Estimating peak streamflows in a basin is an essential issue in hydrology, especially for projects and management of hydraulic infrastructures such as dams, spillways, and bridges. In this context, this article presents a regionalization of annual maximum streamflows for the upper and middle Paraopeba River region in Minas Gerais, proposing a regional equation to calculate maximum streamflows using the index-flood technique by the generalized extreme value (GEV) distribution. GEV distribution parameters were estimated using the L-moments method, and the adjustment of the statistical model was performed by applying the Anderson-Darling test. The results of the hydrological regionalization were compared with those obtained by the local frequency analysis, performed for the considered fluviometric stations, observing absolute deviations from 11.91 to 58.78%.