Assessment of Glomerular Filtration Rates by Cockcroft-Gault and Modification of Diet in Renal Disease Equations in a Cohort of Omani Patients

Abstract

abstract:Objectives: Glomerular filtration rate (GFR) is the best index of renal function and is frequently assessed by corrected creatinine clearance (CCL cr ). The limitations of CCL cr have inspired researchers to derive easy formulas to estimate GFR, with Cockcroft-Gault (C-G) and the modification of diet in renal disease (MDRD) being the most widely used. This study aimed to evaluate the validity of these equations by finding the relation between CCL cr and estimated GFR (eGFR) by C-G, modified C-G and MDRD equations. Methods: From 2007 to 2011, 158 subjects were analysed for serum creatinine and CCL cr at Bowsher Polyclinic, Muscat, Oman. The C-G equation was used to obtain eGFR C-G which was adjusted to body surface area (BSA) to obtain eGFR mC-G , and the MDRD equation was used to obtain eGFR MDRD . The eGFR MDRD , eGFR mC-G and eGFR C-G were then compared to CCL cr . Results: The eGFR MDRD , eGFR mC-G and eGFR C-G significantly correlated with CCL cr , with a slightly stronger correlation with eGFR MDRD (r = 0.701, 0.658 and 0.605, respectively). A receiver operating characteristic curve analysis showed that the diagnostic accuracy of eGFR MDRD for diagnosing chronic kidney disease (CKD) was higher than that of eGFR mC-G , which in turn was higher than that of eGFR C-G (area under the curve was 0.846, 0.831, and 0.791; cut-off limits were 61.9, 58.3 and 59.5, respectively). Conclusion: C-G and MDRD equations can be an alternative to the CCL cr test for assessing GFR, thus avoiding the need for the cumbersome and expensive GFR test. The MDRD formula had greater validity than the C-G equation and the C-G equation validity was improved by an adjustment to BSA.

Association between Food Label Unawareness and Loss of Renal Function in Diabetes: A Cross-Sectional Study in South Korea

“…In this study, the main dependent variable was renal function, which was determined by the Modification of Diet in Renal Disease (MDRD)-estimated glomerular filtration rate (eGFR). The glomerular filtration rate describes the flow rate of filtered fluid from the renal glomerular capillaries into Bowman's capsule per unit time, and it is traditionally considered a credible index of renal function in health and disease [15]. The MDRD model, derived by an equation using serum creatinine, age, ethnicity, and sex, is recommended by many professional guidelines to assess renal function: MDRD eGFR = 175 × Serum Cr -1.154 × age -0.203 × 1.212 (if the patient is black) × 0.742 (if the patient is female) [16].…”