patient's signature pattern of moles).…”

Section: Are Atypical/dysplastic Nevi Precursors For Melanoma?mentioning

confidence: 99%