Estimation Of Salivary Superoxide Dismutase Level In Oral Submucous Fibrosis: A Clinical And Biochemical Study

Akhlaq, Humera; Ismail, Muhammad Owais; Samad, Muhammad Abdul

doi:10.51985/jbumdc2018106

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Another study showed that saliva SOD levels in patients with OSMF decreased significantly, which to some extent reflected the decline of antioxidant capacity in patients with OSMF. Researchers found that mouth opening in OSMF patients decreased with the decrease of SOD levels [31] .…”

Section: Oral Submucosal Fibrosis and Oxidative Stressmentioning

confidence: 99%

Relationship between Oxidative Stress and Several Common Oral Mucosal Diseases: A Review

2023

IJFM

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Free radicals include reactive oxygen species and reactive nitrogen, which are vital substances in the biological process of the body, which have a positive effect on the human body at normal concentrations. When the content of free radicals is too high, the body will activate the antioxidant system to defend against this damage in order to protect itself. The disorder of the balance between pro-oxidative and antioxidant reactions will lead to oxidative stress: excessive production of free radicals, and the body's antioxidant system cannot effectively resist this invasion, free radicals destroy the molecular tissues that make up DNA, proteins and lipids, followed by irreversible damage. Many studies at home and abroad have shown that patients with some oral mucosal diseases (recurrent aphthous ulcer, oral lichen planus, oral leukoplakia, oral submucosal fibrosis, burning mouth syndrome) often observe oxidative stress in oral tissue or saliva and blood, and explore many potential biomarkers. Through the study of the relationship between oxidative stress and oral mucosal diseases, it will be of guiding significance for the etiological exploration and treatment of oral mucosal diseases. This article reviews the latest research progress on the relationship between oxidative stress and several common oral mucosal diseases in recent years.

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Section: Oral Submucosal Fibrosis and Oxidative Stressmentioning

confidence: 99%

Relationship between Oxidative Stress and Several Common Oral Mucosal Diseases: A Review

2023

IJFM

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A Comparative Investigation of the Activity of Superoxide Dismutase in Patients with Leukoplakia and Healthy Controls

Purushothaman¹,

Kuthoor²,

Sunil³

et al. 2022

Indian Journal of Dental Research

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Context and Aim: Oral leukoplakia has recently been re-defined as “a predominantly white lesion of the oral mucosa that cannot be characterised as any other definable lesion”. Superoxide dismutase (SOD) is one of the enzymatic anti-oxidants which form the first line of defence in the cell. There are very limited data available on the analysis of SOD in leukoplakia patients. Therefore, the present study was planned to analyse anti-oxidant SOD levels in leukoplakia patients. Methods and Material: The study group consisted of 29 subjects of oral leukoplakia, and the control group consisted of 25 healthy individuals. All the subjects were evaluated for SOD enzyme in plasma. Statistical Analysis Used: The results for each determinant were calculated using one-way ANOVA test, Student 't' test, Pearson Chi square test, and 't' test for equality of means wherever applicable. Results: The study revealed that among the different clinical entities of oral leukoplakia, the enzymatic anti-oxidant SOD is shown to have decreased in all forms of oral leukoplakia, but without any statistical significance. A statistically highly significant decrease (at P < 0.0001) of SOD in oral leukoplakia patients compared to normal healthy patients was observed in the present study. Conclusions: The study revealed a difference in the free-radical activity and oxidative stress in blood of leukoplakia patients compared to healthy patients, which is reflected by the variation in the levels of blood SOD, thus showing vulnerability to cellular damage and tendency towards further malignant changes.

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Estimation Of Salivary Superoxide Dismutase Level In Oral Submucous Fibrosis: A Clinical And Biochemical Study

Cited by 2 publications

References 20 publications

Relationship between Oxidative Stress and Several Common Oral Mucosal Diseases: A Review

Relationship between Oxidative Stress and Several Common Oral Mucosal Diseases: A Review

A Comparative Investigation of the Activity of Superoxide Dismutase in Patients with Leukoplakia and Healthy Controls

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