Estimation of Absidia ramosa infection in the brain and kidneys of cortisone-treated mice by chitin assay

Absidiosis was produced experimentally in rabbits by intravenous inoculation of 1.4 x 10(5) spores of Absidia corymbifera. Infected rabbits exhibited a rise in body temperature, anorexia, dullness, listlessness, diarrhoea, occasional blindness, convulsions and death in some cases. Mortality occurred mainly between 6 to 9 days post infection (DPI) and overall mortality was 50 per cent during the three week observation period. No significant difference was observed in erythrocytic indices viz., Hb, PCV, TEC in control and infected rabbits. However, erythrocyte sedimentation rate was considerably increased in the infected rabbits. A state of leucocytosis was observed in the infected rabbits, which was due to increase in the relative percentage of neutrophils and decrease in lymphocytes. There was a significant increase in blood urea nitrogen concentrations of infected rabbits from 3 to 14 DPI as compared to controls, but serum creatinine values were not significantly altered at any stage of infection. The cause of death was attributed to kidney failure and uraemia in infected rabbits. The rabbit was found to be a suitable model for the study of absidiosis.

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Experimental Absidia corymbifera infection in rabbits: Clinicopathological studies

Sodhi

Khanna

Sadana

et al. 1996

Mycopathologia

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Comparison of the growth of virulent and attenuated strains of Candida albicans in the kidneys of normal and cortisone-treated mice by Chitin assay

et al. 1979

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Candida albicans strain 22114 was avirulent for mice compared with strain 19321 in that, administered intravenously, 10(6) blastospores of 22114 failed to kill whereas 10(6) blastospores of 19321 produced 100% mortality. Cortisone treatment rendered mice susceptible to killing by 22114. Chitin assay showed that cortisone stimulated the growth of both strains in the mouse kidney. Growth of 19321 was increased up to five-fold and 22114 up to forty-fold. The strains may have differential susceptibility to cortisone-sensitive host defences which control fungal growth in vivo.

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Use of biochemical markers to determine growth, development and biomass of fungi in infected tissues, with particular reference to antagonistic and mutualistic biotrophs

Whipps

Haselwandter

McGEE

1982

Transactions of the British Mycological Society

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Estimation of Absidia ramosa infection in the brain and kidneys of cortisone-treated mice by chitin assay

Cited by 5 publications

References 13 publications

Experimental Absidia corymbifera infection in rabbits: Clinicopathological studies

Experimental Absidia corymbifera infection in rabbits: Clinicopathological studies

Comparison of the growth of virulent and attenuated strains of Candida albicans in the kidneys of normal and cortisone-treated mice by Chitin assay

Use of biochemical markers to determine growth, development and biomass of fungi in infected tissues, with particular reference to antagonistic and mutualistic biotrophs

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