Estimation of the LDL subclasses in ischemic stroke as a risk factor in a Chinese population

Duan, Rui‐Sheng; Wang, Handong; Wang, Kunpeng; Yin, Nan; Hao, Hongyu; Chu, Hongshan; Wang, Lijun; Meng, Peng; Diao, Le

doi:10.1186/s12883-020-01989-6

Cited by 19 publications

(18 citation statements)

References 25 publications

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“…LDL3 and LDL4 are subtypes with higher concentrations of sdLDL-C. in our research, we also found a signi cant positive correlation between LDL3 and LDL4 levels and the severity of coronary artery stenosis. Our study illustrated that the sdLDL-C level was positively correlated with traditional cardiovascular risk factors, including TC, TG, and LDL-C, which is consistent with the results of a previous study [33]. To identify people at high cardiovascular risk, we constructed a model that included the evaluation of clinical variables in cardiovascular risk factors.…”

Section: Discussionsupporting

confidence: 88%

The Role of Small Dense Low-Density Lipoprotein Cholesterol in the Prediction of Acute Myocardial Infarction

Ma¹,

Liu²,

Huang³

et al. 2021

Preprint

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Background: Acute myocardial infarction (AMI) is a common acute and severe cardiovascular disease. A growing body of evidence suggests that small dense low-density lipoprotein cholesterol (sdLDL-C) is associated with an increased risk of cardiovascular disease. This study aimed to evaluate the predictive value of different lipid indicators, particularly sdLDL-C, in the assessment of AMI.Methods: We retrospectively reviewed the hospital database for all consecutive participants who underwent coronary angiography due to the experience of chest pain in our hospital from September 2019 to June 2020. The basic demographic and clinical data and laboratory assay results for all participants were collected and evaluated at admission. Statistical analysis was performed using SPSS version 26.0.Results: A total of 216 patients with AMI, 154 patients with unstable angina pectoris (UAP) and 103 healthy subjects were included. The levels of LDL3-7 were significantly different among the three groups (P<0.05). Significant positive correlations were observed between the Gensini score and several variables, including hypertension and levels of glucose, sdLDL-C, TC, and LDL-C (r > 0.1, P < 0.001). The sdLDL-C level in the AMI group was significantly higher than that in the control group in individuals with normal LDL-C (P < 0.001). Based on the receiver operating characteristic (ROC) curves, the area under the curve (AUC) of sdLDL-C for AMI risk was 0.666, which was better than that of other lipids. Multivariate logistic regression analysis demonstrated that the sdLDL-C level was significantly correlated with AMI. A logistic regression model were established based on sdLDL-C and other variables to identify people at high cardiovascular risk, with an AUC of 0.868.Conclusions: Increased sdLDL-C level was an independent risk factor for AMI. sdLDL-C may be a useful parameter for the assessment of AMI and help clinicians classify high-risk cardiovascular disease.

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Section: Discussionsupporting

confidence: 88%

The Role of Small Dense Low-Density Lipoprotein Cholesterol in the Prediction of Acute Myocardial Infarction

Ma¹,

Liu²,

Huang³

et al. 2021

Preprint

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“…Foam cells could fuse and burst, releasing large amounts of cholesterol that form the core of atherosclerotic plaque. This process could also aggravate AS and affect the outcomes of stroke (30)(31)(32). Dobiasova et al found that the AIP value was inversely proportional to the diameter of oxidized LDL particles and indirectly showed sdLDL particle size, which could be used as an indirect method to reflect LDL particle size instead (33).…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Index of Plasma Predicts Outcomes in Acute Ischemic Stroke

Liu

Pei

et al. 2021

Front. Neurol.

