Estimation of glomerular filtration rate in South Asian healthy adult kidney donors

Srinivas, S.; Annigeri, Rajeev A; Mk, Mani; Rao, Budithi Subba; Kowdle, Prakash C; Seshadri, R.

doi:10.1111/j.1440-1797.2008.00967.x

Cited by 28 publications

(30 citation statements)

References 30 publications

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“…21 Srinivas et al, evaluated the performance of serum creatinine based equations to estimate GFR in South Asian healthy renal donors and found that the mean GFR was 95.5±11.6 ml/min. 22 Our study too is comparable with earlier reports and the mean eGFR by CG and MDRD equations was found to be 91.05±15.04 and 86.43±13.61 respectively.…”

supporting

confidence: 92%

Assessing Renal Function Using Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Healthy South Indian Males – A pilot study

et al. 2012

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Objective: To compare the estimated GFR (eGFR) calculated by CG and MDRD formulae and to study the correlation between body mass index (BMI) and eGFR in healthy South Indian men. Material & Methods:Healthy male volunteers were enrolled. eGFR was estimated by CG and MDRD equation and categorized as normal, mild, moderate, severe renal impairment and renal failure. Estimated clearance by these two methods was compared using paired student's t test. Correlations were performed with pearson's correlation test.Results: A total of 491 subjects were enrolled. Mean (±SD) eGFR was 91.05 (± 15.04) and 86.43 (± 13.61) by CG and MDRD equations respectively; this difference though statistically significant (p=0.01), was clinically insignificant. A reduced renal function (<90ml/min) was found in 50.9% and 63.1% of population by CG and MDRD formulae respectively. BMI positively correlated with CG-GFR (r=0.471, p<0.001), and negatively correlated with MDRD-GFR (r=-0.268, p<0.001). Serum creatinine positively correlated with BMI (r=0.19, p<0.001). Conclusion:The normal eGFR seems to be lower in the South Indian population compared to the western standards. CG and MDRD formulae may need to be validated before these can be applied for staging of kidney function in a healthy Indian population.

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confidence: 92%

Assessing Renal Function Using Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Healthy South Indian Males – A pilot study

et al. 2012

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“…Our results supported those of Srinivas et al, whose study compared eGFR MDRD and eGFR mC-G with GFR measured by 99mTc-DTPA renal clearance in 599 renal donors; this study demonstrated that eGFR MDRD performed better in terms of global bias, precision, correlation and accuracy than eGFR mC-G . 21 Regarding the validity among studied groups, our study showed that eGFR MDRD had a higher validity than either eGFR C-G or eGFR mC-G in males, those with DM, individuals ≥70 years of age and those who were obese. The eGFR mC-G had higher validity in diabetics, males and those ≥70 years of age than eGFR C-G ; however, in the obese subjects, eGFR mC-G was more sensitive but had less specificity, PPV, NPV and TA than eGFR C-G .…”

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confidence: 98%

Assessment of Glomerular Filtration Rates by Cockcroft-Gault and Modification of Diet in Renal Disease Equations in a Cohort of Omani Patients

Al-Osali¹,

Al-Qassabi²,

Al-Harthi³

2014

SQUMJ

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abstract:Objectives: Glomerular filtration rate (GFR) is the best index of renal function and is frequently assessed by corrected creatinine clearance (CCL cr ). The limitations of CCL cr have inspired researchers to derive easy formulas to estimate GFR, with Cockcroft-Gault (C-G) and the modification of diet in renal disease (MDRD) being the most widely used. This study aimed to evaluate the validity of these equations by finding the relation between CCL cr and estimated GFR (eGFR) by C-G, modified C-G and MDRD equations. Methods: From 2007 to 2011, 158 subjects were analysed for serum creatinine and CCL cr at Bowsher Polyclinic, Muscat, Oman. The C-G equation was used to obtain eGFR C-G which was adjusted to body surface area (BSA) to obtain eGFR mC-G , and the MDRD equation was used to obtain eGFR MDRD . The eGFR MDRD , eGFR mC-G and eGFR C-G were then compared to CCL cr . Results: The eGFR MDRD , eGFR mC-G and eGFR C-G significantly correlated with CCL cr , with a slightly stronger correlation with eGFR MDRD (r = 0.701, 0.658 and 0.605, respectively). A receiver operating characteristic curve analysis showed that the diagnostic accuracy of eGFR MDRD for diagnosing chronic kidney disease (CKD) was higher than that of eGFR mC-G , which in turn was higher than that of eGFR C-G (area under the curve was 0.846, 0.831, and 0.791; cut-off limits were 61.9, 58.3 and 59.5, respectively). Conclusion: C-G and MDRD equations can be an alternative to the CCL cr test for assessing GFR, thus avoiding the need for the cumbersome and expensive GFR test. The MDRD formula had greater validity than the C-G equation and the C-G equation validity was improved by an adjustment to BSA.

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“…Le dé veloppement de la formule de la Mayo Clinic é tait destiné à amé liorer les performances pré dictives dans cette population, inté grant une forte proportion de donneurs vivants potentiels (580 sur un total de 900 patients) [14]. Cependant, deux é tudes tendent à montrer une surestimation importante du DFG dans cette population par cette formule [64,65].…”

Section: Formules D'estimation Du Dfg Et E´pide´miologie De La Maladiunclassified

Exploration de la fonction glomérulaire rénale : estimation du débit de filtration glomérulaire

Maillard

Delanaye

Mariat

2015

Néphrologie & Thérapeutique

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Estimation of glomerular filtration rate in South Asian healthy adult kidney donors

Abstract: The CG GFR equation was better than other equations to estimate GFR in South Asian healthy renal donors. We propose a new equation derived from the regression model in our study population to estimate GFR in a South Asian healthy adult population.

Cited by 28 publications

References 30 publications

Assessing Renal Function Using Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Healthy South Indian Males – A pilot study

Assessing Renal Function Using Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Healthy South Indian Males – A pilot study

Assessment of Glomerular Filtration Rates by Cockcroft-Gault and Modification of Diet in Renal Disease Equations in a Cohort of Omani Patients

Exploration de la fonction glomérulaire rénale : estimation du débit de filtration glomérulaire

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