2007
DOI: 10.1198/106186007x255991
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Estimation of Smooth Time-Varying Parameters in State Space Models

Abstract: In this article, we propose a penalized likelihood method to estimate time-varying parameters in standard linear state space models. The time-varying parameter is modeled as a smoothing spline and then expressed as a state space model. The maximum likelihood method is used to estimate the smoothing parameter. The proposed method is assessed by a simulation study and applied to virological response data from an HIV-infected patient receiving antiretroviral treatment.

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Cited by 5 publications
(4 citation statements)
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“…Ramsay, Hooker, Campbell and Cao (2007) consider modeling a continuously stirred tank reactor. Zhu and Wu (2007) adopt a state space approach for estimating the dynamics of cell-virus interactions in an AIDS clinical trial. Poyton et al (2006) use the principal differential analysis approach to fit dynamical systems.…”
Section: Introductionmentioning
confidence: 99%
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“…Ramsay, Hooker, Campbell and Cao (2007) consider modeling a continuously stirred tank reactor. Zhu and Wu (2007) adopt a state space approach for estimating the dynamics of cell-virus interactions in an AIDS clinical trial. Poyton et al (2006) use the principal differential analysis approach to fit dynamical systems.…”
Section: Introductionmentioning
confidence: 99%
“…In a recent work, Cao, Fussmann and Ramsay (2008) model a nonlinear dynamical system using splines with predetermined knots for describing the gradient function. Most of the existing approaches assume known functional forms of the dynamical system; and many of them require data measured on a dense grid (e.g., Varah, 1982;Zhu and Wu, 2007).…”
Section: Introductionmentioning
confidence: 99%
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“…A recent advance in time series analysis is the development of autoregressive (AR) models, and more generally autoregressive moving average models, with time-varying coefficients. Such models are developed as in Gersch (1985, 1996), Dahlhaus (1997), West et al (1999), Prado and Huerta (2002), Andrieu et al (2003), Lundbergh et al (2003), Francq and Gautier (2004), Moulines et al (2005), Huerta and Prado (2006), Abramovich et al (2007), Triantafyllopoulos and Nason (2007), and Zhu and Wu (2007). All these studies refer to univariate time series; attempts to model vector time series with time-varying autoregressive (TV-VAR) models include Jiang and Kitagawa (1993), Sarantis (2006), Sato et al (2007), and Triantafyllopoulos (2007).…”
Section: Introductionmentioning
confidence: 99%