Estimation of the Solubility of Sulfonamides in Aqueous Media from Partition Coefficients and Entropies of Fusion

Determination and Temperature Dependence of n-Octanol/Water Partition Coefficients for Seven Sulfonamides from (298.15 to 333.15) K

“…The result showed that the deviations of the measured noctanol/water partition coefficient from the literature values 11,12 are less than 2%. In this work, the uncertainty of the logarithm for experimental n-octanol/water partition coefficient was estimated to be less than 0.0005.…”

“…11,12 The n-octanol/water partition coefficient is defined as (1) where P ow is the n-octanol/water partition coefficient of sulfonamide, c o is the concentration of the sulfonamide in the n-octanol phase at equilibrium, c w is the concentration of the sulfonamide in the aqueous phase at equilibrium. P ow is actually the phase equilibrium constant for sulfonamide partitioned in the n-octanol phase and the aqueous phase saturated with each other at some temperature.…”

Aplicación del Método Extendido de Hildebrand a la solubilidad de la mitomicina C en mezclas etanol + agua

“…(5) where, the W term is equal to 2Kδ 1 δ 3 (where, K is the Walker parameter (Martínez and Gómez, 2002). The W factor can be calculated from experimental data by means of, (6) where, γ 3 is the activity coefficient of the solute in the saturated solution, and it is calculated as, .…”

“…It is noteworthy that cosolvency is the best technique used in pharmacy for increasing drugs solubility (Rubino, 1988;Yalkowsky, 1999). On the other hand, it is clear that predictive methods of physicochemical properties of drugs, in particular the ones intended to estimate solubilities, are very important for industrial pharmacists because they allow optimizing several design processes (Budavari, 2001;Martin, et al, 1993;Regosz, et al, 1992;Martínez and Gómez, 2002;Hanaee, et al, 2005).…”

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of <i>N</i>-(Alkyl/aralkyl)-<i>N</i>-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

“…1 Sulfa drugs do not possess any odor and they are mostly white in color or have slightly colored solids, soluble in water and exhibits more than two polymorphic forms. 2,3,4 Sulfonamides are capable of inhibiting bacterial growth, they also contest against p-aminobenzoic acid for dihydropteroatesynthetase enzyme, which is necessary for the biogenesis of folic acid (required for the growth of cell) by bacteria. 5,6 Sulfonamides possess antimicrobial activity against Gram-positive and Gramnegative bacteria and act as carbonic anhydrase inhibitors.…”