Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Al-Jebouri, Mohemid M.; Al-Mahmood, Balsam Yahya R.

doi:10.4236/mri.2019.81001

Cited by 7 publications

(4 citation statements)

References 20 publications

(18 reference statements)

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“…During the first phase of an injury, IL-6 starts to increase, followed by TNF-α. The level of TNF-α remains in the same current during the injury process [ 15 ]. In this study, rats from the group of cases received DSS to induce colitis.…”

Section: Discussionmentioning

confidence: 99%

Administration of neem (Azadirachta indica A. Juss) leaf extract decreases TNF- and #945; and IL-6 expressions in dextran sodium sulfate-induced colitis in rats

Ruslie

Darmadi

2020

J Adv Vet Anim Res

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Section: Discussionmentioning

confidence: 99%

Administration of neem (Azadirachta indica A. Juss) leaf extract decreases TNF- and #945; and IL-6 expressions in dextran sodium sulfate-induced colitis in rats

Ruslie

Darmadi

2020

J Adv Vet Anim Res

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“…Interestingly, IL-6 and IL-10 were shown to be interesting predictor mediators for SI diagnosed from T1 to T3. As for wound infections, previous studies have shown that patients in medical assistance for SI present elevated levels of IL-6, lasting up to 5 days after intervention [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Profile Associated with Secondary Infection from Bothrops atrox Snakebites in the Brazilian Amazon

Cavalcante,

de Souza,

Neves

et al. 2023

Toxins

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Bothrops snakebite envenomation (SBE) is consider an important health problem in Brazil, where Bothrops atrox is mainly responsible in the Brazilian Amazon. Local effects represent a relevant clinical issue, in which inflammatory signs and symptoms in the bite site represent a potential risk for short and long-term disabilities. Among local complications, secondary infections (SIs) are a common clinical finding during Bothrops atrox SBE and are described by the appearance of signs such as abscess, cellulitis or necrotizing fasciitis in the affected site. However, the influence of SI in the local events is still poorly understood. Therefore, the present study describes for the first time the impact of SBE wound infection on local manifestations and inflammatory response from patients of Bothrops atrox SBE in the Brazilian Amazon. This was an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus (Brazil), involving victims of Bothrops SBE. Clinical and laboratorial data were collected along with blood samples for the quantification of circulating cytokines and chemokines before antivenom administrations (T0) and 24 h (T1), 48 h (T2), 72 h (T3) and 7 days after (T4). From the 94 patients included in this study, 42 presented SI (44.7%) and 52 were without SI (NSI, 55.3%). Patients classified as moderate envenoming presented an increased risk of developing SI (OR = 2.69; CI 95% = 1.08–6.66, p = 0.033), while patients with bites in hands showed a lower risk (OR = 0.20; CI 95% = 0.04–0.96, p = 0.045). During follow-up, SI patients presented a worsening of local temperature along with a sustained profile of edema and pain, while NSI patients showed a tendency to restore and were highlighted in patients where SI was diagnosed at T2. As for laboratorial parameters, leukocytes, erythrocyte sedimentation ratio, fibrinogen and C-reactive protein were found increased in patients with SI and more frequently in patients diagnosed with SI at T3. Higher levels of circulating IL-2, IL-10, IL-6, TNF, INF-γ and CXCL-10 were observed in SI patients along with marked correlations between these mediators and IL-4 and IL-17, showing a plurality in the profile with a mix of Th1/Th2/Th17 response. The present study reports for the first time the synergistic effects of local infection and envenoming on the inflammatory response represented by local manifestations, which reflected on laboratorial parameters and inflammatory mediators and thus help improve the clinical management of SI associated to Bothrops SBE.

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“…IL-6 plays an intrinsic role in the acute-phase wound response, may modulate local and systemic post-injury events by being the most persistent cytokine to mediate post-injury complications; and is robustly correlated with adverse clinical events and outcomes after mechanical trauma, burn injury, and elective surgery [55]. On wounding, elevated levels of IL-6 were detected within 24 h of bacterial infection during the initial inflammatory phase, which gradually diminished by the eighth day [65]. IL-6 was the only pro-inflammatory cytokine, the levels of which were persistently elevated post-burn injury; IL-6 levels in the serum peaked during the first few hours after injury and correlated directly with the area of the burn injury, the magnitude of the trauma, the duration of surgery, and the risk of postoperative complications [66].…”

Section: Bmentioning

confidence: 99%

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review

Vasalou,

Kotidis,

Tatsis

et al. 2023

JCM

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Wound healing is a complex and meticulously orchestrated process involving multiple phases and cellular interactions. This narrative review explores the intricate mechanisms behind wound healing, emphasizing the significance of cellular processes and molecular factors. The phases of wound healing are discussed, focusing on the roles of immune cells, growth factors, and extracellular matrix components. Cellular shape alterations driven by cytoskeletal modulation and the influence of the ‘Formin’ protein family are highlighted for their impact on wound healing processes. This review delves into the use of absorbable meshes in wound repair, discussing their categories and applications in different surgical scenarios. Interleukins (IL-2 and IL-6), CD31, CD34, platelet rich plasma (PRP), and adipose tissue-derived mesenchymal stem cells (ADSCs) are discussed in their respective roles in wound healing. The interactions between these factors and their potential synergies with absorbable meshes are explored, shedding light on how these combinations might enhance the healing process. Recent advances and challenges in the field are also presented, including insights into mesh integration, biocompatibility, infection prevention, and postoperative complications. This review underscores the importance of patient-specific factors and surgical techniques in optimizing mesh placement and healing outcomes. As wound healing remains a dynamic field, this narrative review provides a comprehensive overview of the current understanding and potential avenues for future research and clinical applications.

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Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Cited by 7 publications

References 20 publications

Administration of neem (Azadirachta indica A. Juss) leaf extract decreases TNF- and #945; and IL-6 expressions in dextran sodium sulfate-induced colitis in rats

Administration of neem (Azadirachta indica A. Juss) leaf extract decreases TNF- and #945; and IL-6 expressions in dextran sodium sulfate-induced colitis in rats

Inflammatory Profile Associated with Secondary Infection from Bothrops atrox Snakebites in the Brazilian Amazon

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review

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