Estimation of 1999–2004 dietary daily intake of PCDDs, PCDFs and dioxin-like PCBs by a total diet study in metropolitan Tokyo, Japan

Sasamoto, Takeo; Ushio, Fusao; Kikutani, Norihisa; Saitoh, Yasuhide; Yamaki, Yumiko; Hashimoto, Tsuneo; Horii, Shozo; Nakagawa, Junichi; Ibe, Akihiro

doi:10.1016/j.chemosphere.2005.10.057

Cited by 92 publications

(36 citation statements)

References 16 publications

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“…In this study, we confirmed that Chlorella supplementation in pregnant women contributed to a reduction of blood PCDD and PCDF levels. Small amounts of dioxin invade our bodies daily through many kind of food, including fish, shellfish, meat, eggs, milk and dairy products [23]. Dioxins that have accumulated in the body are also secreted with bile into the intestine [24,25].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Nagayama¹,

Maruyama²,

Uchikawa³

et al. 2015

Clinics Mother Child Health

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Adverse health consequences from prenatal, perinatal and postnatal exposure to background levels of dioxins in the environment, including polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), have been reported. In order to prevent or reduce such health risks, it is important to decrease maternal exposure to dioxins. This study investigated the effect of maternal supplementation with Chlorella on dioxin concentration levels in the blood during pregnancy. Twenty healthy pregnant women participated in the study. Ten received 6 g of Chlorella daily from gestational week 16-20 until the day of delivery (Chlorella group); ten others did not (control group). The blood PCDFs and PCDD/DFs concentrations in the Chlorella group significantly decreased during the supplementation period, from 2.20 ± 1.66 to 1.00 ± 0.61 pg-TEQ/g lipid (p<0.05) and from 5.48 ± 4.01 to 3.38 ± 1.96 pg-TEQ/g lipid ( p<0.05), respectively. The levels of dioxins in the control group did not change significantly. These results suggest that Chlorella supplementation may be effective in reducing dioxin exposure in pregnant woman.

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Section: Discussionmentioning

confidence: 99%

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Nagayama¹,

Maruyama²,

Uchikawa³

et al. 2015

Clinics Mother Child Health

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“…Therefore, a dietary intake assessment is often performed as an exposure and risk estimate for the general population regarding this type of contaminants (Bilau et al, 2008;Bocio and Domingo, 2005;Charnley and Doull, 2005;Darnerud et al, 2006;Fattore et al, 2006;Kiviranta et al, 2004;Sasamoto et al, 2006;Taioli et al, 2005;Vrijens et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

Bilau

Henauw

Schroijen

et al. 2009

Environment International

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Dioxin-like activity was measured in the serum of 1425 Flemish men and women via the CALUX assay. The adults, aged between 50 and 65 years, participated in a large biomonitoring program, executed by the Flemish Center of Expertise for Environment and Health between 2002 and 2006. Within the context of this biomonitoring program also dietary intake of dioxin-like contaminants was assessed through a food frequency questionnaire. The relation between the estimated dietary intake and the dioxin-like activity in serum was evaluated using multivariate analyses: a logistic model was performed on the total population, while a linear regression analysis was done on the subsample with quantifiable dioxin activity levels in serum. Region, gender, age, BMI, smoking status, as well as dietary habits were entered in the model, with dioxin level as an outcome estimate. Both the logistic and linear model confirmed the contribution of dietary intake to the dioxin activity measured in serum. Also BMI and region were found to be associated with dioxin activity levels.

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“…There is evidence of long range transport of these substances to regions where they have never been used or produced, resulting in exposure of most human populations to POPs through consumption of fat-containing food such as fish, dairy products, and meat [78][79][80][81][82][83], with the highest POP concentrations being commonly found in fatty fish [75][76][77][78][79][80][81][82][83][84][85][86]. Humans bioaccumulate these lipophilic pollutants in their adipose tissues for many years because POPs are highly resistant to metabolic degradation [78][79][80][81][82][83][84][85][86][87]. Persistent Organic Pollutants are widespread amongst the American public.…”

Section: Persistent Organic Pollutantsmentioning

confidence: 99%

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet

Strombom¹,

Rose²

2017

EMIJ

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Those following a plant-based diet have a 78% reduction risk of Type II diabetes mellitus (T2DM), as well as a 56% reduced risk of metabolic syndrome and a lower average BMI, 22.4 for men and 21.8 for women. Vegetarians have less skeletal intramyocellular lipids, and better myocellular glucose disposal and mitochondrial function, and therefore have less peripheral insulin resistance. Vegetarians and vegans also have a much better inflammatory status, indicated by lower levels of inflammatory markers such as CRP and inflammatory adipocytokines such as IL-6, leptin, and higher levels of anti-inflammatory adipocytokines such as adiponectin. Those following a plant-based diet consume much less persistent organic pollutants (POPs) which have been shown to cause beta-cell mitochondrial dysfunction. Finally, the gut microbiome of vegetarians has been shown to play a role in reducing insulin resistance and the level of inflammation in the body, and consequently their risk of T2DM. Interventional studies show a reduction of HbA1C by as much as 2.4 percentage pts, which is more than is usually achieved with Metformin. Other clinical variables also show improvement such as reductions in BMI, total and LDL cholesterol and hsCRP. Studies show compliance rates are good, ranging from 84% to 99%. Medications should be titrated as the patient shows improvements. Treatment with a plantbased diet has no contraindications or adverse reactions. Keywords:

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Estimation of 1999–2004 dietary daily intake of PCDDs, PCDFs and dioxin-like PCBs by a total diet study in metropolitan Tokyo, Japan

Cited by 92 publications

References 16 publications

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet

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