Estimation of 6Ckine and Chemokine Receptor Type 7 With Some Biomarkers in Type 2 Diabetes Mellitus Patients

Abstract

Type 2 Diabetes Mellitus (T2DM) it is a complex disease associated with metabolic disorders. The main aim of this study was to accurately estimate the concentration of Chemokine (6Ckine) and Chemokine Receptor Type 7 (CCR7) with some biomarkers in blood serum of T2DM patients and compare it with healthy control. Identical in gender and age ranged from (40-70) years, 60 diabetics and 30 healthy controls participated in this study of 6Ckine and CCR7 serum concentration was estimated by Enzyme Linked Immune Sorbent Assay (ELISA) technique. An 6Ckine and CCR7 were no different between patients and healthy control. Oxidized Low Density Lipoprotein (Ox-LDL) showed increased significantly in T2DM patients compared to healthy control, and insulin shows decrease significantly in T2DM patients compared to healthy control, and each for age and Body Mass Index (BMI) also increase significant between T2DM patients and healthy control. The conclusion of this study showed an increase in the level of Ox-LDL in patients compare with healthy control, no different between patients and healthy control in levels of both 6Ckine and Chemokine Receptor Type 7, decrease in insulin level in patients compare with healthy control.