Estradiol and Progesterone Endometrial Receptors and Body Fat Distribution in Obese Women

Morán, Carlos; García-Hernández, E; Cortés, Marco A.; Calzada, L; Salazar, Lucía; Bermúdez, José

doi:10.1159/000291916

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Particularly relevant to estrogen-sensitive cancers, leptin has been shown to amplify estrogen signaling by either increasing aromatase expression in stromal and cancer cells (10, 11) or by activating ERα through ERK and STAT3 signaling pathways (12–14), establishing a functional crosstalk between leptin and estrogen signaling pathways. The leptin-estrogen connection is further supported by studies showing that obesity is associated with an increase in systemic estrogen levels (15, 16) and that obese women exhibit higher levels of ERα expression than lean women in several types of cancers (17). …”

Section: Introductionmentioning

confidence: 90%

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA

et al. 2014

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Obesity is a pandemic and major risk factor for cancers. The reduction of obesity would have been an effective strategy for cancer prevention, but the reality is that worldwide obesity has kept increasing for decades, remaining a major avoidable cancer risk secondary only to smoke. The present studies suggest that vitamin D may be an effective agent to reduce obesity-associated cancer risks in women. Molecular analyses showed that leptin increased human telomerase reverse transcriptase (hTERT) mRNA expression and cell growth through estrogen receptor alpha (ERα) activation in ovarian cancer (OCa) cells, which was suppressed by 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. The suppression was compromised when miR-498 induction by the hormone was depleted with miRNA sponges. In mice, high-fat diet (HFD) stimulation of ovarian tumor growth was remarkably suppressed by 1,25(OH)2D3 analogue EB1089, which was also compromised by miR-498 sponges. EB1089 did not alter HFD-induced increase in serum leptin levels but increased miR-498 and decreased the diet-induced hTERT expression in tumors. Quantitative RT-PCR (qRT-PCR) analyses revealed an inverse correlation between hTERT mRNA and miR-498 in response to 1,25(OH)2D3 in estrogen-sensitive ovarian, endometrial and breast cancers. The studies suggest that miR-498-mediated hTERT down regulation is a key event mediating the anti-leptin activity of 1,25(OH)2D3 in estrogen-sensitive tumors in women.

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Section: Introductionmentioning

confidence: 90%

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA

et al. 2014

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“…In a study conducted on university students, it is stated that the overweight and obesity values determined by BMI values are below the values seen in the advanced age groups in our country's national studies, indicating an increase in the prevalence of obesity due to advancing age (Bektaş et al, 2014). It should also be taken into account that the biological composition of women (such as the hormone estrogen) increases fat storage (Bektaş et al, 2014;Moran et al, 1996). Although this information shows that the result of this study can be considered normal, it rather supports Solmaz and Akbulut (2018) that not gaining more than 10 kg after 18-20 years of age will not create any increase in cardiovascular health risk.…”

Section: Discussion and Resultsmentioning

confidence: 52%

An Investigation into the Body Mass Index Levels of Female University Students and Women from Different Ages

Güler

2021

JEI

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The purpose of this study was to determine and to evaluate the Body Mass Index (BMI) levels of female students between the ages of 20 and 30 who study at Amasya University and women between the ages of 40 and 60 who live in Amasya since BMI levels are of great importance to determine the body fat levels for a healthy body. We recruited 910 female students and 688 women. All participants had no health problems. The formula we used for BMI levels of the participants was BMI = kg/m2. We relied on such parameters as mean, standart deviation, minimum and maximum values for statistical analyses of the data. We conducted the independent samples t test to see if there was any statistically significant differences between groups. The findings showed that female university students’ body mass index levels were 21.84 kg/m2, while women living in Amasya had 27.68 kg/m2 body mass index levels. We found a statistically significant difference in the body mass index levels between the groups in favor of the female university students. We conclude that female university students between the ages of 20 and 30 who study at Amasya University had normal levels of BMI when compared with women between the ages of 40 and 60 who live in Amasya.

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