ESTIMATION OF GLOMERULAR FILTRATION RATE IN HEALTHY CATS USING SINGLE‐SLICE DYNAMIC<scp>CT</scp>AND<scp>P</scp>ATLAK PLOT ANALYSIS

Granger, L. Abbigail; Armbrust, Laura J.; Rankin, David C.; Ghering, Ronette; Bello, Nora M.; Alexander, Kate

doi:10.1111/j.1740-8261.2011.01899.x

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…It is known that renal morphology as demonstrated by routine diagnostic imaging techniques and kidney function have low correlation. Scintigraphy (16) and CT-urography with Patlak plot analysis (5) have been described as adequate imaging tools to investigate right and left kidney function separately and quantitatively (1,2,9). Separate evaluation of the renal function in both kidneys is of particular interest in cases where radical nephrectomy is elected as therapeutic option to assure function of the remaining kidney.…”

Section: Discussionmentioning

confidence: 99%

The human Bosniak model applied to a cat with renal cystadenoma

Baloi

Chicca

Ruetten

et al. 2015

Tierarztl Prax Ausg K

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A 13-year-old domestic shorthair cat was presented with weight loss and azotemia. Abdominal ultrasound revealed a large cystic space- occupying lesion with multiple septae in the left kidney. A core needle biopsy yielded a renal cystadenoma originating from the epithelial cells. This report describes the clinical, ultrasonographic and computed tomographic features and the growth progression of a renal cystadenoma. We describe the first attempt to apply the human Bosniak classification to a cat with renal cystic neoplasia to differentiate between benign and malignant lesions. Cystadenoma should be a differential diagnosis in cases of renal cystic space-occupying lesions. Other differentials, imaging features to differentiate benign and malignant lesions and the risk of malignant transformation will be discussed.

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Section: Discussionmentioning

confidence: 99%

The human Bosniak model applied to a cat with renal cystadenoma

Baloi

Chicca

Ruetten

et al. 2015

Tierarztl Prax Ausg K

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“…This method is rapid, less than half an hour including all procedures, compared to the standard clearance method that takes 5‐8 h, and it has been found that the CT‐GFR value correlates well with the gold standard of the plasma clearance method 13,20,22 . Another advantage of this method is that it can measure the individual kidney GFR, which is clinically useful in practice 16,22,14 .…”

Section: Introductionmentioning

confidence: 98%

“…In veterinary medicine, there have been studies of CT-GFR in various species, that is, dogs, [13][14][15][16][17][18][19] pigs, 20,21 horses, 14 and cats. 14,22 The basic concept of a Patlak plot is that the amount of contrast media in the nephron is proportional to the integrated concentration of the contrast media in the aorta during a 2-min dynamic CT scan after contrast media administration.…”

Section: Introductionmentioning

confidence: 99%

“…This method is rapid, less than half an hour including all procedures, compared to the standard clearance method that takes 5-8 h, and it has been found that the CT-GFR value correlates well with the gold standard of the plasma clearance method. 13,20,22 Another advantage of this method is that it can measure the individual kidney GFR, which is clinically useful in practice. 16,22,14 The routine procedure of this technique is based on the attenuation data in HU of each kidney, which comes from a single CT slice scanning over the center of both kidneys in a dorsal 13,15,16 or ventral 14,18,19 recumbency position.…”

Section: Introductionmentioning

confidence: 99%

“…Calculation of CT‐GFR is based on Patlak graphical analysis 12 with single slice dynamic CT. In veterinary medicine, there have been studies of CT‐GFR in various species, that is, dogs, 13–19 pigs, 20,21 horses, 14 and cats 14,22 …”

Section: Introductionmentioning

confidence: 99%

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Assessment of glomerular filtration rate measurement in dogs using dynamic contrast CT compared to serum iohexol clearance

Kaenkangploo

Kampa

Jitpean

et al. 2021

Vet Radiology Ultrasound

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Dynamic contrast CT with Patlak plot analysis can be used to determine the glomerular filtration rate (GFR). However, several studies have shown different GFR values and they are most likely less than the values by the standard techniques. The purpose of this prospective, experimental, and method comparison study was to evaluate the GFR using a CT technique (CT-GFR) in 12 healthy dogs compared to serum iohexol clearance (SIC-GFR). All dogs were anesthetized and placed in the right lateral recumbency position and the caudal part was lifted inside the CT gantry. A single-slice dynamic CT of the aorta and both kidneys was scanned sequentially every 2 s for 2 min after a bolus injection (3 mL/s) of iohexol (300 mg/kg). Time attenuation curves (TAC) were constructed and the GFR per volume of kidney was calculated using the Patlak plot analysis method based on 30-120 s time intervals, and results were compared to global GFR from SIC that was determined with eight blood samples for up to 240 min. The CT-GFR value (1.85 ± 0.48 mL/min/kg) was significantly less than the SIC-GFR value (3.40 ± 0.80 mL/min/kg; P < .05). The CT-GFR was correlated with SIC-GFR by the coefficient of correlation (r) at 0.61 (P = .046). In conclusion, the CT-GFR underestimated SIC-GFR and should be used carefully. We suggest that the GFR should be calculated using the equation derived from linear regression between CT-GFR and the standard GFR method. With its own particular parameters, each institute should have its own prediction equation.

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Normal Urinary System

Hudson

2020

Feline Diagnostic Imaging

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ESTIMATION OF GLOMERULAR FILTRATION RATE IN HEALTHY CATS USING SINGLE‐SLICE DYNAMICCTANDPATLAK PLOT ANALYSIS

Cited by 8 publications

References 36 publications

The human Bosniak model applied to a cat with renal cystadenoma

The human Bosniak model applied to a cat with renal cystadenoma

Assessment of glomerular filtration rate measurement in dogs using dynamic contrast CT compared to serum iohexol clearance

Normal Urinary System

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