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Aim: The atherogenic index of plasma (AIP) was significantly related to adverse outcomes in patients with cardiovascular disease. Our aim was to investigate the association between AIP and adverse outcomes in acute ischemic stroke.Methods: Patients with acute ischemic stroke (AIS) admitted between 2015 and 2018 were prospectively enrolled in this study. Functional outcomes were evaluated by the modified Rankin Scale (mRS). Poor outcomes were defined as mRS 3–6. The relationship of AIP with the risk of outcomes was analyzed by multivariate logistic regression models.Results: A total of 1,463 patients with AIS within 24 h of symptom onset were enrolled. The poor outcome group had a significantly higher level of AIP [0.09 (−0.10 to 0.27) vs. 0.04 (−0.09 to 0.18), p < 0.001] compared with the good outcome group. Multivariable logistic regression analysis showed that higher AIP was associated with poor outcomes in all the stroke patients (OR 1.84, 95% CI, 1.23–2.53, p = 0.007), which was more evident in patients with large-artery atherosclerosis subtype (OR 1.90, 95% CI, 1.53–2.62, p = 0.002), but not in the other subtypes. Receiver operating curve (ROC) analysis revealed that the best predictive cutoff value of AIP was 0.112, with a sensitivity of 70.8% and a specificity of 59.2%, and the area under the ROC curves for AIP was 0.685.Conclusion: AIP may be an important and independent predictor of the outcome of dysfunction in patients with AIS, especially the stroke subtype of large-artery atherosclerosis.

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“…In stark contrast, sdLDL has been considered to have more atherogenic effect than other LDL particles due to its increased susceptibility to oxidation, high endothelial permeability, and decreased hepatic LDL receptor affinity [ 36 , 37 ]. Previous studies demonstrate that sdLDL-C is a new risk factor for cardiovascular events [ 11 , 15 , 16 , 38 ]. For instance, one previous study suggested that sdLDL-C concentrations were a better marker for assessment of coronary heart disease (CHD) than total LDL-C [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since evidence showed that patients who took lipid-lowering drugs and reached the set LDL-C level were still at risk of cardiovascular and cerebrovascular events [ 13 , 14 ]. Previous studies related to the sdLDL-C mainly focused on the patients who have experienced cardiovascular and cerebrovascular events [ 15 , 16 ]. For instance, studies have shown that sdLDL-C is an independent risk factor for IMT in acute ischemic stroke [ 17 ], as well as for unstable plaques in acute cerebral infarction (ACI) patients [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness

Liu¹,

Wang²,

Cao³

et al. 2021

BMC Cardiovasc Disord

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Aim To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with subclinical atherosclerosis. Methods A total of 729 subjects were randomly collected from consecutive individuals from April 2019 to April 2020 for an annual health checkup. CA-IMT > 1.0 mm was defined as abnormal IMT. Plaque stability was measured by ultrasound examination based on the property of the echo. And sdLDL-C levels were detected by LipoPrint system. Multivariate logistic regression analysis was performed to identify factors associated with CA-IMT and carotid plaque. Results The abnormal IMT group had significantly higher sdLDL-C levels than control group (p < 0.0001). And sdLDL-C levels were significantly positively correlated with IMT value (r = 0.1396, p = 0.0021) and presence of carotid plaque (r = 0.14, p = 0.002) in the subjects with abnormal IMT. In addition, subjects with higher levels of sdLDL-C (r = 0.11, p = 0.035) tended to have unstable CAP. After adjustment for age, gender and blood glucose, sdLDL-C level was an independent risk factor of the presence of CAP (OR = 1.59, 95% CI: 1.02–1.83, p = 0.034) in subjects with abnormal IMT. Conclusion SdLDL-C is an independent risk factor of the occurrence of CAP in the Chinese subjects with abnormal IMT. Our findings provide supporting evidence that sdLDL-C might be an alternative way to predict CVD in early stage.

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Estimation of the LDL subclasses in ischemic stroke as a risk factor in a Chinese population

Cited by 19 publications

References 25 publications

The Role of Small Dense Low-Density Lipoprotein Cholesterol in the Prediction of Acute Myocardial Infarction

The Role of Small Dense Low-Density Lipoprotein Cholesterol in the Prediction of Acute Myocardial Infarction

Atherogenic Index of Plasma Predicts Outcomes in Acute Ischemic Stroke

Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness

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