Estimation of Nasal Tip Support Using Computer-Aided Design and 3-Dimensional Printed Models

Gray, Eric J.; Maducdoc, Marlon; Manuel, Cyrus; Wong, Brian J. F.

doi:10.1001/jamafacial.2016.0215

Cited by 12 publications

(8 citation statements)

References 37 publications

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“…The silicone Ecoflex 00‐10 (Smooth‐On Inc., Macungie, PA) was selected due to its low modulus of elasticity, tear resistance, compatibility with 3D printed parts, and the ability to vary the modulus of elasticity by adding a silicone thinner (Smooth‐on Inc.) (Gray et al. ). A vacuum chamber was used to remove all air bubbles from the silicone mixture prior to pouring the silicone into the mold.…”

Section: Methodsmentioning

confidence: 99%

Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid‐structure interaction simulations and experiments

Moghaddam

Woodson

et al. 2019

Physiol Rep

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The classical Starling Resistor model has been the paradigm of airway collapse in obstructive sleep apnea ( OSA ) for the last 30 years. Its theoretical framework is grounded on the wave‐speed flow limitation ( WSFL ) theory. Recent observations of negative effort dependence in OSA patients violate the predictions of the WSFL theory. Fluid‐structure interaction ( FSI ) simulations are emerging as a technique to quantify how the biomechanical properties of the upper airway determine the shape of the pressure‐flow curve. This study aimed to test two predictions of the WSFL theory, namely (1) the pressure profile upstream from the choke point becomes independent of downstream pressure during flow limitation and (2) the maximum flowrate in a collapsible tube is , where ρ is air density and A and P are the cross‐sectional area and pressure at the choke point respectively. FSI simulations were performed in a model of the human upper airway with a collapsible pharynx whose wall thickness varied from 2 to 8 mm and modulus of elasticity ranged from 2 to 30 kP a. Experimental measurements in an airway replica with a silicone pharynx validated the numerical methods. Good agreement was found between our FSI simulations and the WSFL theory. Other key findings include: (1) the pressure‐flow curve is independent of breathing effort (downstream pressure vs. time profile); (2) the shape of the pressure‐flow curve reflects the airway biomechanical properties, so that is a surrogate measure of pharyngeal compliance.

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Section: Methodsmentioning

confidence: 99%

Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid‐structure interaction simulations and experiments

Moghaddam

Woodson

et al. 2019

Physiol Rep

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“…This may be found in nasal casts from Koken® or Teijin Pharma®. However, alternative materials, such as acrylonitrile butadiene styrene (Gray et al, 2016) or polypropylene (Xi et al, 2016a,b), may also be used. 3D-specific materials (e.g.…”

Section: Deposition Studies In Nasal Cavities Using a Nasal Castmentioning

confidence: 99%

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

Salade

Wauthoz

Goole

et al. 2019

International Journal of Pharmaceutics

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Nasal delivery offers many benefits over other conventional routes of delivery (e.g. oral or intravenous administration). Benefits include, among others, a fast onset of action, non-invasiveness and direct access to the central nervous system. The nasal cavity is not only limited to local application (e.g. rhinosinusitis) but can also provide direct access to other sites in the body (e.g. the central nervous system or systemic circulation). However, both the anatomy and the physiology of the nose impose their own limitations, such as a small volume for delivery or rapid mucociliary clearance. To meet nasal-specific criteria, the formulator has to complete a plethora of tests, in vitro and ex vivo, to assess the efficacy and tolerance of a new drug-delivery system. Moreover, depending on the desired therapeutic effect, the delivery of the drug should target a specific pathway that could potentially be achieved through a modified release of this drug. Therefore, this review focuses on specific techniques that should be performed when a nasal formulation is developed. The review covers both the tests recommended by regulatory agencies (e.g. the Food and Drug Administration) and other complementary experiments frequently performed in the field.

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“…This is particularly true in facial plastics and reconstruction where functional and aesthetic outcomes are paramount. 49 In a recent mouse model study, artificial nasal alar cartilage was fabricated from the 3D printing of gum resin. 50 In the future, such structures could be used in conjunction with human cells to reconstruct the nasal cartilaginous skeleton.…”

Section: Three-dimensional Modelingmentioning

confidence: 99%

Three‐Dimensional Printing and Its Applications in Otorhinolaryngology–Head and Neck Surgery

Crafts

Ellsperman

Wannemuehler

et al. 2016

Otolaryngol.--head neck surg.

135

101

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Objective: Three-dimensional printing technology is being employed in a variety of medical and surgical specialties to improve patient care and advance resident physician training. As the costs of implementing three-dimensional printing have declined, the use of this technology has expanded, especially within surgical specialties. This article explores the types of threedimensional printing available, highlights the benefits and drawbacks of each methodology, provides examples of how three-dimensional printing has been applied within the field of otolaryngology -head and neck surgery, discusses future innovations, and explores the financial impact of these advances.Data Sources: Articles were identified from PubMed and Ovid Medline.Review Methods: PubMed and Ovid Medline were queried for English articles published between 2011and 2016, including a few articles prior to this time as relevant examples. Search terms included: three-dimensional printing, 3D-printing, otolaryngology, additive manufacturing, craniofacial, reconstruction, temporal bone, airway, sinus, cost, and anatomic models.Conclusions: Three-dimensional printing has been used in recent years in otolaryngology for preoperative planning, education, prostheses, grafting, and reconstruction. Emerging technologies include the printing of tissue scaffolds for the auricle and nose, more realistic training models, and personalized implantable medical devices. Implications for Practice:After accounting for the upfront costs of three-dimensional printing, its utilization in surgical models, patient-specific implants, and custom instruments can reduce operating room time and thus decrease costs. Educational and training models provide an opportunity to better visualize anomalies, practice surgical technique, predict problems that might arise, and improve quality by reducing mistakes.3

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Estimation of Nasal Tip Support Using Computer-Aided Design and 3-Dimensional Printed Models

Cited by 12 publications

References 37 publications

Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid‐structure interaction simulations and experiments

Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid‐structure interaction simulations and experiments

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

Three‐Dimensional Printing and Its Applications in Otorhinolaryngology–Head and Neck Surgery

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