Estimation of Arsenic Bioaccessibility in Edible Seaweed by an in Vitro Digestion Method

Jm, Laparra; Vélez, Dinoraz; Montoro, R.; Barberá, Reyes; Farré, R.

doi:10.1021/jf034537i

Cited by 162 publications

(119 citation statements)

References 36 publications

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“…The highest inorganic arsenic concentrations were found in raw rice at 0.074 mg/kg, followed by flour at 0.011 mg/kg, grape juice at 0.009 mg/kg, and cooked spinach at 0.006 mg/kg. Some commercially available seaweeds, especially brown algae varieties, may have high percentages of the total arsenic present as inorganic arsenic (>50 %) (Almela et al, 2002;Laparra et al, 2003). Total arsenic concentrations ranging from 17 to 88 mg/kg dry mass were found in commercially available seaweeds (van Netten et al, 2000).…”

Section: Previously Reported Occurrence Resultsmentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

856

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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Section: Previously Reported Occurrence Resultsmentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

856

220

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“…Recently, the in vitro model has been widely used to study the bioaccessibility and risk assessment of heavy metals, persistent organic pollutants, mycotoxins from soils, toys, food, herbal medicine, cosmetics, etc. [12][13][14][15][16][17]. The Fenghuang mining area in western Hunan province, China, has one of the largest known geochemical concentrations of mercury, lead, and zinc in China.…”

Section: Introductionmentioning

confidence: 99%

Bioaccessibility and Risk Assessment of Cadmium from Uncooked Rice Using an In Vitro Digestion Model

Yang

Zhang

et al. 2011

Biol Trace Elem Res

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Cadmium (Cd)-contaminated rice is one of the most important sources of cadmium exposure in the general population from some Asian countries. This study was conducted to assess cadmium exposure from uncooked rice in rural mining areas based on the bioaccessible fraction of cadmium using an in vitro digestion model. The biotoxic effects of cadmium in uncooked rice from mining areas were much higher than those in the control area, based not only on their higher total concentration (52.49 vs. 7.93 μg kg −1 ), but also on their higher bioaccessibility (16.94% vs. 2.38%). In the mining areas, the bioaccessible fraction of cadmium in uncooked rice has a significant positive correlation with the total concentration of cadmium in rice and there was quarterly unsafe rice to the public in the mining areas. The results indicated that the in vitro digestion model could be a useful and economical tool for providing the solubilization or bioaccessibility of uncooked rice in the mining area. The results could be helpful in conducting future experiments of cooked rice in the vitro model.

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“…Stability of the mackerel hydrolysate peptides against in vitro gastrointestinal digestion was assessed using pepsin and pancreatin according to the method of Laparra et al (2003) Food Technol., 10 (4): 158-166, 2015 boiling for 10 min and this solution acted as sample control. After digestion the mixture was boiling for 10 min to inactivate the pepsin.…”

Section: Stability In Simulated Gastrointestinal Digestionmentioning

confidence: 99%

Stability of Mackerel (Trachurus japonicas) Hydrolysate with Iron-Binding Capacity in Simulated Gastrointestinal Fluids

Zhang¹,

Sun²,

Huang³

2015

American J. of Food Technology

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The aim of this study was to investigate the stability of mackerel (Trachurus japonicas) processing byproducts protein hydrolysate with iron-binding capacity in vitro simulated gastrointestinal systems. The changes in molecular weight distribution and iron-binding capacity were used for evaluating the stability of the hydrolysate in simulated gastrointestinal digestion. The molecular weight of mackerel hydrolysate with iron-binding capacity was mostly less than 1300 Da and composted mainly by tripeptides to undepeptides. The hydrolysate was stable in gastric or intestinal digestion separately for 5 h, or two-stage gastrointestinal digestion. The iron-binding capacity did not change significantly during gastrointestinal digestion. The mackerel processing byproducts hydrolysate had potential in iron fortification functional ingredients of food industry.

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Estimation of Arsenic Bioaccessibility in Edible Seaweed by an in Vitro Digestion Method

Cited by 162 publications

References 36 publications

Scientific Opinion on Arsenic in Food

Scientific Opinion on Arsenic in Food

Bioaccessibility and Risk Assessment of Cadmium from Uncooked Rice Using an In Vitro Digestion Model

Stability of Mackerel (Trachurus japonicas) Hydrolysate with Iron-Binding Capacity in Simulated Gastrointestinal Fluids

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