Estimation of serum lipids in patients with Oral Submucous Fibrosis in India

Abstract

Objectives: Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India. Low levels of lipids serves as a marker and prognostic indicator in the early detection of oral precancerous and cancerous states. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not widely been investigated with respect to the serum lipid levels. In the present study, an attempt was made to analyze the complete serum lipid profile, total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol in OSMF and controls. Material and Methods: The study was conducted in 45 clinically and histopathologically diagnosed cases of OSMF and 45 age and sex matched controls. The complete lipid profile including TC, TG, HDL cholesterol, LDL cholesterol and VLDL cholesterol was analyzed. Results: The serum lipid levels were significantly lower in the patients with OSMF than in the controls. When the values were compared between different disease stages, the maximum reduction of lipids was evident for stage 3 OSMF. From the present results, it is evident that the level of serum lipids decreases with progression of the disease. Conclusions: From these findings, it appears that the decrease in the lipid levels may be considered as a useful marker in the early diagnosis of oral premalignant condition like OSMF. Key words:Oral submucous fibrosis, lipids, premalignant condition.

Lipid profile in oral potentially malignant disorders and oral squamous cell carcinoma – A prognostic view

“…Thus, affecting essential constituents of the cell membrane and might be involved in tumorigenesis resulting in greater utilization of lipids. Our findings are in total agreement with Altaf H Chalkoo et al ,[ 18 ] Gupta N et al ,[ 19 ] Mayeesh Radhakrishna et al ,[ 20 ] Ajai K et al ,[ 21 ] Goel P et al . [ 22 ]…”

Alteration of Serum Lipid in Oral Sub Mucous Fibrosis in Central India

“…In our study serum lipids are significantly reduced in OSMF patients group when compared with control, shows similar results as Study carried out by Ajai et al [1] reported significant reduction in serum TC, serum TG, serum HDL, serum LDL and serum VLDL. Patel et al [12] showed similar results in patients with oral squamous cell carcinoma.…”

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

“…24 The results of the present study show that total cholesterol, TG, HDL, and LDL were significantly reduced in the OSCC and OPC groups when compared with the reference values which is in agreement with studies reported by Ashutosh et al and Garg et al 25,26 Other studies have also reported decreased lipid levels in cancer patients but with variable lipid profile patterns as compared to control group. [27][28][29][30][31][32][33][34][35][36][37][38] Lohe et al and Patel et al found a significant decrease in TC, HDL, VLDL, and TG but not in LDL in patients with OSCC. 1,8 Acharya et al reported significant decrease in TC, HDL, LDL, and VLDL but not for TG in patients with OSCC.…”