Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)

Polańska, Kinga; Król, Anna; Kałużny, Paweł; Ligocka, Danuta; Mikołajewska, Karolina; Shaheen, Seif O.; Hanke, Wojciech

doi:10.3390/ijerph13121216

Cited by 28 publications

(32 citation statements)

References 30 publications

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“…Based on existing knowledge and our previous estimates there is no gold standard for assessment of ETS exposure [ 20 ]. Thus, in our study, prenatal ETS was measured by assessing mother’s cotinine levels in saliva during pregnancy and, additionally, by collecting (at the same time as the sample collection) the questionnaire information about their husband/partner smoking and smoking allowance at home.…”

Section: Methodsmentioning

confidence: 99%

“…In Poland, based on the Global Adult Tobacco Survey that was conducted between the years 2009 and 2010 about 30% of the non-smoking women were exposed to tobacco smoke at home [ 19 ]. Our previous assessments that covered 1771 women from the Polish Mother and Child Cohort (REPRO_PL) have indicated that about 15% of them can be classified as active, and about 35% as passive smokers according to their cotinine level in saliva [ 20 ]. We have also noted adverse effects of maternal active smoking during pregnancy on child motor development [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment

Polańska

Król

Merecz-Kot

et al. 2017

IJERPH

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The developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data. The cotinine cut-off value for passive smoking was established at 1.5 ng/mL (sensitivity 63%, specificity 71%). Psychomotor development was assessed in children at the age of one- and two-years using the Bayley Scales of Infant and Toddler Development. Approximately 30% of the women were exposed to ETS during pregnancy. The multivariate linear regression model indicated that ETS exposure in the 1st and the 2nd trimesters of pregnancy were associated with decreasing child language functions at the age of one (β = −3.0, p = 0.03, and β = −4.1, p = 0.008, respectively), and two years (β = −3.8, p = 0.05, and β = −6.3, p = 0.005, respectively). A negative association was found for cotinine level ≥1.5 ng/mL in the 2nd trimester of pregnancy and child cognition at the age of 2 (β = −4.6, p = 0.05), as well as cotinine levels ≥1.5 ng/mL in all trimesters of pregnancy and child motor abilities at two years of age (β = −3.9, p = 0.06, β = −5.3, p = 0.02, and β = −4.2, p = 0.05, for the 1st, the 2nd, and the 3rd trimester of pregnancy, respectively; for the 1st trimester the effect was of borderline statistical significance). This study confirmed that ETS exposure during pregnancy can have a negative impact on child psychomotor development within the first two years of life and underscore the importance of public health interventions aiming at reducing this exposure.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment

Polańska

Król

Merecz-Kot

et al. 2017

IJERPH

Self Cite

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“…After performing the Cotinine test strips the subjects distribution by their smoking status was represented as: 44.06% active smokers, 39.50% passive smokers and 16.43% non-smokers [26]. These results showed that more than a half of the subjects participating in this study self-declared being nonsmokers, but this percent decreased dramatically after the test performing, and higher frequency of positive Cotinine levels was encountered in women than in men [26,27,28].…”

Section: Discussionmentioning

confidence: 99%

Research Article. Relationship Between High Levels of Salivary Cotinine Test and Demographic Characteristics of Pregnant Smokers from Mures County

Georgescu

Tarcea

Mărginean³

et al. 2017

Acta Medica Marisiensis

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Objectives: To evaluate the relationship between the frequency of self-declared status regarding smoking in a group of pregnant women from Mures county, Romania and the high levels of Salivary Cotinine (SC) like biomarkers. Material and methods: It was conducted a retrospective study among 230 pregnant women presented for prenatal care at 50 General Practitioners cabinets in Mures county, Romania, in 2015. Data were collected with a validated questionnaire which included age, level of education, socioeconomic status and ethnicity, also the selfreported smoking status. The Salivary Cotinine level was evaluated using NicAlert Saliva test kits. Results: Using salivary test we identified a high prevalence of involuntary exposure to cigarette smoke among both non-smokers and those who quit smoking before pregnancy. Also we registered pregnant women that although declared smoking cessation before pregnancy their salivary Cotinine levels were high, almost like to an active smoker, probably because of second-hand exposure or because they didn't say the truth about their habit. Conclusions: We underline the importance of implementing more efficient community interventions among this vulnerable group in order to reduce the frequency of smoking and sustain quitting.

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“…Studies examining the association of education and income with SHS exposure during pregnancy are limited [4][5][6][7][8][9][10][11], while there is substantial evidence that those with lower education and/or lower income are more exposed to SHS than higher ones in the general population [1,[12][13][14][15][16]. Although education and income re ect the central dimension of social strati cation, they have different meanings in society; education is thought to capture knowledge and skills, while income measures material resources to enhance health [17].…”

Section: Introductionmentioning

confidence: 99%

“…Although education and income re ect the central dimension of social strati cation, they have different meanings in society; education is thought to capture knowledge and skills, while income measures material resources to enhance health [17]. Existing studies among pregnant women have mainly focused on education [4,6,[8][9][10][11], and the association between income and SHS exposure have rarely been examined [5,7]. To the best of our knowledge, no studies have examined the association of education and income with SHS exposure during pregnancy in Japan.…”

Section: Introductionmentioning

confidence: 99%

Associations of Education and Income With Secondhand Smoke Exposure Among Non-Smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Murakami¹,

Obara²,

Ishikuro³

et al. 2020

Preprint

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Background: Associations of education and income with secondhand smoke (SHS) exposure have been well documented in the general population. However, evidence among non-smoking pregnant women is limited, including in Japan. The purpose of the study was to examine the associations of education and income with SHS exposure among non-smoking pregnant women in Japan.Methods: We analyzed data from 17815 non-smoking pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SHS exposure was defined as indoor exposure to someone else’s cigarette smoke ≥1 day/week during pregnancy. Multiple logistic regression analyses were conducted to examine whether pregnant women’s educational attainment or equivalent household income was associated with SHS exposure, adjusting for age, work status, smoking history, partners’ education, and income/education. Stratified analyses by work status were also conducted.Results: The prevalence of SHS exposure during pregnancy was 34.0%; 29.4% among non-working women and 37.1% among working women. Lower educational attainment was associated with an increased risk of SHS exposure; the odds ratio of high school education or lower compared with university education or higher was 1.78 (95% confidence interval, 1.59–1.99). Lower equivalent household income was associated with an increased risk of SHS exposure; the odds ratio of the lowest compared with the highest level of income was 1.67 (95% confidence interval, 1.51–1.84). These associations did not differ between non-working women and working women.Conclusions: Pregnant women with lower education and/or lower household income had higher risks of SHS exposure in Japan. These findings imply that educational interventions and financial incentives are needed for pregnant women and their household smokers in helping to reduce SHS exposure among non-smoking pregnant women.

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Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)

Cited by 28 publications

References 30 publications

Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment

Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment

Research Article. Relationship Between High Levels of Salivary Cotinine Test and Demographic Characteristics of Pregnant Smokers from Mures County

Associations of Education and Income With Secondhand Smoke Exposure Among Non-Smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

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