Estimation of Lipoprotein-lipase Activity (LPL) and Other Biochemical Changes in Two Breeds of Overfeeding Geese

Xu, Hengyong; Wang, Yan; Han, Chunchun; Jiang, Li; Wu, Zhuo; Ye, Jianqiang; Wang, Jiwen

doi:10.5713/ajas.2010.10013

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…Under natural conditions, birds, especially some wild waterfowl, are more likely to show non-pathological hepatic steatosis as a result of energy storage before migration [ 23 ]. To identify the genetic mechanism underlying the occurrence of fatty liver, many previous studies have focused on goose fatty liver formation [ 5 - 7 , 24 , 25 ]. However, to date, the adaptive molecular mechanisms that induce higher synthesis of hepatic lipids, especially unsaturated fatty acids, in response to carbohydrate-rich diets remain to be understood in waterfowl species.…”

Section: Resultsmentioning

confidence: 99%

“…In agricultural production, this particular phenotype is manifested following short-term overfeeding (approximately 2 to 3 weeks), resulting in fatty livers and a 5- to 10-fold increase in liver size [ 5 ]. Previous studies have shown that the serum enzyme levels of overfed geese are similar to those observed in humans with non-alcoholic fatty liver disease [ 5 - 7 ], suggesting that the unique fat storage and metabolic characteristics of goose liver may be an important reference for the study of lipid metabolism disorders in humans.…”

Section: Introductionmentioning

confidence: 93%

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The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver

et al. 2015

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BackgroundGeese were domesticated over 6,000 years ago, making them one of the first domesticated poultry. Geese are capable of rapid growth, disease resistance, and high liver lipid storage capacity, and can be easily fed coarse fodder. Here, we sequence and analyze the whole-genome sequence of an economically important goose breed in China and compare it with that of terrestrial bird species.ResultsA draft sequence of the whole-goose genome was obtained by shotgun sequencing, and 16,150 protein-coding genes were predicted. Comparative genomics indicate that significant differences occur between the goose genome and that of other terrestrial bird species, particularly regarding major histocompatibility complex, Myxovirus resistance, Retinoic acid-inducible gene I, and other genes related to disease resistance in geese. In addition, analysis of transcriptome data further reveals a potential molecular mechanism involved in the susceptibility of geese to fatty liver disease and its associated symptoms, including high levels of unsaturated fatty acids and low levels of cholesterol. The results of this study show that deletion of the goose lep gene might be the result of positive selection, thus allowing the liver to adopt energy storage mechanisms for long-distance migration.ConclusionsThis is the first report describing the complete goose genome sequence and contributes to genomic resources available for studying aquatic birds. The findings in this study are useful not only for genetic breeding programs, but also for studying lipid metabolism disorders.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-015-0652-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver

et al. 2015

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“…In the control group, higher mTOR gene expression were found in the breast and leg muscles compared with the liver, whereas in the overfed group, mTOR protein content was higher in liver than in the other evaluated tissues. Recent studies found that changes in the expression of mTOR, which is at the heart of a nutrient-sensing signaling network that controls cellular metabolism (Howell & Manning, 2011;Xu et al, 2010), may be related to the different susceptibility levels to overfeeding and to lipid storage and transport in goose tissues.…”

Section: Discussionmentioning

confidence: 99%

“…The tissues in Landes geese present different sensitivity to over feeding (Chunchun et al 2008;Xu et al 2010). The liver is naturally susceptible steatosis, which may increase more than 10-fold in two weeks and account for up to 10% of the body weight after overfeeding with a carbohydrate-rich diet for less than two weeks (Hermier et al, 1994), while muscle and adipose tissue were less developed (Davail et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Change of the Mtor Pathway in Tissues of Overfed Geese

Han

Shen

et al. 2015

Rev. Bras. Cienc. Avic.

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This study aimed at examining the effect of overfeeding on the activity of the mTOR pathway in the liver and muscle tissues of Gang geese. Eighty healthy male Gang geese were reared under the same feeding conditions, and were divided at 14 weeks of age into a control group and an overfed group. All birds were slaughtered after three weeks of over feeding. Gene expression and protein content of several genes involved in the mTOR pathway were evaluated. The results showed that the gene expression of mTOR, raptor, and rictor, and the protein contents of mTOR and PI3K were higher in liver, breast muscle, and leg muscle of the overfed group than that of control group. However, the S6K expression level was clearly lower in the liver of the overfed group than that of control group, and there was no evident difference in both breast muscle and leg muscle between the control group and the overfed group. These results suggest that overfeeding induces the activity of raptor, rictor, and mTOR, and that mTOR signaling pathway was closely linked with PI3K pathway in the evaluated geese. 294

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“…This enzyme is mainly synthesised by adipocytes and muscle cells and is anchored to the surface of the capillary wall, where it is activated by insulin (Xu et al, 2010). In mammals, LPL interacts with apo C-II, which is a low-molecular weight apoprotein secreted with HDLs and transferred to VLDLs prior to hydrolysis .…”

Section: Degradation Of Lipoproteins and Storage Of Lipidsmentioning

confidence: 99%

Lipoprotein metabolism in poultry

Alvarenga

Zangerônimo

Pereira

et al. 2011

World's Poultry Science Journal

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Understanding the metabolism of lipoproteins in birds is important to enable nutritionists to design diets aimed at obtaining better meat characteristics and egg quality, and can furnish useful information for future studies. In comparison to mammals, there are a number of expressive differences in the metabolism of lipids in birds, such as the transport of dietary lipids to the liver, hepatic lipogenesis and the presence of unique lipoproteins in the blood (portomicrons). Greater differences are found in egg-laying hens during the production phase, in which lipoproteins produced in the liver, under the action of oestrogen, are used for the formation of the egg yolk. The regulation of the lipid metabolism by hormones and the participation of key enzymes associated to advances in molecular biology techniques could assist in the genetic selection of more productive birds and better quality products for consumers.

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Estimation of Lipoprotein-lipase Activity (LPL) and Other Biochemical Changes in Two Breeds of Overfeeding Geese

Cited by 8 publications

References 31 publications

The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver

The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver

Change of the Mtor Pathway in Tissues of Overfed Geese

Lipoprotein metabolism in poultry

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