Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia

Chandrakala, J; Monappa, Vidya; Hemavathy, S; Srinath, Sahana; Suresh, T N; Yadav, T Satish

doi:10.4103/jomfp.jomfp_69_14

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…Characteristic reticular appearance of OLP can be observed alone or in combination with erythematous and erosive lesions. [1][2][3]16,17,19,20 In this study, the most common type was the mixed type (63.3%). Consistent with the literature, buccal mucosa was the most frequently affected area, followed by tongue and gingiva.…”

Section: Discussionmentioning

confidence: 66%

“…The prevalence of OLP is reported as 0.5% -2.2%. 1,2 Spontaneous remission is rarely seen in the resistant cases and malign transformation has been reported to vary between 0% and 12.5% in the studies. [3][4][5][6][7] Because of the chronic nature of the disease and the risk of malign transformation, it is recommended to follow these patients by regular controls.…”

Section: Introductionmentioning

confidence: 99%

“…1,3,4,[6][7][8] Oral lichenoid dysplasia (OLD) is a precancerous process with lichenoid features which is frequently confused with OLP. 2 A variety of methods and devices are being developed to ensure early diagnosis of premalignant and malignant lesions that are difficult to distinguish. One of these is staining with toluidine blue stain.…”

Section: Introductionmentioning

confidence: 99%

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Toluidine blue application to detect dysplasia and malignant changes in patients with oral lichenoid lesions

Taşkın¹,

Türk²,

Kandıloğlu³

et al. 2018

Mucosa

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Background Oral lichen planus (OLP) is a chronic disease with immune-mediated pathogenesis which can be premalignant. Oral lichenoid dysplasia (OLD) is a precancerous process with lichenoid features which is frequently confused with OLP. Objective In this study, we aimed to investigate the efficacy of toluidine blue (TB) administration before biopsy to detect the dysplastic changes in patients who were clinically diagnosed with OLP. Methods Thirty consecutive patients with oral lichenoid lesions whose clinical findings were consistent with OLP were included in the study. Demographic and clinical characteristics of the patients studied were recorded and clinical photos were taken before and after the administration of TB. Areas to be biopsied were determined according to the results of the TB staining. Histopathologically, all the specimens were evaluated in terms of the diagnostic features of OLP and the presence of dysplastic findings. ResultsThe mean age of the 30 patients (21 females, 9 males) included in the study was 51.03 (26-70 years) and the median value of disease duration was 12.00 ± 67.23 months (2-360 months). Six patients (20.0%) had positive staining after application of TB. Histopathological examination revealed OLP findings in 17 patients (56.7%), OLP and dysplasia findings in nine patients (30.0%) and lichenoid dysplasia in four patients (13.3%). Dysplasia was detected in all of the lesions (six patients) which were stained blue with TB. The relationship between staining and dysplasia was significant (p<0.05). OLP and dysplasia were observed in four of these six patients (66.7%), and lichenoid dysplasia was observed in the other two (33.3%). The relationship between presence of dysplasia and presence of mitosis was found statistically significant in patients with histopathological dysplasia (p<0.05). When the presence of mitosis was evaluated in biopsies taken from the stained lesions, a statistically significant relation was found (p<0.05). Conclusions In our study, it was observed that dysplasia was detected in all stained areas after the application of TB to clinically classical OLP patients, but there was no staining in some patients despite the presence of dysplasia. Therefore, the sensitivity of the application was 46%, specificity was 100%, positive predictive value was 100% and negative predictive value was 70.8%. TB application is a specific test to detect the dysplasia; however because of the low sensitivity in oral lichenoid lesions, another method is needed to increase the sensitivity.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Toluidine blue application to detect dysplasia and malignant changes in patients with oral lichenoid lesions

Taşkın¹,

Türk²,

Kandıloğlu³

et al. 2018

Mucosa

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“…This induction of epithelial alterations would not be such as to mimic more severe dysplastic degrees. When moderate or severe dysplasia were present, the cases were classi ed as oral lichenoid lesions [12,15,[18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a clinicopathological, transversal study

Moreira¹,

Maia¹,

Zimbrão

et al. 2023

Preprint

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Background Clinicopathological diagnosis and follow-up of oral lichen planus and leukoplakia are necessary due to its potential for malignant transformation and the need to differentiate it from other lichenoid diseases and proliferative verrucous leukoplakia. This study aimed to classify and compare sociodemographic and clinicopathological features among oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia. Methods: A transversal observational study was conducted in which oral leukoplakia and oral lichen planus cases were surveyed at the Oral Pathological Anatomy Service and Applied Biotechnology Laboratory. Sociodemographic and clinicopathological data were compared regarding the lesions studied with the chi-square or Fisher’s exact test. Results: After classification, 21 oral lichen planus, 34 oral lichenoid lesions and 12 proliferative verrucous leukoplakia cases were evaluated. Reticular patterns are more characteristic of oral lichen planus and plaque lesions of proliferative verrucous leukoplakia. Buccal mucosa was the most affected site in oral lichen planus lesions and they were bilateral in all cases. Epithelial dysplasia was present in almost all cases of proliferative verrucous leukoplakia. Conclusion: Oral lichenoid lesions presented intermediate features when compared to oral lichen planus and proliferative verrucous leukoplakia. This may delay proliferative verrucous leukoplakia diagnosis.

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“…The etiology has not been fully elucidated [7]. The pathological changes of LP show hyperkeratosis of the epidermis, irregular thickening of the spine layer, and wedge-shaped granules in the epidermis with focal thickening, liquefaction degeneration of the basal cells, and a large number of lymphocyte infiltration in the dermis, which is an important basis for the diagnosis of LP [8,9].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Immunologic Function Changes in Lichen Planus After Clinical Treatment

et al. 2018

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BackgroundLichen planus (LP) is a common chronic superficial skin lesion that causes chronic or sub-acute inflammatory disorders. LP can affect the oral cavity, skin, mucous membrane, and other body parts, and features include repeat attacks and long duration, leading to lower quality of life. This study aimed to analyze the changes of immunologic function before and after treatment of LP.Material/MethodsThirty cutaneous LP patients were selected. Peripheral blood was collected in the morning before and after treatment. Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient method. Flow cytometry was used to detect T cell subpopulation CD4+ T cells and CD8+ T to calculate CD4+ T/CD8+ T ratio. Enzyme-linked immunosorbent assay (ELISA) was adopted to detect the helper T-cell (Th) factor IL-2, IFN-γ, IL-4, IL-6, IL-17, and IL-22 levels.ResultsCompared with before treatment, the expressions of CD4+ T cells and CD8+ T cells were decreased, while the proportion of CD4+ T/CD8+ T were significantly elevated after treatment. IL-2 and IFN-γ secretion were markedly increased, whereas IL-4, IL-6, IL-17, and IL-22 were significantly reduced after treatment (P<0.05).ConclusionsLP treatment reduces the distribution of CD4+ T cells and CD8+ T cells, and promotes the changes of Th1, Th2, and Th17 cytokines secretion.

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Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia

Cited by 3 publications

References 24 publications

Toluidine blue application to detect dysplasia and malignant changes in patients with oral lichenoid lesions

Toluidine blue application to detect dysplasia and malignant changes in patients with oral lichenoid lesions

Comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a clinicopathological, transversal study

Analysis of Immunologic Function Changes in Lichen Planus After Clinical Treatment

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