The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

Bilau, Maaike; Henauw, Stefaan De; Schroijen, Carmen; Bruckers, Liesbeth; Hond, Elly Den; Koppen, Gudrun; Matthys, Christophe; Mieroop, Els Van de; Keune, Hans; Baeyens, Willy; Nelen, Vera; Larebeke, Nicolas Van; Schoeters, Greet

doi:10.1016/j.envint.2008.05.007

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…Similarly, a cross-sectional analysis of children in Germany also found an inverse association between serum PCBs and body weight (Link et al 2005). Typically, higher BMI for adults is associated with higher serum concentrations of these compounds (Bilau et al 2009; Collins et al 2007; Michalek et al 1996). However, in a follow-up analysis of the Seveso cohort, neither BMI nor percent body fat was associated with serum dioxin concentrations after adjustment for sex (Landi et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

Burns

Williams

Sergeyev

et al. 2009

Environ Health Perspect

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BackgroundAlthough sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels.ObjectivesWe investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia.MethodsWe used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia.ResultsThe median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8–35.0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2–20.6).ConclusionsOur findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.

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Section: Discussionmentioning

confidence: 99%

Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

Burns

Williams

Sergeyev

et al. 2009

Environ Health Perspect

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“…At the same time, it has explicitly been shown that if HBM is combined with ambient monitoring and questionnaire data, exposure sources can be identified (e.g. Bilau et al, 2009;Kolossa-Gehring et al, 2012;Cerna et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…of the participants is collected. As this type of information relates to the individual's exposure profile, it is very relevant in the interpretation of an individual's biomarker profile as well (Bilau et al, 2009;Haug et al, 2011;Johansson et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

Smolders

Hond

Koppen

et al. 2015

Environmental Research

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“…The human biomonitoring project investigates the very complex relation between environmental pollution and human health by measuring some selected pollutants and certain health effects in human beings, using biomarkers. (Bilau et al 2009;Schroijen et al 2008) and social scientific research (Keune et al, 2008a).…”

Section: The Centre Of Expertise For Environment and Health (Ceh)mentioning

confidence: 99%

From Theory to Practice: A Path Through Imperfection-Lessons from Policy Oriented Environment and Health Research in Belgium

Keune¹,

Morrens²,

Loots³

et al. 2011

J Multidiscip Eval

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Background: Dealing with complex issues per definition bears the burden of imperfection. Whatever comforting theoretical concepts may promise, real life complexity will take its messy toll once travelling from conceptual ambition to real life practice. We specifically reflect on the social scientific contribution to these inter- and transdisciplinary endeavours. Purpose: We reflect on how social scientific research has tried to find its way in complex real life research practice in the field of environment and health and specifically focus on the challenges posed by the imperfections we encountered. Setting: Two case studies in the field of environment and health in Belgium. One case study focuses on policy interpretation of research results. The other focuses on a selection of research priorities. Intervention: Not applicable. Research Design: Not applicable. Data Collection and Analysis: inter- and transdisciplinary research and multi-criteria analysis Findings: Resulting from our practical experiences we present a typology of imperfections: imperfect information, imperfect expert assessment, imperfect processing of incommensurable data, imperfect socio-political weighing/deliberation and reflection on imperfection. As easy as it seems to design processes of structuring complex issues and decision making in which involvement of a relevant diversity of actors and factors is considered praiseworthy, as complicated it is, as we have shown, in practice to organize and live up to expectations. In judging the quality of this endeavour, diverse theoretical yardsticks maybe applied that will not necessarily do justice to the practical complications of research practice. The concepts of abduction, intersubjectivity and transferability, offer interesting qualitative notions of pragmatic approaches that seem relevant to our work. Keywords: complexity, environment & health, interdisciplinary and transdisciplinary research, social science, imperfection, quality

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The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

Cited by 8 publications

References 33 publications

Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

From Theory to Practice: A Path Through Imperfection-Lessons from Policy Oriented Environment and Health Research in Belgium

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