Estimation of the potential overall impact of human papillomavirus vaccination on cervical cancer cases and deaths

Kriekinge, Georges Van; Castellsagué, Xavier; Cibula, David; Demarteau, Nadia

doi:10.1016/j.vaccine.2013.11.049

Cited by 50 publications

(30 citation statements)

References 20 publications

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“…However, the impact of this strategy on mortality rates will be observed only in the future, and its effectiveness depends on the coverage of these vaccines in the target population [8]. …”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

Almeida

Martins

Pontes

et al. 2017

Journal of Environmental and Public Health

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To evaluate the impact of HPV immunization and possible changes in virus type-specific prevalence associated with cervical cancer, it is important to obtain baseline information based on socioeconomic, educational, and environmental characteristics in human populations. We describe these characteristics and the type-specific HPV distribution in 1,183 women diagnosed with cervical cancer in two Brazilian healthcare institutions located at the Southeastern (Rio de Janeiro/RJ) and the Amazonian (Belém/PA) regions. Large differences were observed between women in these regions regarding economic, educational, and reproductive characteristics. The eight most frequent HPV types found in tumor samples were the following: 16, 18, 31, 33, 35, 45, 52, and 58. Some HPV types classified as unknown or low risk were found in tumor samples with single infections, HPV 83 in RJ and HPV 11, 61, and 69 in PA. The proportion of squamous cervical cancer was lower in RJ than in PA (76.3% versus 87.3%, p < 0.001). Adenocarcinoma was more frequent in RJ than in PA (13.5% versus 6.9%, p < 0.001). The frequency of HPV 16 in PA was higher in younger women (p < 0.05). The success of a cervical cancer control program should consider HPV types, local health system organization, and sociodemographic diversity of Brazilian regions.

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“…However, the impact of this strategy on mortality rates will be observed only in the future, and its effectiveness depends on the coverage of these vaccines in the target population [8]. …”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

Almeida

Martins

Pontes

et al. 2017

Journal of Environmental and Public Health

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“…It is now widely accepted that HPV vaccination offers tremendous potential for prevention of HPV-related pre-cancers and cancers and could substantially reduce cervical cancer mortality [31]. The U.S.…”

Section: Introductionmentioning

confidence: 99%

Differences in Human Papillomavirus Vaccination Among Adolescent Girls in Metropolitan Versus Non-metropolitan Areas: Considering the Moderating Roles of Maternal Socioeconomic Status and Health Care Access

Monnat

Rhubart

Wallington

2015

Matern Child Health J

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Objectives This study is among the first to examine metropolitan status differences in human papillomavirus (HPV) vaccine initiation and completion among United States adolescent girls and is unique in its focus on how maternal socioeconomic status and health care access moderate metropolitan status differences in HPV vaccination. Methods Using cross-sectional data from 3573 girls aged 12–17 in the U.S. from the 2008–2010 Behavioral Risk Factor Surveillance System, we estimate main and interaction effects from binary logistic regression models to identify subgroups of girls for which there are metropolitan versus non-metropolitan differences in HPV vaccination. Results Overall 34 % of girls initiated vaccination, and 19 % completed all three shots. On average, there were no metropolitan status differences in vaccination odds. However, there were important subgroup differences. Among low-income girls and girls whose mothers did not complete high school, those in non-metropolitan areas had significantly higher probability of vaccine initiation than those in metropolitan areas. Among high-income girls and girls whose mothers completed college, those in metropolitan areas had significantly higher odds of vaccine initiation than those in non-metropolitan areas. Moreover, among girls whose mothers experienced a medical cost barrier, non-metropolitan girls were less likely to initiate vaccination compared to metropolitan girls. Conclusions Mothers remain essential targets for public health efforts to increase HPV vaccination and combat cervical cancer. Public health experts who study barriers to HPV vaccination and physicians who come into contact with mothers should be aware of group-specific barriers to vaccination and employ more tailored efforts to increase vaccination.

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“…These vaccines are given preferably to young girls at the approved 3-dose schedule over a 6-month period. This approach has been shown to be a cost-effective strategy in preventing cervical cancer in developed and developing countries 23,20 . These preventive vaccines have been subsidized for use in resourcelimited settings, and a recent modeling of optimal cervical cancer prevention strategies in Nigeria estimated a cost of N7,095 ($45) for the 3 doses of HPV vaccination 24 .…”

Section: Vaccinationmentioning

confidence: 99%

The Need for Societal Investment to Improve Cervical Cancer Outcomes in Nigeria: A commentary

Musa

2017

Afr J Reprod Health

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Although cervical cancer is a preventable cancer with a well-known natural history, it remains a huge burden in developing countries of sub-Saharan Africa where organized cervical cancer screening services are lacking. Developed countries that have invested on providing organized screening programs have made substantial progress in reducing both incidence and mortality due to cervical cancer. Implementing evidence-based interventions such as human papillomavirus (HPV) vaccination of young girls, early detection and treatment of premalignant conditions of the cervix through conventional Pap cytology, HPV screening or visual aided inspection with acetic acid could significantly reduce incidence of new cases at population level. Societal investment for such preventive services and provision of effective treatment for those diagnosed at early stages will yield economic benefits in reducing premature deaths of women at the prime of their productive lives. From a societal perspective, this should be a priority area for national investment towards the achievement of sustainable development in Nigeria and similar settings in Africa. (Afr J Reprod Health 2017; 21[4]: 17-23).Keywords: Cancer prevention, treatment, society, cervical cancer RésuméBien que le cancer du col de l'utérus soit un cancer évitable avec une histoire naturelle bien connue, il reste un lourd fardeau dans les pays en développement d'Afrique subsaharienne où les services organisés de dépistage du cancer du col de l'utérus font défaut. Les pays développés qui ont investi dans la mise en place de programmes de dépistage organisés ont fait des progrès substantiels dans la réduction de l'incidence et de la mortalité dues au cancer du col de l'utérus. La mise en oeuvre d'interventions fondées sur des données probantes comme la vaccination des jeunes filles contre le papillomavirus humain (VPH), la détection précoce et le traitement des pathologies précancéreuses du col utérin par la cytologie des frottis vaginaux conventionnelle, le dépistage du VPH ou l'inspection visuelle assistée par l'acide acétique pourraient réduire de manière significative la fréquence des nouveaux cas au niveau de la population. L'investissement sociétal pour de tels services préventifs et la fourniture d'un traitement efficace aux personnes diagnostiquées à un stade précoce produiront des bénéfices économiques en réduisant les décès prématurés des femmes quand elles sont dans la fleur de leur vie productive. D'un point de vue sociétal, cela devrait constituer un domaine prioritaire pour l'investissement national en vue de la réalisation du développement durable au Nigeria et dans des contextes similaires en Afrique. (Afr J Reprod Health 2017; 21[4]: 17-23).

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Estimation of the potential overall impact of human papillomavirus vaccination on cervical cancer cases and deaths

Abstract: HPV vaccination could reduce the burden of CC and precancerous lesions in countries worldwide, part of disease burden reduction being related to protection against non HPV-16/18 related types.

Cited by 50 publications

References 20 publications

Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

Differences in Human Papillomavirus Vaccination Among Adolescent Girls in Metropolitan Versus Non-metropolitan Areas: Considering the Moderating Roles of Maternal Socioeconomic Status and Health Care Access

The Need for Societal Investment to Improve Cervical Cancer Outcomes in Nigeria: A commentary

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