Atherogenic Index of Plasma Predicts Outcomes in Acute Ischemic Stroke

Abstract

Aim: The atherogenic index of plasma (AIP) was significantly related to adverse outcomes in patients with cardiovascular disease. Our aim was to investigate the association between AIP and adverse outcomes in acute ischemic stroke.Methods: Patients with acute ischemic stroke (AIS) admitted between 2015 and 2018 were prospectively enrolled in this study. Functional outcomes were evaluated by the modified Rankin Scale (mRS). Poor outcomes were defined as mRS 3–6. The relationship of AIP with the risk of outcomes was analyzed by multivariate logistic regression models.Results: A total of 1,463 patients with AIS within 24 h of symptom onset were enrolled. The poor outcome group had a significantly higher level of AIP [0.09 (−0.10 to 0.27) vs. 0.04 (−0.09 to 0.18), p < 0.001] compared with the good outcome group. Multivariable logistic regression analysis showed that higher AIP was associated with poor outcomes in all the stroke patients (OR 1.84, 95% CI, 1.23–2.53, p = 0.007), which was more evident in patients with large-artery atherosclerosis subtype (OR 1.90, 95% CI, 1.53–2.62, p = 0.002), but not in the other subtypes. Receiver operating curve (ROC) analysis revealed that the best predictive cutoff value of AIP was 0.112, with a sensitivity of 70.8% and a specificity of 59.2%, and the area under the ROC curves for AIP was 0.685.Conclusion: AIP may be an important and independent predictor of the outcome of dysfunction in patients with AIS, especially the stroke subtype of large-artery atherosclerosis.

Atherogenic Index of Plasma in Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

“…Hence, NAFLD patients present an increased CV risk [ 21 , 22 , 23 ]. The atherogenic index of plasma (AIP), a novel quantitative index utilized to assess lipid levels, is a strong marker of dyslipidemia [ 24 , 25 ]. The logarithmic ratio between triglyceride levels and HDL-C yields the AIP, which indicates the association between atherogenic and protective lipoprotein [ 26 ].…”

Atherogenic index of plasma is associated with the risk of myocardial infarction: a prospective cohort study

“…A secondary analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study showed AIP was an independent risk factor among the patients with type 2 diabetes mellitus AIP 28 . A recent registry study revealed that AIP could be associated with the outcome of dysfunction in patients with acute ischemic stroke, and this study also further evaluated the predictive values of blood lipid and found AIP was the best discriminating variable to predict poor outcomes, death, and disability 29 . In line with those past studies, our study of 98 861 participants with significant statistical power showed that the quartile 4 group of the baseline AIP had a 1.98-fold higher risk of MI compared with the quartile 1 group, and this significant association of a higher risk of MI in the quartile 4 group persisted after adjusting all potential covariates.…”

Is the Atherogenic Index of Plasma (AIP) a Cardiovascular Disease Marker?

“…27 AIP may be a reliable indicator of acute ischemic stroke, particularly the stroke subtype of large-artery atherosclerosis. 28 According to Kim et al, high AIP predicts IHD in non-diabetic Koreans. As an alternative to isolated TG levels or other lipid markers, AIP is increasingly used to stratify distinct cardiometabolic risks.…”